Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Protein Degradation in Development and Disease
Discussion Leaders: Anwesha Dey (Genentech, United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
Michael Rape (HHMI/UC Berkeley, United States)
"Ubiquitin-Dependent Control of Cell Proliferation and Identity"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Ryan Potts (Amgen, United States)
"Leveraging Proximity Biology for the Next Generation of Therapeutics"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Core Cell Cycle Machinery and Cell Division
Discussion Leaders: Laura Buttitta (University of Michigan, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Min Wu (Yale University, United States)
"Understanding Cell Size Homeostasis and Size Sensing at Single Cell Level"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Sue Biggins (Fred Hutchinson Cancer Center, United States)
"Single Molecule Visualization of Kinetochore Assembly"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Melissa Kemp (Georgia Institute of Technology / Emory University, United States)
"Simple Rules of Intracellular Communication for Simulating Emergent Multicellular Organization"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Anwesha Dey (Genentech, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proliferation and Genome Stability
Discussion Leaders: Laura Attardi (Stanford University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Geert Kops (Hubrecht Institute, The Netherlands)
"Origin and Consequences of Chromosome Segregation Errors"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Andrea Ventura (MSKCC, United States)
"Closing the circle: from gene fusions to ecDNAs"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Gallo (Repare Therapeutics, Canada)
"Preclinical Development of PKMYT1 and ATRT Inhibitor Combinations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Cell Cycle Progression and Quiescence
Discussion Leaders: Stefano Di Talia (Duke University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Laura Buttitta (University of Michigan, United States)
"Getting Into and Out of G0"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Gustavo Leone (Medical College of Wisconsin, United States)
"Cancer Associated Fibroblasts (CAFs) Control Tumor Cell Proliferation in Pancreatic Cancer"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Ryan Rountree (Nurix Therapeutics)
"Discovery for Treatment of MYCN-Driven Pediatric Cancers"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Driving the Cell Cycle
Discussion Leaders: Sabrina Spencer (University of Colorado Boulder, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Jennifer Benanti (University of Massachusetts Chan Medical School, United States)
"Decoding Multisite Phosphorylation by CDKs"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Bruce Clurman (Fred Hutchinson Cancer Center, United States)
"Normal and Neoplastic G1 Progression"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Stefano Di Talia (Duke University, United States)
"Cell Cycle Control and Morphogenesis in Early Drosophila Embryos"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Cyclin-Dependent Kinases
Discussion Leaders: Jennifer Benanti (University of Massachusetts Chan Medical School, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Geoffrey Shapiro (Dana-Farber Cancer Institute)
"Reversal of CDK6-Mediated Resistance to CDK4/6 Inhibitors"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Sabrina Spencer (University of Colorado Boulder, United States)
"Rapid Adaptation of CDK2 Inhibitors is Enabled by Plasticity of the CDK2/4/6-Rb-E2F Axis"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Peter Sicinski (Harvard Medical School, United States)
"CDK4 and CDK6 Kinases: From Basic Science to Cancer Therapy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling Pathways in Development and Cancer
Discussion Leaders: Min Wu (Yale University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Amaia Lujambio (Icahn School of Medicine at Mount Sinai, United States)
"Tumor Intrinsic Signaling Pathways in Immune Escape in Liver Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Julien Sage (Stanford University, United States)
"Targeting Cell Cycle Transitions in Cancer Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anwesha Dey (Genentech, United States)
"Targeting the Hippo Pathway in Cancers"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genome Integrity and Immunity
Discussion Leader: Elham Azizi (Columbia University)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Teresa Davoli (New York University School of Medicine, United States)
"'Are Cancer Cells Addicted to Specific Aneuploidies?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Samuel Bakhoum (Memorial Sloan Kettering Cancer Center, United States)
"Chromosomal Instability as a Driver of Epigenetic Alterations in Cancer"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
System Biology and Genomics
Discussion Leaders: Amaia Lujambio (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Elham Azizi (Columbia University)
"Modeling Cell Fate Dynamics in the Microenvironment"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
M. Madan Babu (St Jude Children's Research Hospital, United States)
"Data Science Approaches to Infer Targetable Mechanisms from Cancer Metastasis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure