Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Protein Degradation in Development and Disease
Discussion Leader: Anwesha Dey (Genentech, United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
Alexander M. Cruickshank Lecture: Michael Rapé (HHMI/UC Berkeley, United States)
"Ubiquitin-Dependent Control of Cell Proliferation and Identity"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Ryan Potts (Amgen, United States)
"Leveraging Proximity Biology for the Next Generation of Therapeutics"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Emanuele (University of North Carolina at Chapel Hill, United States)
"Quantitative Proteomics Reveals a Widespread, PLK1-Regulated G2/M Degradation Program and Integration with PKA Signaling Through AKAP2"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Core Cell Cycle Machinery and Cell Division
Discussion Leader: Laura Buttitta (University of Michigan, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Min Wu (Yale University, United States)
"Understanding Cell Size Homeostasis and Size Sensing at Single Cell Level"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Sue Biggins (Fred Hutchinson Cancer Center, United States)
"A Single Molecule Assay Allows the Visualization of Kinetochore Assembly and Function"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Lilian Kabeche (Yale University, United States)
"Identifying a novel regulator of mitotic Plk1"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Melissa Kemp (Georgia Institute of Technology / Emory University, United States)
"Simple Rules of Intracellular Communication for Simulating Emergent Multicellular Organization"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Yuu Kimata (ShanghaiTech University, China)
"Unveiling a Novel Role of CDK4/6 in Mitosis and Genome Maintenance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Timothy Hoffman (University of Colorado Boulder, United States)
"Multiple Cancer Types Rapidly Escape from Multiple MAPK Inhibitors to Generate Mutagenesis-Prone Subpopulations"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Shicong Xie (Stanford University, United States)
"Cell Size Homeostasis Autonomously Determines G1/S Timing in Mammalian Skin Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Anwesha Dey (Genentech, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proliferation and Genome Stability
Discussion Leader: Laura Attardi (Stanford University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Geert Kops (Hubrecht Institute, The Netherlands)
"Centromeric Chromatin Architecture and its Implications for Chromosome Segregation Fidelity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Andrea Ventura (MSKCC, United States)
"Closing the Circle: from Gene Fusions to ecDNAs"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Jake Friske (St. Jude Children's Research Hospital, United States)
"Elucidating the Role of Amplified Enhancer Elements on Double Minutes in MYC -Amplified Medulloblastoma"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Maria del Carmen Lafita Navarro (UT Southwestern Medical Center, United States)
"Uncovering Novel Molecular Players in Cell Growth and Proliferation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Samuel Bakhoum (Memorial Sloan Kettering Cancer Center, United States)
"Chromosomal Instability as a Driver of Tumor Progression and Cellular Plasticity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Cell Cycle Progression and Quiescence
Discussion Leader: Stefano Di Talia (Duke University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Steven Cappell (NCI, United States)
"Loss of Cdk4/6 Activity in S/G2 Phase Leads to Cell Cycle Reversal"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Laura Buttitta (University of Michigan, United States)
"Getting Into and Out of G0"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Ryan Rountree (Nurix Therapeutics, United States)
"Discovery of Degraders for Treatment of MYCN-Driven Pediatric Cancers"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Orlando Arguello-Miranda (North Carolina State University, United States)
"Deep Learning Characterization of Quiescence and Non-proliferative Cellular States"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Charlotte Meyer-Gerards (Universtity Hospital Cologne, Germany)
"Dissecting the Mechanism of the Mitotic Surveillance Pathway in Mouse Embryonic Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Tony Ly (University of Dundee, United Kingdom)
"Cell Overgrowth During G1 Arrest Triggers an Osmotic Stress Response and Chronic p38 Activation to Promote Cell Cycle Exit"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Patrick Pfaff (University of California, San Francisco, United States)
"Chemical Strategies for Restoring Tumor Suppressor Functions of the Retinoblastoma Protein"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Driving the Cell Cycle
Discussion Leader: Sabrina Spencer (University of Colorado Boulder, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Jennifer Benanti (University of Massachusetts Chan Medical School, United States)
"Decoding Multisite Phosphorylation by CDKs"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Bruce Clurman (Fred Hutchinson Cancer Center, United States)
"Normal and Neoplastic G1 Progression"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Stefano Di Talia (Duke University, United States)
"Cell Cycle Control and Morphogenesis in Early Drosophila Embryos"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Cyclin-Dependent Kinases
Discussion Leader: Jennifer Benanti (University of Massachusetts Chan Medical School, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Geoffrey Shapiro (Dana-Farber Cancer Institute, United States)
"Reversal of CDK6-mediated Resistance to CDK4/6 Inhibitors"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Hanjun Lee (Massachusetts General Hospital, United States)
"RB Regulates Cohesin Distribution to Repress Insulator Activity, Resulting in E2F-Independent Transcriptional Regulation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Sabrina Spencer (University of Colorado Boulder, United States)
"Rapid Adaptation of CDK2 Inhibitors is Enabled by Plasticity of the CDK2/4/6-Rb-E2F Axis"
10:55 am - 11:05 am
Discussion
11:05 am - 11:15 am
Stefan Gaubatz (University of Wuerzburg, Germany)
"Oncogenic YAP Mediates Changes in Chromatin Accessibility and Activity that Drive Expression of the MybMuB (MMB) Cell Cycle Genes and Sensitizes Cells to CHK1 inhibition"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Peter Sicinski (Harvard Medical School, United States)
"CDK4 and CDK6 Kinases: From Basic Science to Cancer Therapy"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Yumi Konagaya (Ida) (Weill Medical College/Cornell University - New York, NY, United States)
"A State of Partial Rb-E2F Activation Safeguards Proliferation Commitment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Hee Won Yang (Columbia University, United States)
"Plasticity of the Rb-E2F Pathway and External Signaling Coordinate CDK4/6-Independent Cell Cycle Entry"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling Pathways in Development and Cancer
Discussion Leader: Min Wu (Yale University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Amaia Lujambio (Icahn School of Medicine at Mount Sinai, United States)
"Tumor Intrinsic Signaling Pathways in Immune Escape in Liver Cancer"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Julien Sage (Stanford University, United States)
"Targeting Cell Cycle Transitions in Cancer Cells"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Anwesha Dey (Genentech, United States)
"Targeting the Hippo Pathway in Cancers."
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
David Gallo (Repare Therapeutics, Canada)
"Preclinical Development of PKMYT1 and ATR Inhibitor Combinations"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genome Integrity and Immunity
Discussion Leader: Elham Azizi (Columbia University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Bob Duronio (University of North Carolina at Chapel Hill, United States)
"Coupling Replication-Dependent Histone Gene Expression to the Cell Cycle During Animal Development"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Laura Attardi (Stanford University, United States)
"P53 Repurposes an Injury Response in Lung Cancer Suppression"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Gina Tomarchio (Sloan Kettering Institute / Weill Cornell Graduate School of Medical Sciences, United States)
"Dissecting the Roles and Targets of Aurora A kinase in Diploid and Tetraploid Mitosis"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Hyunsook Lee (Seoul National University, South Korea)
"Telomere R-Loops Trigger Phase Separation and Induce Alternative Lengthening of Telomeres upon BRCA2 Abrogation"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Dalia Fleifel (University of North Carolina at Chapel Hill, United States)
"Racing Against Time: c-Myc Overproduction Accelerates Origin Licensing in a Short G1 Phase."
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Junjie Chen (The University of Texas MD Anderson Cancer Center, United States)
"Absence of a Cell Cycle Checkpoint to Monitor Completion of DNA Replication: Implications for Genome Stability and Cancer Development"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
System Biology and Genomics
Discussion Leader: Amaia Lujambio (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Elham Azizi (Columbia University, United States)
"Modeling Cell Fate Dynamics in the Microenvironment"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Paul Geeleher (St. Jude Childrens Research Hospital, United States)
"Using Unsupervised Machine Learning to Analyze Neuroblastoma Single Cells RNA Seq Data"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure