Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Centromeres: From Evolution to Human Health
Discussion Leader: Iain Cheeseman (Whitehead Institute, United States)
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7:40 pm - 7:50 pm |
Opening Remarks
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7:50 pm - 8:30 pm |
Harmit Malik (Fred Hutchinson Cancer Research Center, United States)
"Genetic Conflicts Drive Innovation in Centromeric Proteins"
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8:30 pm - 8:40 pm |
Discussion
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8:40 pm - 9:20 pm |
Genevieve Almouzni (Institut Curie / CNRS, France)
"CENP-A and H3 Variants: a Team Involved in Genome Architecture"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Biophysical Properties of Centromeres
Discussion Leader: Stephen Harrison (Harvard Medical School, United States)
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9:00 am - 9:20 am |
Ekaterina Grishchuk (University of Pennsylvania, United States)
"Kinetochore Assembly Mechanisms: Lessons from In Vitro Reconstruction of the Ndc80 Recruitment via CENP-T Pathway"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
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9:40 am - 9:45 am |
Discussion
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9:45 am - 10:05 am |
Ben Black (University of Pennsylvania, United States)
"Innovations to Strengthen Centromeres and Resist Spindle Forces"
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10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 10:55 am |
Short Talk Selected from Poster Abstracts
|
10:55 am - 11:00 am |
Discussion
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11:00 am - 11:20 am |
David Barford (MRC Laboratory of Molecular Biology, United Kingdom)
"Mechanism of Centromere Recognition by Regional and Point Kinetochores from Structures of the Human and Budding Yeast Inner Kinetochore Complexes"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Andrea Musacchio (Max Planck Institute of Molecular Physiology, Germany)
"The Inner Self of the Centromere"
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11:50 am - 12:00 pm |
Discussion
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12:00 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Elaine Dunleavy (National University of Ireland Galway, Ireland) and Rachel O'Neill (University of Connecticut, United States)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Centromeres in Meiosis and Stem Cell Division
Discussion Leader: Arshad Desai (University of California, San Diego, United States)
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7:30 pm - 7:50 pm |
Elaine Dunleavy (National University of Ireland Galway, Ireland)
"Centromere Assembly and Function in Drosophila Germline Stem Cells"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Florian Steiner (University of Geneva, Switzerland)
"Setting Centromere Identity in the C. elegans Germ Line"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Yukiko Yamashita (University of Michigan, United States)
"Satellite DNA, Spermatogenesis and Speciation"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Dean Dawson (Oklahoma Medical Research Foundation, United States)
"Centromere-Pairing Mediates Meiotic Chromosome Segregation in Budding Yeast"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Centromere Dysfunction: Chromosome Segregation Defects and Disease
Discussion Leader: Ben Black (University of Pennsylvania, United States)
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9:00 am - 9:20 am |
Daniele Fachinetti (Institut Curie, France)
"How do Human Centromeres Preserve Their Function and Integrity?"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Hironori Funabiki (The Rockefeller University, United States)
"The Nucleosome Remodeler that Facilitates DNA Methylation at Centromere-Associated Repeats"
|
10:10 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:00 am |
Short Talk Selected from Poster Abstracts
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:30 am |
Beth Sullivan (Duke University, United States)
"Diversity in Centromeric States After Dicentric Chromosome Formation"
|
11:30 am - 11:40 am |
Discussion
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11:40 am - 12:00 pm |
Lilian Kabeche (Yale University, United States)
"The Role of ATR on Centromere Identity"
|
12:00 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Centromere Genomics, Evolution and Variability
Discussion Leader: Rachel O'Neill (University of Connecticut, United States)
|
7:30 pm - 7:50 pm |
Ines Drinnenberg (Institut Curie, France)
"Evolution and Regulation of Holocentromeres"
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7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Karen Miga (University of California, Santa Cruz, United States)
"Genetic and Epigenetic Variation Across Human Centromeres"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Julia Cooper (National Cancer Institute, NIH, United States)
"Mechanisms of Meiotic Centromere Dismantlement and Telomere-Mediated Restoration"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Barbara Mellone (University of Connecticut, United States)
"Investigating the Role of Retroelement-Rich Islands at Drosophila Centromeres"
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9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Epigenetic Regulation of Centromere Identity
Discussion Leader: Patrick Heun (University of Edinburgh, United Kingdom)
|
9:00 am - 9:20 am |
Daniel Foltz (Northwestern University, United States)
"Pathways Regulating Human Centromere Deposition"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Fangpu Han (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China)
"The Aspect of Genetics and Epigenetics in Plant Centromeres"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Short Talk Selected from Poster Abstracts
|
10:25 am - 10:35 am |
Discussion
|
10:35 am - 11:10 am |
Coffee Break
|
11:10 am - 11:20 am |
Short Talk Selected from Poster Abstracts
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Yael Nechemia-Arbely (University of Pittsburgh, UPMC Hillman Cancer Center, United States)
"Human Centromeres Drift Through Cellular Proliferation"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Luca Comai (University of California, Davis, United States)
"Epigenetic Mechanisms of CENH3-Based Genome Elimination"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Transcripts and Transcription Control of Centromere Function
Discussion Leader: Claire Francastel (University of Paris Diderot, CNRS, France)
|
7:30 pm - 7:50 pm |
Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
"Heterochromatin Functions"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Michael Blower (Massachusetts General Hospital, United States)
"Regulation of Centromere Transcription by the Cohesion Complex"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Dawn Carone (Swarthmore College, United States)
"Structural Consequences of Pericentric Satellite Expression"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Rachel O'Neill (University of Connecticut, United States)
"Using T2T-Level Comparative Genomics to Study Centromere Function and Evolution"
|
9:20 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Building Blocks Around and Above the Centromere
Discussion Leader: Ann Ehrenhofer-Murray (Humboldt University Berlin, Germany)
|
9:00 am - 9:20 am |
Tatsuo Fukagawa (Osaka University, Japan)
"Assembly of CCAN to Establish a Functional Kinetochore in Vertebrate Cells"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Short Talk Selected from Poster Abstracts
|
9:40 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Jennifer Deluca (Colorado State University, United States)
"Phospho-Regulation of Kinetochore-Microtubule Attachment Stability Through Kinase-Substrate Specificity"
|
10:10 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:00 am |
Short Talk Selected from Poster Abstracts
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:30 am |
Needhi Bhalla (University of California, Santa Cruz, United States)
"The Spindle Contributes to Spindle Checkpoint Strength in C. Elegans"
|
11:30 am - 11:40 am |
Discussion
|
11:40 am - 11:50 am |
Short Talk Selected from Poster Abstracts
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
William Earnshaw (University of Edinburgh, United Kingdom)
"Mapping the Chromatin Folding at a Vertebrate Centromere"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
New Concepts of Centromere Function and Regulation
Discussion Leader: Lars Jansen (University of Oxford, United Kingdom)
|
7:30 pm - 7:50 pm |
Binyam Mogessie (Yale University, United States)
"Emerging Mechanisms of Accurate Chromosome Segregation in Female Meiosis"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Late-Breaking Topic
|
8:10 pm - 8:20 pm |
Discussion
|
8:20 pm - 8:40 pm |
Takashi Akera (National Institutes of Health, United States)
"Centromere De-Condensation as a Reproductive Isolating Barrier in Mouse"
|
8:40 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:10 pm |
Aaron Straight (Stanford University School of Medicine, United States)
"Spatial Organization of Centromeric Chromatin"
|
9:10 pm - 9:20 pm |
Discussion
|
9:20 pm - 9:30 pm |
Closing Remarks
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|