Metals in Physiology and Disease

July 23 - 28, 2017

Chairs Michael Petris and Roland Lill

Vice Chairs Iqbal Hamza and Amanda Bird

Mount Snow

89 Grand Summit Way

West Dover, VT, US

Venue and Travel Information

Conference Description

The Gordon Research Conference (GRC) series on "Cell Biology of Metals" provides a truly outstanding forum for scientific exchanges, presentations and discussions in the emerging field of metals in biology, focusing on the acquisition, distribution, sensing and utilization of metals in proteins, cells and systems from bacteria to humans. This conference has now become a cornerstone of the field and is unique in attacking broad research questions such as how metal cofactors are assembled to how metal ions play roles in metabolic and infectious diseases. The 2017 Cell Biology of Metals GRC will be held on July 23-28 at Mount Snow Resort in West Dover, VT. The program is organized around the theme of "Mechanisms from Microbes to Humans". Session topics include metals in enzyme function, metalloenzyme structures, metal homeostasis, metal sensing and dynamics, metalloprotein biogenesis and signaling, metals in host-pathogen interactions and metals in physiology and disease. The conference will be comprised of keynote presentations, research and poster talks, poster discussions, and informal scientific discussions. This meeting will bring together an outstanding and diverse cadre of molecular and structural biologists, biochemists, geneticists, cell biologists, physiologists and clinicians to interact and brainstorm on new discoveries, ideas and directions in basic and applied research on the cell biology of metals. Given the increase in the number of metabolic and infectious diseases linked to changes in cellular metal homeostasis, this meeting fills a critical niche for investigating the underlying mechanism(s) of these disorders and for brainstorming approaches for novel diagnostics, prognostics, and therapeutics.

Related Meeting

This GRC will be held in conjunction with the "Cell Biology of Metals (GRS)" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Metal Homeostasis in Development and Disease Discussion Leader: Roland Lill (Philipps-Universitaet Marburg, Germany)
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:30 pm	Svetlana Lutsenko (Johns Hopkins University, USA) "The Role of Copper Homeostasis in Lipid Metabolism"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	Ralf Mendel (Braunschweig University of Technology, Germany) "Molybdenum Metabolism: Pathways, Atomic Structures, Diseases"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metals in Enzyme Function Discussion Leader: David Giedroc (Indiana University, USA)
9:00 am - 9:25 am	Nigel Robinson (Durham University, United Kingdom) "A Cellular Logic for Enzyme Metalation"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Daniel Kosman (State University of New York at Buffalo, USA) "Multicopper Metallo-Oxidases in Cellular Iron and Copper Metabolism"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Selected from Poster Abstracts: Clorissa Washington-Hughes (University of South Carolina, USA) "A Direct Correlation Between Enterobactin Transport and Nickel Resistance in E. coli"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	Selected from Poster Abstracts: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA) "You Are What You Don't Eat: Bacterial Adaptation to Nutritional Immunity"
10:35 am - 10:40 am	Discussion
10:40 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	Vishal Gohil (Texas A&M University, USA) "New Insights into Mitochondrial Copper Delivery to Cytochrome c Oxidase"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Sabeeha Merchant (University of California, Los Angeles, USA) "Dynamic Metal Storage in Intracellular Organelles"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Kevin Waldron (Newcastle University, United Kingdom) "Evolutionarily-Driven Cambialism in a Key Metalloenzyme Important During Staphylococcal Infection"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Structural Basis of Metalloprotein Function Discussion Leader: Amy Rosenzweig (Northwestern University, USA)
7:30 pm - 7:55 pm	Amie Boal (Pennsylvania State University, USA) "Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	Hans Christensen (Technical University of Denmark, Denmark) "The Structure of Dopamine β-Hydroxylase: The Cu Enzyme that Converts Dopamine to Norepinephrine"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	Selected from Poster Abstracts: Oriana Fisher (Northwestern University, USA) "Characterization of a Unique Copper-Binding Protein from Methanotrophs"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	Richard Ortega (Centre National de la Recherche Scientifique (CNRS), France) "Imaging Bio-Metals in Neurons with X-Ray Nanobeams"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Metal Homeostasis Discussion Leader: David Eide (University of Wisconsin-Madison, USA)
9:00 am - 9:25 am	Mitchell Knutson (University of Florida, USA) "ZIP14 and ZIP8: Novel Players in Manganese Transport and Homeostasis"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Somshuvra Mukhopadhyay (The University of Texas at Austin, USA) "Unexpected Hypothyroidism in Mice Lacking the Manganese Efflux Transporter SLC30A10"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Selected from Poster Abstracts: Tom Bartnikas (Brown University, USA) "Mechanisms of Mammalian Metal Excretion"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	Selected from Poster Abstracts: Ciro Cubillas (Washington University in St. Louis, USA) "A Genomic Analysis of Zinc-Regulated Transcription in Caenorhabditis elegans"
10:35 am - 10:40 am	Discussion
10:40 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	Frederic Barras (Aix Marseille University / CNRS, France) "Antibiotics and Metals: New Facts to an Old Story"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Ute Kraemer (Ruhr University Bochum, Germany) "An Integrated Analysis of Metal Hyperaccumulation in Arabidopsis halleri"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Caiyong Chen (Zhejiang University, China) "TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Metal Sensing and Dynamics Discussion Leader: Daniela Buccella (New York University, USA)
7:30 pm - 7:55 pm	Ankona Datta (Tata Institute of Fundamental Research, India) "Balancing Selectivity and Cellular Localization: Toward Optimal Sensors for Tracking Mn(II)"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Amit Reddi (Georgia Institute of Technology, USA) "Heme Gazing: Probing Heme Trafficking, Signaling, and Dynamics with Fluorescent Sensors and Affinity Reagents"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	James Imlay (University of Illinois at Urbana-Champaign, USA) "Molecular Explanations for the Toxicity of Oxygen"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:25 pm	Patricia Kiley (University of Wisconsin-Madison, USA) "The Impact of Oxygen on Iron Homeostasis"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metalloprotein Biogenesis and Signaling Discussion Leader: Frederic Barras (Aix Marseille University / CNRS, France)
9:00 am - 9:25 am	Amanda Bird (The Ohio State University, USA) "Metallation of the Pho8 Alkaline Phosphatase in Fission Yeast"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Simon Labbe (University of Sherbrooke, Canada) "Spotlight on Schizosaccharomyces pombe Heme Acquisition Proteins"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Selected from Poster Abstracts: Sven Freibert (Philipps-Universität Marburg, Germany) "Structural and Functional Insights into Mitochondrial Fe/S Cluster Synthesis"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	Selected from Poster Abstracts: Byung-Eun Kim (University of Maryland, USA) "The Ctr1 Cu+ Transporter in Cardiovascular Function and Systemic Copper Signaling"
10:35 am - 10:40 am	Discussion
10:40 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	Donita Brady (University of Pennsylvania, USA) "Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Silke Leimkuhler (University of Potsdam, Germany) "The Connection of Molybdenum Cofactor Biosynthesis to Other Cellular Pathways at a Glance"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Kurt Warnhoff (Massachusetts General Hospital, USA) "Interkingdom Transfer of Molybdenum Cofactor from E. coli to C. elegans"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Metals in Host-Pathogen Interactions Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA)
7:30 pm - 7:55 pm	Pascal Arnoux (Institute of Biosciences and Biotechnology (BIAM), Aix-Marseille University, France) "The Old Roots of Nicotianamine: Discovery of Analogs in Pathogenic Bacteria"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Christopher McDevitt (The University of Adelaide, Australia) "The Antimicrobial Role of Zinc at the Host-Pathogen Interface"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:55 pm	Dennis Thiele (Duke University School of Medicine, USA) "How Mammals and Fungal Pathogens Engage in a Tug-of-War over Copper"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:25 pm	Alejandro Vila (National University of Rosario, Argentina) "Metallo-Beta-Lactamases: Periplasmic Raiders of the Lost Zinc"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metals in Physiology and Disease Discussion Leader: Valeria Culotta (Johns Hopkins University, USA)
9:00 am - 9:25 am	Marla Berry (University of Hawaii at Manoa, USA) "Selenium and Sex: Competition Between Brain and Testes for Se Results in Male-Specific Consequences in Mice and Men"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Elizabeth Leibold (University of Utah, USA) "Iron Deficiency Caused by Loss of Iron-Regulatory Protein 2 Disrupts Mitochondrial Function and Comprises β-Cell Function"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Selected from Poster Abstracts: Aslam Khan (University of Missouri, USA) "A Role for Ceruloplasmin in Innate Immunity"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	Selected from Poster Abstracts: Sarju Patel (National Institutes of Health, USA) "A Novel Interaction Between Cytosolic Iron Chaperones PCBP1 and BolA2"
10:35 am - 10:40 am	Discussion
10:40 am - 11:10 am	Coffee Break
11:10 am - 11:35 am	Stefano Rivella (Children's Hospital of Philadelphia, USA) "The Dark Side of Iron in Erythropoiesis"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	Selected from Poster Abstracts: Daniel Kornitzer (Technion - Israel Institute of Technology, Israel) "Structure of a Fungal Heme-Iron Acquisition Pathway"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Sargurunathan Subashchandrabose (Wake Forest School of Medicine, USA) "Protective Role of Copper During Urinary Tract Infection"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Daniela Buccella (New York University, USA) "Targeted Fluorescent Sensors Reveal Sub-Cellular Mg2+ Dynamics in Cell Death"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Metal Homeostasis from Worms to Mammals Discussion Leader: Michael Petris (University of Missouri, USA)
7:30 pm - 8:10 pm	Vadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA) "Two Hundred Years of Selenium Research"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 9:00 pm	Iqbal Hamza (University of Maryland, USA) "Heme Trafficking: Lessons from Bloodless Worms"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	General Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure