Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Trafficking of Tetrapyrroles
Discussion Leader: Amit Reddi (Georgia Institute of Technology, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Kirsten Wolthers (University of British Columbia, Canada)
"Heme Trafficking and Degradation in an Anaerobic Oral Opportunistic Pathogen"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Romila Mascarenhas ( Assistant Professor, University of Oregon , United States)
"Vitamin B12 Trafficking"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Schara Safarian (Max-Planck-Institute of Biophysics / Fraunhofer ITMP, Germany)
"Dissecting the Conformational Complexity and Mechanism of a Bacterial Heme Transporter"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis and Metabolism of Tetrapyrroles
Discussion Leader: Stefan Hofbauer (University of Natural Resources and Life Sciences, Vienna, Austria)
9:00 am - 9:25 am
Jonathan Lindsey (NC State University, United States)
"Synthesis of Native Photosynthetic Tetrapyrroles"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Peng Wang (The University of Hong Kong, Hong Kong SAR China)
"Decoding Plants' Greenness: Posttranslational Control of Chlorophyll Homeostasis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Richiro Ushimaru (The University of Tokyo, Japan)
"Unusual Tetrapyrrole Metabolism in Cyanobacteria"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Andrea Galmozzi (University of Wisconsin Madison School of Medicine and Public Health, United States)
"Heme Synthesis and Metabolic Homeostasis in Brown Adipose Tissue"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Angela Wilks (University of Maryland, United States) and Breann Brown (Vanderbilt University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tetrapyrroles and Disease
Discussion Leader: Makiko Yasuda (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 7:55 pm
Mark Fleming (Boston Children's Hospital, United States)
"Erythroid Glycine Transport and its Role in the Pathogenesis and Treatment of Heme Biosynthesis Disorders"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Luciana Hannibal (Medical Center, University of Freiburg, Germany)
"Pathogenesis of Defective Cobalamin Processing"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Oleh Khalimonchuk (University of Nebraska-Lincoln, United States)
"Mitochondrial Membrane Architecture as a Regulator of Heme Biosynthesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tetrapyrroles in the Environment, Energy Production, and Light Harvesting
Discussion Leader: Nicole Frankenberg-Dinkel (University Kaiserslautern-Landau, Germany)
9:00 am - 9:25 am
Maria Agustina Dominguez Martin (University of Cordoba, Spain)
"Structural Insights into the Cyanobacterial Light-Harvesting Antenna"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Fengbin Wang (University of Alabama Birmingham, United States)
"Cryo-EM of Extracellular Cytochrome Nanowires"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Christopher Gisriel (Yale University, United States)
"Photosynthesis in the Far-Red"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Andrew Hitchcock (University of Sheffield, United Kingdom)
"Tetrapyrrole Biosynthesis in Purple Bacteria: New Players and Old Friends"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tetrapyrroles in Signaling
Discussion Leader: Emily Weinert (Pennsylvania State University, United States)
7:30 pm - 7:55 pm
Kristine Arnvig (University College London, United Kingdom)
"An Unexpected Role for Vitamin B12 in Mycobacterium tuberculosis Pathogenesis and Persistence"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Bindu Paul (Johns Hopkins School of Medicine, United States)
"Non-canonical, Neuroprotective Roles of Biliverdin Reductase A, the Terminal Enzyme in Heme Catabolism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Emma Raven (University of Bristol, United Kingdom)
"The Ever-Changing Landscape of Heme Biology – From Catalysis to Regulation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tetrapyrroles in Medicine
Discussion Leader: Bruce Wang (University of California San Francisco, United States)
9:00 am - 9:25 am
Terry Hinds (University of Kentucky College of Medicine, United States)
"A Drug Discovery Story and New Developments in Personalized Medicine Technology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Mark Shepherd (University of Kent, United Kingdom)
"Steroids as Novel Antimicrobial Drugs that Block Quinol:Haem Interactions"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Brantley Hall (University of Maryland, United States)
"BilR is a Gut Microbial Enzyme that Reduces Bilirubin to Urobilinogen"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Francesca Vinchi (New York Blood Center, United States)
"Physiological and Pathological Implications of Heme-Mediated Activation of Macrophages"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tetrapyrroles in Chemistry and Catalysis
Discussion Leader: Jennifer DuBois (Montana State University, United States)
7:30 pm - 7:55 pm
Mathias Senge (Trinity College Dublin, The University of Dublin, Ireland)
"From Shape to Function – Conformational Engineering of Porphyrins"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jennifer Bridwell-Rabb (University of Michigan, United States)
"A Rieske Catalytic Journey in Chlorophyll Biosynthesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Fengtian Xue (University of Maryland Baltimore, United States)
"Therapeutic Targeting Pseudomonas Aeruginosa Heme Sensing and Utilization Systems"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tetrapyrrole Proteins Structure and Assembly
Discussion Leader: Gunhild Layer (University of Freiburg, Germany)
9:00 am - 9:25 am
Markos Koutmos (University of Michigan, United States)
"Snapshots of a Complex Choreography: B12 -Dependent Methionine Synthase's Catalytic Transformations"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Molly Sutherland (University of Delaware, United States)
"Insights into Heme Binding from the Bacterial Cytochrome c Biogenesis Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Dipti Nayak (University of California, Berkeley, United States)
"Structural and Functional Insights into the Installation of Factor F430 in Methyl-Coenzyme M Reductase"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Oscar Millet (CIC bioGUNE, Spain)
"Biophysical and Biomedical Analysis of the Metabolite Accumulation in the Heme Group Biosynthetic Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Lessons in Tetrapyrrole Metabolism
Discussion Leader: Martin Warren (Quadram Institute Bioscience, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Harry Dailey (Department of Microbiology, Departrment of Biochemistry & Molecular Biology, United States)
"Assembling the Pieces of a Complex Pathway Takes Time"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Bernhard Grimm (Humboldt-Universität Berlin, Germany)
"Multiple Regulatory Factors for the Synthesis of 5-Aminolevulinic Acid"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure