Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Perspectives on the Mechanism and Function of Cell Death in Health and Disease
Discussion Leader: Ana Garcia-Saez (University of Cologne, Germany)
7:40 pm - 8:25 pm
Manolis Pasparakis (University of Cologne, Germany)
"Regulation of Necroptosis and its Role in Inflammation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Francis Chan (Liangzhu Laboratory, Zhejiang University, China)
"Black as the Devil and Pure as an Angel: The Cell Death-Independent Functions of RIP Kinases in Physiology"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamental Mechanisms of Cell Death
Discussion Leaders: Lynn Wong (University of Zurich, Switzerland) and Douglas Green (St. Jude Children's Research Hospital, United States)
9:00 am - 9:20 am
Kim Newton (Genentech, United States)
"The Good and The Bad of Caspase Inhibition"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Mathieu Bertrand (Ghent University, Belgium)
"Repression of TNF Cytotoxicity by Unconventional Autophagy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Michelle Kelliher (UMass Chan Medical School, United States)
"Endogenous Z-Nucleic Acids Trigger Zbp1-Mediated Cell Death and Bone Marrow Failure in RIPK1-HEM KO Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Tiffany Reese (University of Texas Southwestern Medical Center, United States)
"Viral Mimicry of a Cell Death Protein to Induce Viral Egress"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"RIPK1 in Health and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Monica Yabal (Technical University of Munich, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innate Immune Sensing and Cell Death
Discussion Leaders: Katia Cosentino (University of Osnabrück, Germany) and Andrew Oberst (University of Washington, United States)
7:30 pm - 7:50 pm
Kate Schroder (The University of Queensland, Australia)
"Die Hard: Cell Explosion by Pyroptosis Escalates Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kate Fitzgerald (Umass Chan Medical School, United States)
"Regulation of Inflammasome-Driven Cell Death Responses"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Veit Hornung (Ludwig-Maximilians-Universität Munich, Germany)
"Inflammatory Consequences of Programmed Cell Death Pathways"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Lytic Forms of Cell Death
Discussion Leader: Henning Walczak (University of Cologne, Germany / University College London, United Kingdom)
9:00 am - 9:20 am
James Murphy (Walter and Eliza Hall Institute of Medical Research, Australia)
"Every Dead Thing - the Necroptotic Dead Enzyme, MLKL, in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Katia Cosentino (University of Osnabrück, Germany)
"Decoding Gasdermin Pore Formation at The Single-Molecule Level"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Domagoj Vucic (Genentech, United States)
"Harnessing Cell Death Pathways for Therapeutic Intervention in Inflammatory Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Monica Yabal (Technical University of Munich, Germany)
"Microbial Regulation of Cell-Death in The Intestinal Tract"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Feng Shao (National Institute of Biological Sciences, Beijing, China)
"Gasdermin-Mediated Pyroptosis: Mechanisms & Therapeutics Potentials"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Cell Death
Discussion Leader: John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
7:30 pm - 7:50 pm
Hamid Kashkar (University of Cologne, Germany)
"Beyond Death - How Deadly Protein Complexes induce Inflammatory Disorder"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Lynn Wong (University of Zurich, Switzerland)
"XIAP: Driving Inflammation or Cell Death?"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kevin Ryan (Cancer Research UK Beatson Institute, United Kingdom)
"Connecting Autophagy and Inflammation to Regulate Programmed Cell Death"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Death Signalling Platforms
Discussion Leaders: Kevin Ryan (Cancer Research UK Beatson Institute, United Kingdom) and Kim Newton (Genentech, United States)
9:00 am - 9:20 am
Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
"Molecular Architecture of Caspase-8 Signalling Complexes - from Assembly to Co-Ordinated Control of Life/Death Decisions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andreas Villunger (Medical University of Innsbruck, Austria)
"The PIDDosome: A Versatile Signaling Platform Controlling Cell Death and Survival"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Henning Walczak (University of Cologne, Germany / University College London, United Kingdom)
"Cell Death and Inflammation in Immunity to Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Heidi McBride (McGill University, Canada)
"A Mitochondria to Lysosome Axis of Pyroptotic Cell Death"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Kodi Ravichandran (Washington University School of Medicine, United States)
"Death in the Neighbourhood and Tissue Responses"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Canonical Forms of Cell Death
Discussion Leaders: Michelle Kelliher (UMass Chan Medical School, United States) and Mathieu Bertrand (Ghent University, Belgium)
7:30 pm - 7:50 pm
Marcus Conrad (Helmholtz Zentrum Munich, Germany)
"Ferroptosis as The Root Cause of Neurodegenerative Disease?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Eric Baehrecke (University of Massachusetts Chan Medical School, United States)
"Microglia are Key Executioners of Neuronal Inflammatory Cell Death in A Mouse Model of Vps13D Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Silvia von Karstedt (University of Cologne, Germany)
"Oncogenic KRAS-Induces Necroptotic Priming of Pancreatic Neoplasia"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cancer and the Immune System
Discussion Leaders: Silvia von Karstedt (University of Cologne, Germany) and Hamid Kashkar (University of Cologne, Germany)
9:00 am - 9:20 am
Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"How Does p53 Instruct Cell Fate – Cell Death or Cell Survival and Cell Cycle Arrest?"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anthony Letai (Dana-Farber Cancer Institute, United States)
"BCL-2 Family Regulation of Cell Fate in Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Gemma Kelly (Walter and Eliza Hall Institute of Medical Research, Australia)
"Informing Therapeutic Strategies for p53 Defective Cancers"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stephen Tait (Cancer Research UK Scotland Institute, United Kingdom)
"Mitochondrial and Anti-Tumour Immunity – A Case of Bacterial Mimicry?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Judy Lieberman (Boston Children's Hospital, Harvard Medical School, United States)
"Blown Apart: Mitochondrial Damage in Pyroptosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jannie Borst (Leiden University Medical Center, The Netherlands)
"Key Elements in The T Cell Response to Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Tissue Homeostasis
Discussion Leaders: James Murphy (Walter and Eliza Hall Institute of Medical Research, Australia) and Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
7:30 pm - 7:50 pm
Andrew Oberst (University of Washington, United States)
"Cell Death-Independent Roles of the "Necroptotic" Pathway"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Theresa Pizarro (Case Western Reserve University School of Medicine, United States)
"Live or Let Die: Translational Insights and Clinical Perspectives of Gasdermin B"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lorenzo Galluzzi (Weill Cornell Medicine, United States)
"Mitochondria at The Hub of Cell Death and Immunity in Irradiated Cancer Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Douglas Green (St. Jude Children's Research Hospital, United States)
"Flatliners: Near (Cell) Death Experiences"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure