Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structural Approaches to the Study of Tetrapyrroles
This session is devoted to the application of new structural approaches (such as serial femtosecond X-ray crystallography and cryo-EM) to the study of tetrpyrrole systems.
Discussion Leader: Syun-Ru Yeh (Albert Einstein College of Medicine, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Wyatt Yue (University of Oxford, United Kingdom)
"Structure-Guided Drug Design for Aminolevulinate Synthase"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Allen Orville (Diamond Light Source, United Kingdom)
"Time-Resolved Serial Crystallography: Methods and Applications at Synchrotrons and XFELs"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hitomi Sawai (Graduate School of Life Science, University of Hyogo, Japan)
"Structural Basis for Multifunctionality of Heme-Responsive Sensor Proteins in Hemolytic Bacteria"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Trafficking, Signalling and Regulation by Heme
This session will focus on how tetrapyrroles, principally heme, are trafficked, can signal and play regulatory roles in eukaryotic cells.
Discussion Leader: Ann English (Concordia University, Canada)
9:00 am - 9:25 am
Emily Weinert (The Pennsylvania State University, USA)
"Globin Coupled Sensors in Bacterial O2 and NO Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Hiroaki Kitagishi (Doshisha University, Japan)
"Selective Depletion of Endogenous CO In Vitro and In Vivo by Hemoprotein Biomimetic Model Complexes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Andrew Hudson (University of Leicester, United Kingdom)
"Quantitative Maps of Heme in Live Cells Revealed by Fluorescence Lifetime Imaging"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Dennis Stuehr (Cleveland Clinic, USA)
"GAPDH-Dependent Heme Trafficking and Its Regulation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Amy Medlock (University of Georgia, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biogenesis and Functions of Bilins
Bilins are linear tetrapyrroles derived from the oxygenolytic turnover of heme found in most kingdoms of life. This session will focus on their biogenesis and diverse functions from light sensing, signaling to ROS mitigation.
Discussion Leader: J. Clark Lagarias (University of California, Davis, USA)
7:30 pm - 7:55 pm
Beronda Montgomery (Michigan State University, USA)
"Stressing the Role of Tetrapyrrole Homeostasis: TSPO, ROS and Cellular Fitness in Cyanobacteria"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Tammi Richardson (University of South Carolina, USA)
"Phycobiliproteins of Cryptophyte Microalgae"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
William Lanzilotta (University of Georgia, USA)
"Deconstructing Heme: Toxic Tetrapyrroles in a Pathogen's Quest for Iron"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tetrapyrroles in Human Health and Disease
The session will explore the structure and reactivity of different tetrapyrrole systems, with an emphasis on mechanism.
Discussion Leader: Peter Meissner (University of Cape Town, South Africa)
9:00 am - 9:25 am
Makiko Yasuda (Icahn School of Medicine at Mount Sinai, USA)
"Generation and Characterization of a Hepatocyte-Specific Tamoxifen-Inducible Alas1 Knockout Mouse"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Barden Chan (Agios Pharmaceuticals, USA)
"Aminolevulinic Acid Synthase 2 (ALAS2) Inhibition to Treat Erythroporphyrias"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Levi Wood (Georgia Institute of Technology, USA)
"Heme and Hemoglobin Down-Regulate Neuroinflammation and Glial Clearance of Amyloid Beta"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Diane Ward (University of Utah, USA)
"The Role of Abcb10 in Mitochondrial Homeostasis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biology of Tetrapyrroles: Catalysis and Mechanism
Discussion Leader: Elizabeth Boon (Stony Brook University, USA)
7:30 pm - 7:55 pm
Elisa Tomat (University of Arizona, USA)
"Coordination Chemistry of Heme Metabolites: Redox-Active Ligands and Luminescent Radicals"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Brian Crane (Cornell University, USA)
"Bacterial Heme Proteins Involved in Sensing and Regulation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Micah Nelp (Princeton University, USA)
"Redox Regulation of the Immune Response Through Indoleamine 2,3-Dioxygenase 1"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
B12: Biosynthesis, Transport, Pharmacology and Mechanistic Enzymology
This session will cover the recent discoveries of how B12 is assembled and then its involvement in important biomedical and biochemical processes. This includes its collaboration with radical SAM in a wide class of enzymatic reactions, its ability to transport RNA into cells in some cases by RNA-dependent processes, and its pharmacology.
Discussion Leader: Stephen Ragsdale (University of Michigan Medical School, USA)
9:00 am - 9:25 am
Dorota Gryko (Institute of Organic Chemistry, Polish Academy of Sciences, Poland)
"Vitamin B12 Conjugates for Biomedical Applications"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alison Smith (University of Cambridge, United Kingdom)
"B12 Metabolism and the Epigenome"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Ritimukta Sarangi (Stanford Synchrotron Radiation Lightsource, USA)
"X-Ray Spectroscopy and Theoretical Investigations of the B12 Cofactor"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Tessa Young (Durham University, United Kingdom)
"Acquisition of Cobalt for Vitamin B12"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulation and Biosynthesis of Chlorophyll Pigments
This session is aimed at highlighting new details about how the primary chlorophyll pigments of photosynthesis are synthesized and understanding the regulation of photosynthetic gene expression.
Discussion Leader: Jennifer Bridwell-Rabb (University of Michigan, USA)
7:30 pm - 7:55 pm
Min Chen (University of Sydney, Australia)
"Red-Shifted Chlorophylls and Their Biochemical and Biophysical Properties"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jean Alric (CNRS / CEA Cadarache, France)
"An Interaction Between Photosynthetic Electron Transport, Chlororespiration and Chlorophyll Biosynthesis in Chlamydomonas "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Christopher Hunter (University of Sheffield, United Kingdom)
"The Structure and Membrane Organisation of Photosynthetic Complexes"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbial Tetrapyrrole Metabolism
This session will focus on microbial mechanisms of tetrapyrrole synthesis, uptake, utilisation, and degradation.
Discussion Leader: Mark Shepherd (University of Kent, United Kingdom)
9:00 am - 9:25 am
Celia Goulding (University of California, Irvine, USA)
"New Insights into Heme Degradation by IsdG-Type Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Stefan Hofbauer (University of Natural Resources and Life Sciences, Vienna, Austria)
"Biochemistry of Enzymes Involved in the Coproporphyrin-Dependent Heme Biosynthesis Pathway of Gram-Positive Bacteria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Juliette Lecomte (Johns Hopkins University, USA)
"Taming the Heme: The Chemistry of Microbial Hemoglobins"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Michael Niederweis (University of Alabama at Birmingham, USA)
"Heme and Hemoglobin Utilization by Mycobacterium tuberculosis "
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Tetrapyrrole Regulation and Homeostasis
Discussion Leader: Samuel Beale (Brown University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Angela Wilks (University of Maryland, USA)
"Biliverdin: The Green Light for Heme Utilization and Virulence in Pseudomonas aeruginosa "
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Mark O'Brian (University at Buffalo, USA)
"Heme: A Pigment on the Bacterial Palette and the Vegan Palate"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure