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Sunday
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| 2:00 pm - 9:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Keynote Session: Metal Homeostasis in Development and Disease
Discussion Leader: Roland Lill (Philipps-Universitaet Marburg, Germany)
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| 7:40 pm - 7:50 pm |
Opening Remarks
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| 7:50 pm - 8:30 pm |
Svetlana Lutsenko (Johns Hopkins University, USA)
"The Role of Copper Homeostasis in Lipid Metabolism"
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| 8:30 pm - 8:40 pm |
Discussion
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| 8:40 pm - 9:20 pm |
Ralf Mendel (Braunschweig University of Technology, Germany)
"Molybdenum Metabolism: Pathways, Atomic Structures, Diseases"
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| 9:20 pm - 9:30 pm |
Discussion
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Monday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Metals in Enzyme Function
Discussion Leader: David Giedroc (Indiana University, USA)
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| 9:00 am - 9:25 am |
Nigel Robinson (Durham University, United Kingdom)
"A Cellular Logic for Enzyme Metalation"
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| 9:25 am - 9:35 am |
Discussion
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| 9:35 am - 10:00 am |
Daniel Kosman (State University of New York at Buffalo, USA)
"Multicopper Metallo-Oxidases in Cellular Iron and Copper Metabolism"
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| 10:00 am - 10:10 am |
Discussion
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| 10:10 am - 10:20 am |
Selected from Poster Abstracts: Clorissa Washington-Hughes (University of South Carolina, USA)
"A Direct Correlation Between Enterobactin Transport and Nickel Resistance in E. coli"
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| 10:20 am - 10:25 am |
Discussion
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| 10:25 am - 10:35 am |
Selected from Poster Abstracts: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
"You Are What You Don't Eat: Bacterial Adaptation to Nutritional Immunity"
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| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 11:05 am |
Coffee Break
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| 11:05 am - 11:30 am |
Vishal Gohil (Texas A&M University, USA)
"New Insights into Mitochondrial Copper Delivery to Cytochrome c Oxidase"
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| 11:30 am - 11:40 am |
Discussion
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| 11:40 am - 12:05 pm |
Sabeeha Merchant (University of California, Los Angeles, USA)
"Dynamic Metal Storage in Intracellular Organelles"
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| 12:05 pm - 12:15 pm |
Discussion
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| 12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Kevin Waldron (Newcastle University, United Kingdom)
"Evolutionarily-Driven Cambialism in a Key Metalloenzyme Important During Staphylococcal Infection"
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| 12:25 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Structural Basis of Metalloprotein Function
Discussion Leader: Amy Rosenzweig (Northwestern University, USA)
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| 7:30 pm - 7:55 pm |
Amie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
|
| 7:55 pm - 8:05 pm |
Discussion
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| 8:05 pm - 8:30 pm |
Hans Christensen (Technical University of Denmark, Denmark)
"The Structure of Dopamine β-Hydroxylase: The Cu Enzyme that Converts Dopamine to Norepinephrine"
|
| 8:30 pm - 8:40 pm |
Discussion
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| 8:40 pm - 8:50 pm |
Selected from Poster Abstracts: Oriana Fisher (Northwestern University, USA)
"Characterization of a Unique Copper-Binding Protein from Methanotrophs"
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| 8:50 pm - 8:55 pm |
Discussion
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| 8:55 pm - 9:20 pm |
Richard Ortega (Centre National de la Recherche Scientifique (CNRS), France)
"Imaging Bio-Metals in Neurons with X-Ray Nanobeams"
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| 9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 8:30 am - 9:00 am |
Group Photo
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| 9:00 am - 12:30 pm |
Metal Homeostasis
Discussion Leader: David Eide (University of Wisconsin-Madison, USA)
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| 9:00 am - 9:25 am |
Mitchell Knutson (University of Florida, USA)
"ZIP14 and ZIP8: Novel Players in Manganese Transport and Homeostasis"
|
| 9:25 am - 9:35 am |
Discussion
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| 9:35 am - 10:00 am |
Somshuvra Mukhopadhyay (The University of Texas at Austin, USA)
"Unexpected Hypothyroidism in Mice Lacking the Manganese Efflux Transporter SLC30A10"
|
| 10:00 am - 10:10 am |
Discussion
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| 10:10 am - 10:20 am |
Selected from Poster Abstracts: Tom Bartnikas (Brown University, USA)
"Mechanisms of Mammalian Metal Excretion"
|
| 10:20 am - 10:25 am |
Discussion
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| 10:25 am - 10:35 am |
Selected from Poster Abstracts: Ciro Cubillas (Washington University in St. Louis, USA)
"A Genomic Analysis of Zinc-Regulated Transcription in Caenorhabditis elegans"
|
| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 11:05 am |
Coffee Break
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| 11:05 am - 11:30 am |
Frederic Barras (Aix Marseille University / CNRS, France)
"Antibiotics and Metals: New Facts to an Old Story"
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| 11:30 am - 11:40 am |
Discussion
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| 11:40 am - 12:05 pm |
Ute Kraemer (Ruhr University Bochum, Germany)
"An Integrated Analysis of Metal Hyperaccumulation in Arabidopsis halleri"
|
| 12:05 pm - 12:15 pm |
Discussion
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| 12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Caiyong Chen (Zhejiang University, China)
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
|
| 12:25 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Metal Sensing and Dynamics
Discussion Leader: Daniela Buccella (New York University, USA)
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| 7:30 pm - 7:55 pm |
Ankona Datta (Tata Institute of Fundamental Research, India)
"Balancing Selectivity and Cellular Localization: Toward Optimal Sensors for Tracking Mn(II)"
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| 7:55 pm - 8:00 pm |
Discussion
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| 8:00 pm - 8:25 pm |
Amit Reddi (Georgia Institute of Technology, USA)
"Heme Gazing: Probing Heme Trafficking, Signaling, and Dynamics with Fluorescent Sensors and Affinity Reagents"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:55 pm |
James Imlay (University of Illinois at Urbana-Champaign, USA)
"Molecular Explanations for the Toxicity of Oxygen"
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| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:25 pm |
Patricia Kiley (University of Wisconsin-Madison, USA)
"The Impact of Oxygen on Iron Homeostasis"
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| 9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Metalloprotein Biogenesis and Signaling
Discussion Leader: Frederic Barras (Aix Marseille University / CNRS, France)
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| 9:00 am - 9:25 am |
Amanda Bird (The Ohio State University, USA)
"Metallation of the Pho8 Alkaline Phosphatase in Fission Yeast"
|
| 9:25 am - 9:35 am |
Discussion
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| 9:35 am - 10:00 am |
Simon Labbe (University of Sherbrooke, Canada)
"Spotlight on Schizosaccharomyces pombe Heme Acquisition Proteins"
|
| 10:00 am - 10:10 am |
Discussion
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| 10:10 am - 10:20 am |
Selected from Poster Abstracts: Sven Freibert (Philipps-Universität Marburg, Germany)
"Structural and Functional Insights into Mitochondrial Fe/S Cluster Synthesis"
|
| 10:20 am - 10:25 am |
Discussion
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| 10:25 am - 10:35 am |
Selected from Poster Abstracts: Byung-Eun Kim (University of Maryland, USA)
"The Ctr1 Cu+ Transporter in Cardiovascular Function and Systemic Copper Signaling"
|
| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 11:05 am |
Coffee Break
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| 11:05 am - 11:30 am |
Donita Brady (University of Pennsylvania, USA)
"Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes"
|
| 11:30 am - 11:40 am |
Discussion
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| 11:40 am - 12:05 pm |
Silke Leimkuhler (University of Potsdam, Germany)
"The Connection of Molybdenum Cofactor Biosynthesis to Other Cellular Pathways at a Glance"
|
| 12:05 pm - 12:15 pm |
Discussion
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| 12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Kurt Warnhoff (Massachusetts General Hospital, USA)
"Interkingdom Transfer of Molybdenum Cofactor from E. coli to C. elegans"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Metals in Host-Pathogen Interactions
Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA)
|
| 7:30 pm - 7:55 pm |
Pascal Arnoux (Institute of Biosciences and Biotechnology (BIAM), Aix-Marseille University, France)
"The Old Roots of Nicotianamine: Discovery of Analogs in Pathogenic Bacteria"
|
| 7:55 pm - 8:00 pm |
Discussion
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| 8:00 pm - 8:25 pm |
Christopher McDevitt (The University of Adelaide, Australia)
"The Antimicrobial Role of Zinc at the Host-Pathogen Interface"
|
| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:55 pm |
Dennis Thiele (Duke University School of Medicine, USA)
"How Mammals and Fungal Pathogens Engage in a Tug-of-War over Copper"
|
| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:25 pm |
Alejandro Vila (National University of Rosario, Argentina)
"Metallo-Beta-Lactamases: Periplasmic Raiders of the Lost Zinc"
|
| 9:25 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Metals in Physiology and Disease
Discussion Leader: Valeria Culotta (Johns Hopkins University, USA)
|
| 9:00 am - 9:25 am |
Marla Berry (University of Hawaii at Manoa, USA)
"Selenium and Sex: Competition Between Brain and Testes for Se Results in Male-Specific Consequences in Mice and Men"
|
| 9:25 am - 9:35 am |
Discussion
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| 9:35 am - 10:00 am |
Elizabeth Leibold (University of Utah, USA)
"Iron Deficiency Caused by Loss of Iron-Regulatory Protein 2 Disrupts Mitochondrial Function and Comprises β-Cell Function"
|
| 10:00 am - 10:10 am |
Discussion
|
| 10:10 am - 10:20 am |
Selected from Poster Abstracts: Aslam Khan (University of Missouri, USA)
"A Role for Ceruloplasmin in Innate Immunity"
|
| 10:20 am - 10:25 am |
Discussion
|
| 10:25 am - 10:35 am |
Selected from Poster Abstracts: Sarju Patel (National Institutes of Health, USA)
"A Novel Interaction Between Cytosolic Iron Chaperones PCBP1 and BolA2"
|
| 10:35 am - 10:40 am |
Discussion
|
| 10:40 am - 11:10 am |
Coffee Break
|
| 11:10 am - 11:35 am |
Stefano Rivella (Children's Hospital of Philadelphia, USA)
"The Dark Side of Iron in Erythropoiesis"
|
| 11:35 am - 11:45 am |
Discussion
|
| 11:45 am - 11:55 am |
Selected from Poster Abstracts: Daniel Kornitzer (Technion - Israel Institute of Technology, Israel)
"Structure of a Fungal Heme-Iron Acquisition Pathway"
|
| 11:55 am - 12:00 pm |
Discussion
|
| 12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Sargurunathan Subashchandrabose (Wake Forest School of Medicine, USA)
"Protective Role of Copper During Urinary Tract Infection"
|
| 12:10 pm - 12:15 pm |
Discussion
|
| 12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Daniela Buccella (New York University, USA)
"Targeted Fluorescent Sensors Reveal Sub-Cellular Mg2+ Dynamics in Cell Death"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Keynote Session: Metal Homeostasis from Worms to Mammals
Discussion Leader: Michael Petris (University of Missouri, USA)
|
| 7:30 pm - 8:10 pm |
Vadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA)
"Two Hundred Years of Selenium Research"
|
| 8:10 pm - 8:20 pm |
Discussion
|
| 8:20 pm - 9:00 pm |
Iqbal Hamza (University of Maryland, USA)
"Heme Trafficking: Lessons from Bloodless Worms"
|
| 9:00 pm - 9:10 pm |
Discussion
|
| 9:10 pm - 9:20 pm |
General Discussion
|
| 9:20 pm - 9:30 pm |
Closing Remarks
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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