Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Directed Cell Migration
Discussion Leader: Daniel Legler (University of Konstanz, Switzerland)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
Michael Sixt (Institute of Science and Technology Austria, Austria)
"Receptor Desensitisation in Sensing and Generation of Chemotactic Gradients"
9:00 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokine Cues in Innate Immunity
Discussion Leader: Philip Murphy (National Institute of Allergy and Infectious Diseases, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gerry Graham (University of Glasgow, United Kingdom)
"Chemokine Receptors in Inflammation: Redundant or Specific?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Short Talk Selected from Poster Abstracts
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Géraldine Schlecht (University Paris-Saclay, France)
"The CXCL12-CXCR4 Axis in Skin Immunity"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Claudia Jakubzick (Dartmouth School of Medicine, United States)
"Monocyte Derived DCs and Chemokine-Expressing Interstitial Macrophages in the Lung"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Douglas Dyer (University of Manchester, United Kingdom)
"Rethinking the Role of Extracellular Matrix Proteoglycans in Chemokine Function Using CXCL4 (PF4)"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Marco Colonna (Washington University School of Medicine in St. Louis, United States)
"Innate Circuitries Controlling Intestinal Mucosal Immunity"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ACKRs in Health and Disease
Discussion Leader: Ralf Stumm (Jena University Hospita, lFriedrich Schiller University Jena, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Marcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
"The Atypical Chemokine Receptor GPR182"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Stefan Offermanns (Max Planck Institute for Heart and Lung Research, Germany)
"Properties and Biological Functions of the Atypical Chemokine Receptor GPR182"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Johan Duchene (Ludwig Maximilian University of Munich, Germany)
"From DARC Past to Bright ACKR1 Future: A Journey in Transgenic Mouse Models"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chemokines and GPCRs in the Nervous System
Discussion Leader: Marco Colonna (Washington University School of Medicine in St. Louis, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Ralf Stumm (Jena University Hospita, lFriedrich Schiller University Jena, Germany)
"CXCR4-Mediated Regulation of Migration and Maturation of Cortical Interneurons"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Eva Neuhaus (University Hospital Jena, Germany)
"CXCR4 Regulates Injury-Induced Neurogenesis in the Olfactory Epithelium"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Susan Wray (National Institute of Neurological Disorders and Stroke, United States)
"Chemokine Regulation of Cytoskeleton Dynamics in Migrating Neurons"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Saul Villeda (University of California San Francisco, United States)
"Blood to Brain Communication in Cognitive Aging and Rejuvenation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Yuqin Yin (Boston Children's Hospital, Harvard Medical School, United States)
"Chemokines as Potent Stimulators of Optic Nerve Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure, in Silico Modeling and Therapeutic Targeting of Chemokines and Receptors
Discussion Leader: Amnon Peled (Hadassah University Hospital, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Tracy Handel (University of California San Diego, United States)
"The Origin of B-Arrestin Bias in ACKR3"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Brian Volkman (Medical College of Wisconsin, United States)
"Molecular Pharmacology of the Growing Universe of Chemokine Receptor Ligands"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Matthew Albert (Octant Biosciences, United States)
"Bridging Genetic Insights and GPCR-Based Drug Discovery"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemokines in Tumorigenesis and Cancer Immunotherapy
Discussion Leader: Amanda Lund (New York University Grossman School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Thorsten Mempel (Massachusetts General Hospital, United States)
"Discovering Immune Niches of the Tumor Microenvironment Based on Chemokines"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Tristan Courau (University of California San Francisco , United States)
"Immunological Deficiencies of Mouse Models for Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Adit Ben-Baruch (Tel Aviv University, Israel)
"The Expanding World of CXCL8 Regulators in Breast Cancer Progression"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Amnon Peled (Hadassah University Hospital, Israel)
"Controlling CXCR4-Mediated Trafficking of Stem Cells and Leukocytes: Therapeutic Applications in Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Antal Rot (Queen Mary University of London, United Kingdom)
"Erythroid-ACKR1 Changes Cancer: Implications for Patients of African Ancestry"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemokine Functions in Stromal and Lymphatic Barriers
Discussion Leader: Antal Rot (Queen Mary University of London, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Amanda Lund (New York University Grossman School of Medicine, United States)
"Immune Crosstalk Regulates Lymphatic Barriers"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Cornelia Halin Winter (Swiss Federal Institute of Technology, Zurich, Switzerland)
"Regulation of Lymphatic CCL21 Gradients"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Deborah Fowell (Cornell University, United States)
"Transcriptional Reprogramming of Integrins and Chemokine Receptors as T Cells Transition from Transendothelial to Interstitial Migration in Inflamed Tissues"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chemokines in Lymphocyte Differentiation Into Effector and Memory Subsets
Discussion Leader: Deborah Fowell (Cornell University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Susan Schwab (Karya Capital, United States)
"Far From Home: T Cell Migration Through Non-Lymphoid Organs"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Andrew Luster (Massachusetts General Hospital, United States)
"Chemokines and Resident Memory Effector and Regulatory T cells"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Wolfgang Kastenmüller (University of Würzburg, Institute of Systems Immunology, Germany)
"T Cell Dynamics in Lymph Node Microdomains Scaling CD8 T Effector Cell Formation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
"Leveraging T Cell Location for Enhanced Immune Protection"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Chemokine Cues in Lymphoid Organs
Discussion Leader: Susan Schwab (Karya Capital, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Jason Cyster (University of California San Francisco, United States)
"Deciphering the Guidance Cue Code for B Cell Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michael Gerner (University of Washington, United States)
"Illuminating the Microenvironments That Shape the Immune Response"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Hai Qi (Tsinghua University, China)
"Understanding Germinal Center Territoriality"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure