Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Chemokines and Their Receptors in Cancer
3:15 pm - 3:30 pm
Introduction by Discussion Leader
3:30 pm - 3:40 pm
"A Conserved Landscape of Chemokine Receptor Co-Expression Defines the Functional States of CD8+ T Cells in Melanoma"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Defining the Cellular and Molecular Networks that Underlie the Formation and Maturation of Murine Tumour Tertiary Lymphoid Structures"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Chemokine Network in Acute and Chronic Inflammation
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 5:55 pm
"Understanding the Role of Receptor Activator of NF-κB (RANKL) in Inducing Arthritic Response and Its Regulation"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Type 2 Conventional Dendritic Cells Tune Regulatory T Cell Control of Allergic Immunity"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Immature Neutrophils Exhibit CXCR2-Independent Cardiac Infiltration Following Myocardial Infarction"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Beyond the Diseased Organ: Endothelial Cells as Gatekeepers in Systemic Inflammatory Disease"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Naturally Occurring Anti-Chemokine IgM Modulates Chemokine Activity and Gradient Formation"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Discovery of an Evolutionarily Distinct Evasin with Dual CC and CXC Chemokine Inhibitory Activity"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Tissue Constraints Shape CD8+ T Cell Surveillance Modes"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemotactic Agents in Infectious Diseases
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"Signal 4 and Spatial Coordination: Integrating TNFRSF Costimulation and Chemokine-Mediated Positioning in CD8? T Cell Fate"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Intravital Imaging Reveals Dynamic Cytotoxic T Cell–Pericyte Interactions During Extravasation into the Infected Skin"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Characterization of Naturally Occurring Variants of US28"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Chemokine Proteoforms Exhibit Differential Susceptibility to Evasin-3 Inhibitory Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Stabilized Dimeric Variants of CXCL9(74–103) Improve Inflammation Control in Murine Models"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"RaPID Selection of Cyclic Peptides Targeting Chemokine Receptors"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"CCR5 Is Required for Host Defense During Maternal Zika Virus Infection in Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Targeting the Chemokine Network and Drug Development
1:30 pm - 1:45 pm
Introduction by Discussion Leader
1:45 pm - 1:55 pm
"Overcoming Chemokine Network Complexity with Multi-Chemokine Inhibitors"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Loss-of-Adhesion CRISPR Screen Identifies GRK6 as a Potential Therapeutic Target in Multiple Myeloma"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"Improving the In Vivo Pharmacology of the Anti-Inflammatory Peptide CXCL9(74–103) by Fusion to Human Serum Albumin"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes