SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Sally Kornbluth (Duke University School of Medicine) |
7:40 pm - 8:40 pm | John Diffley (London Research Institute, Clare Hall Laboratories)
"The initiation of DNA Replication: Mechanism, Regulation, and role in Genome stability" |
8:40 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromosome Replication and S phase checkpoints |
| Discussion Leader: Johannes Walter (Harvard Medical School) |
9:00 am - 9:25 am | Anindya Dutta (University of Virginia)
"Genomic studies of mammalian DNA replication" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | David MacAlpine (Duke University School of Medicine)
"The role of local transcription and chromatin structure in establishing DNA Replication origins" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Mary Lilly (NIH)
"The Cdk inhibitor Dacapo regulates the meiotic S phase in Drosophila oogenesis" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Maki Asano (Ohio State University)
"Regulation of Endoreplication in Drosophila" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Anja Bielinsky (University of Minnesota)
"The role of PCNA ubiquitination in lagging strand synthesis" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mitosis I |
| Discussion Leader: Jonathon Pines (The Wellcome Trust / CR UK Gurdon Institute) |
7:30 pm - 7:55 pm | Hui Zou (UT Southwestern)
"Target separase to the chromosome cohesins in vertebrate cells" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Jonathon Pines (The Wellcome Trust / CR UK Gurdon Institute)
"Right protein, right place, right time: regulating mitosis by the APC/C" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Mary Dasso (NIH)
"SUMO control of chromosome segregation" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Kerry Bloom (UNC Chapel Hill)
"Chromatin Mechanics at the Centromere" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Cycle Engines and G1 control |
| Discussion Leader: Anindya Dutta (University of Virginia) |
9:00 am - 9:25 am | Frank Uhlmann (London Research Institute)
"Irreversibility of cell cycle transitions: why the clock never turns back" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Fred Cross (The Rockefeller University)
"Cell cycle control: wheels within wheels" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Steve Haase (Duke University)
"Cycling without cyclins: a transcription network oscillator" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Nick Dyson (Mass General, Harvard)
"Uses, and abuses, of the E2F transcription factor" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Brian Dynlacht (New York University)
"Regulation of the centrosome cycle" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oncogenes and Tumor Suppressors I |
| Discussion Leader: Michael Yaffe (MIT) |
7:30 pm - 7:55 pm | Gerard Evan (UCSF) |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Peter Jackson (Genentech)
"Cilia & Cysts: Linking Cell Polarity and Primary Cilia to Tumor Suppression" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Andrea McClatchey (Mass General, Harvard)
"Regulation of membrane receptor distribution and signaling at the cell cortex" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Hermann Steller (The Rockefeller University)
"Regulation of caspases by the ubiquitin-proteasome system" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Cycle Checkpoints |
| Discussion Leader: Steven Reed (The Scripps Research Institute) |
9:00 am - 9:25 am | Helen Piwinica-Worms (Washington University)
"Mammalian Cell Cycle and Checkpoint Contro" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jean Gautier (Columbia University)
"Sensing and signaling from DNA damage" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Michael Yaffe (MIT)
"A Systems Biology Approach Connects DNA Damage Signaling to Cell Cycle Control and Apoptosis" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Danny Lew (Duke University School of Medicine)
"Control of Cell Polarity in Yeast" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Robert Abraham (Wyeth)
"Replication stress and the response to cancer chemotherapeutic agents" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oncogenes and Tumor Suppressor/Genome Stability |
| Discussion Leader: Angelika Amon (MIT) |
7:30 pm - 7:55 pm | David Pellman (Dana Farber Cancer Institute, Harvard)
"Polyploidy, Aneuploidy and Genome Stability" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Eileen White (Rutgers University)
"Connecting autophagy to suppression of inflammation and cancer" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jing Yang (University of California, San Diego)
"Transcriptional Regulation of Tumor Invasion" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Jacqueline Lees (MIT)
"The dual roles of the retinoblastoma protein in cell cycle arrest and apoptosis" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mitosis II |
| Discussion Leader: Kerry Bloom (UNC, Chapel Hill) |
9:00 am - 9:25 am | Angelika Amon (MIT)
"Consequences of aneuploidy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Todd Stukenberg (University of Virginia)
"Building and repairing kinetochore-microtubule interactions" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Hongtao Yu (UT Southwestern)
"Molecular mechanisms of the spindle checkpoint" |
10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:15 am - 11:40 am | Orna Cohen-Fix (NIH)
"Shaping the nucleus in closed and open mitosis" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Andrea Musacchio (IEO)
"Feedback control of mitosis: theory and practice" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Oncogenes and Tumor Suppressors II |
| Discussion Leader: Orna Cohen-Fix (NIH) |
7:30 pm - 7:55 pm | Tak Mak (Ontario Cancer Institutie)
"Cell Growth under metabolic stress" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Kornelia Polyak (Dana Farber Cancer Institute, Harvard)
"Diversity and evolution of breast tumors" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Eric Weiss (Northwestern)
"Regulation of mRNA decay and translation by a cell fate control system" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Adrian Halme (UC Berkeley)
"Retinoids function to coordinate regenerative growth and development" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Steven Reed (The Scripps Institute)
"Breaking down the Oncogene-Induced DNA Damage Response Barrier: the role of Cks proteins" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |