Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Metals in the Omics Era
Discussion Leader: Vadim Gladyshev (Brigham and Women's Hospital / Harvard Medical School, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
David Eide (University of Wisconsin-Madison, USA)
"Meeting Your Quota: The Cellular Economy of Zinc"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Chu Wang (Peking University, China)
"Mining Metalloproteome by Chemical and Computational Proteomics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Lucia Banci (University of Florence, Italy)
"Structural and Functional Characterization of Processes for Copper Transport and FeS Protein Biogenesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals at the Host-Pathogen Interface
Discussion Leader: Angela Wilks (University of Maryland, USA)
9:00 am - 9:25 am
Anirban Banerjee (National Institutes of Health, USA)
"In Vitro Reconstitution and Mechanistic Dissection of Iron Transport at the Host-Pathogen Interface for Legionella pneumophila "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Amanda Oglesby-Sherrouse (University of Maryland, Baltimore, USA)
"Iron-Regulated Interactions Between Cystic Fibrosis Pathogens"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Duncan Wilson (University of Aberdeen, United Kingdom)
"Feeding on the Host: How Do Human Fungal Pathogens Acquire Essential Trace Metals During Infection?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Paul Sigala (University of Utah School of Medicine, USA)
"Iron Utilization by Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Amy Medlock (University of Georgia, USA) and Caryn Outten (University of South Carolina, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Sensation and Homeostasis
Discussion Leader: Nigel Robinson (Durham University, United Kingdom)
6:00 pm - 6:25 pm
David Giedroc (Indiana University, USA)
"Molecular Mechanisms of Bacterial Metallostasis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Sergi Puig (Instituto de Agroquimica y Tecnologia de Alimentos (IATA-CSIC), Spain)
"Regulatory and Metabolic Responses to Iron Deficiency"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Kerry Kornfeld (Washington University School of Medicine, USA)
"Zinc Sensing and Signaling in C. elegans "
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Systemic Metal Sensing
Discussion Leader: Caroline Philpott (National Institutes of Health, USA)
9:00 am - 9:25 am
Scot Leary (University of Saskatchewan, Canada)
"The Liver Releases a Systemic Signal to Cell Non-Autonomously Suppress the Adaptive Immune System"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jodie Babitt (Massachusetts General Hospital / Harvard Medical School, USA)
"Serum and Tissue Iron Sensing by the Liver"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Byung-Eun Kim (University of Maryland, USA)
"An Unexpected Role for Metal Transporters in Systemic Metabolism"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Samira Lakhal-Littleton (University of Oxford, United Kingdom)
"The Renal Hepcidin/Ferroportin Axis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Partitioning
Discussion Leader: Sabeeha Merchant (University of California, Berkeley, USA)
6:00 pm - 6:25 pm
Adam Hughes (University of Utah, USA)
"Ironing-out the Connection Between Mitochondria and Lysosomes"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Paul Cobine (Auburn University, USA)
"Mitochondrial Copper Transporter Modulates Targets Inside and Outside of Mitochondria"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Amit Reddi (Georgia Institute of Technology, USA)
"Handling Heme: Probing the Mechanisms Underlying Heme Trafficking and Utilization"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metallocofactors
Discussion Leader: Ralf Mendel (Braunschweig University of Technology, Germany)
9:00 am - 9:25 am
Guenter Schwarz (University of Cologne, Germany)
"Molybdenum Cofactor Synthesis and Enzymes in Mitochondria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Gunhild Layer (University of Freiburg, Germany)
"Enzymology of Heme Biosynthesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Martin Warren (University of Kent, United Kingdom)
"The Special Relationship Between Cobalt and the Corrin Ring of Vitamin B12"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Amy Medlock (University of Georgia, USA)
"Unraveling the Complex(ity) of Heme Synthesis and Distribution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Paradigms in Metal Metabolism
Discussion Leader: Valeria Culotta (Johns Hopkins University, USA)
6:00 pm - 6:25 pm
Dennis Thiele (Duke University School of Medicine, USA)
"How Cells Import Copper and Cope with Copper Deficiency"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Peng Chen (Cornell University, USA)
"Understanding Bacterial Metal Defense via Single-Molecule/Cell Microscopy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Amy Palmer (University of Colorado Boulder, USA)
"Zinc Regulation of the Mammalian Cell Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Metals in Physiology and Disease
Discussion Leader: Svetlana Lutsenko (Johns Hopkins University, USA)
9:00 am - 9:25 am
Martina Muckenthaler (Heidelberg University, Germany)
"Out-of-Balance: Pathophysiological Consequences of Iron Overload"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Somshuvra Mukhopadhyay (The University of Texas at Austin, USA)
"Manganese Homeostasis and Induced-Parkinsonism: Insights from Studies of a Rare Genetic Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Herve Puy (Hôpitaux Universitaires Paris Nord Val de Seine, France)
"Lessons from Porphyrias: Disproportion of Iron and Heme"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Stephen Kaler (National Institutes of Health, USA)
"Mechanisms of ATP7A-Related Copper Transport Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Cellular Metal Compartmentalization and Regulation
Discussion Leader: Michael Petris (University of Missouri, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
Mary Lou Guerinot (Dartmouth College, USA)
"Metal Dynamics: From the Soil to the Seed"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:05 pm
Introduction by Discussion Leader
7:05 pm - 7:45 pm
Roland Lill (Philipps-Universität Marburg, Germany)
"Biogenesis of Iron-Sulfur Proteins in Eukaryotes: Mitochondria, Mitosomes, Mechanisms and Maladies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure