2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Early Life Exposure and Disease
Alessandro Venosa (University of Pennsylvania, USA) and Thomas Gonzalez (University of Michigan , USA)
3:45 pm - 3:50 pm
3:50 pm - 4:05 pm
Jorine Voss (University of Texas at Austin, USA) "Exposure of Peripubertal Rats to Mono-(2-Ethylhexyl) Phthalate (MEHP) Leads to a Pro-Inflammatory Environment in the Testis with the Infiltration of Both Macrophages and Neutrophils"
4:05 pm - 4:10 pm
4:10 pm - 4:25 pm
Elizabeth Martin (University of North Carolina at Chapel Hill, USA) "Sexual Epigenetic Dimorphism in the Human Placenta: Implications for Susceptibility to Stressors During the Prenatal Period"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Microbiota and Development / Reproductive Toxicology
Emma Bowers (Curriculum in Toxicology, University of North Carolina at Chapel Hill, USA) and Karilyn Sant (University of Massachusetts Amherst, USA)
7:30 pm - 7:55 pm
Stephanie Shore (Harvard T.H. Chan School of Public Health, USA) "Obesity and Asthma: Microbiome-Metabolome Interactions"
7:55 pm - 8:00 pm
8:00 pm - 8:25 pm
Tamara Tal (U.S. Environmental Protection Agency, USA) "Host-Associated Microbiota and Chemical Induced Developmental Toxicity"
8:25 pm - 8:30 pm
8:30 pm - 8:45 pm
Dana Walsh (Mayo Clinic, USA) "Metformin Protects Against Chemotherapy-Induced Loss of Gut Microbiota Diversity in Ovarian Cancer"
8:45 pm - 8:50 pm
8:50 pm - 9:05 pm
Alisa Suen (U.S. Environmental Protection Agency, USA) "SIX1 Oncoprotein Is Necessary for Abnormal Uterine Basal Cell Development in Neonatally DES Exposed Mice"
9:05 pm - 9:10 pm
9:10 pm - 9:25 pm
Ludwik Gorczyca (Rutgers University, USA) "Role for Efflux Drug Transporters in Placental Cell Syncytialization"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Uncovering Mechanisms Governing Tissue Metabolic Programming / Toxicogenomics / Immunotoxicology
Rosa Chan (University of California, San Francisco, USA), Suzanne Martos (Johns Hopkins University, USA) and John Szilagyi (Rutgers University, USA)
9:00 am - 9:15 am
Katelyn Lavrich (University of North Carolina at Chapel Hill, USA) "Air Pollutant 1,2-Naphthoquinone Inhibits Glycolysis Through Peroxide-Dependent Protein Inactivation in Human Bronchial Epithelial Cells"
9:15 am - 9:20 am
9:20 am - 9:35 am
Anna Pfalzer (Vanderbilt University, USA) "Alterations in Arginine, Cholesterol and Energy Metabolism Are Rescued with Manganese Exposure in a Mouse Model of Huntington's Disease"
9:35 am - 9:40 am
9:40 am - 9:55 am
Kari Neier (University of Michigan School of Public Health, USA) "Altered Early Life Pancreatic Redox Environment as a Potential Mechanism Linking Perinatal Phthalate Exposures with Altered Metabolic Profile in Adulthood"
9:55 am - 10:00 am
10:00 am - 10:15 am
Eva Vitucci (University of North Carolina at Chapel Hill, USA) "A Cellular Game of Telephone: Trans-Tissue Reprogramming of Responses to Toxic Stimuli"
10:15 am - 10:20 am
10:20 am - 10:35 am
Christina Post (University of Rochester Medical Center, USA) "AHR Activation During Development Skews Antiviral CD8+ T Cells Toward Senescence and Exhaustion"
10:35 am - 10:40 am
10:40 am - 10:55 am
Thomas Hammond (University of Basel, Switzerland) "Do Acyl Glucuronide Metabolites of Carboxylic Acid Drugs Have a Potential to Elicit Idiosyncratic Hypersensitivity?"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Data Rigor and Reproducibility: Considerations for Statistical Analysis, Transparency, and Management
Emily Martell (University of Rhode Island, USA)
1:30 pm - 1:40 pm
Shaun McCullough (U.S. Environmental Protection Agency, USA) "Increasing Reproducibility Through Quality Experimental Design and Methodology"
1:40 pm - 1:45 pm
1:45 pm - 2:05 pm
Glenn Begley (BioCurate Pty Ltd, Australia) "The Current Problem with Rigor and Reproducibility"
2:05 pm - 2:15 pm
2:15 pm - 2:25 pm
Radhika Dhingra (U.S. Environmental Protection Agency, USA) "Statistical Analysis 'Good Practices' to Improve Data Rigor"
2:25 pm - 2:30 pm
2:30 pm - 3:00 pm
Fill in GRS Evaluation Forms