Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Chromatin Structure: The Nucleosome and Beyond
Discussion Leader: Song Tan (Pennsylvania State University, USA)
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7:40 pm - 8:00 pm |
Geeta Narlikar (University of California, San Francisco, USA)
"Mechanistic Analysis of Heterochromatin Assembly"
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8:00 pm - 8:05 pm |
Discussion
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8:05 pm - 8:25 pm |
Peter Becker (Ludwig Maximilian University of Munich, Germany)
"Genome-Wide In Vitro Reconstitution of Phased Nucleosome Arrays: Cooperation of Boundaries and Remodeling Factors"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:40 pm |
Beat Fierz (École Polytechnique Fédérale de Lausanne, Switzerland)
"Dynamic Transcription Factor Access to Compact Chromatin Revealed by Single-Molecule Fluorescence"
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8:40 pm - 8:45 pm |
Discussion
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8:45 pm - 9:05 pm |
Ana Pombo (Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Germany)
"Genome Architecture Mapping"
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9:05 pm - 9:10 pm |
Discussion
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9:10 pm - 9:20 pm |
Ann Ehrenhofer-Murray (Humboldt University of Berlin, Germany)
"Regulation of Centromere Function in Saccharomyces cerevisiae by the ATAD2 Homolog Yta7"
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9:20 pm - 9:25 pm |
Discussion
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9:25 pm - 9:30 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Chromatin in Focus: Visualizing Chromatin Interactions
Discussion Leader: Carl Wu (Johns Hopkins University, USA)
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9:00 am - 9:20 am |
Xiaowei Zhuang (Harvard University / Howard Hughes Medical Institute, USA)
"Spatial Organization of Chromatin Domains"
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9:20 am - 9:25 am |
Discussion
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9:25 am - 9:45 am |
Wendy Bickmore (MRC Human Genetics Unit, University of Edinburgh, United Kingdom)
"Manipulating and Visualising Chromatin Folding"
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9:45 am - 9:50 am |
Discussion
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9:50 am - 10:10 am |
Bing Ren (University of California, San Diego, USA)
"Regulation of Chromatin Organization at Enhancers"
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10:10 am - 10:15 am |
Discussion
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10:15 am - 10:25 am |
Jorge Beira (ETH Zurich, Switzerland)
"Epigenetic Plasticity: Integrating Signaling Inputs with Chromatin Regulators to Direct Tissue Regeneration or Tumorigenesis"
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10:25 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Carolyn Larabell (University of California, San Francisco, USA)
"Quantifying Heterochromatin in Cells Using Tomography"
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11:20 am - 11:25 am |
Discussion
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11:25 am - 11:45 am |
Hiroshi Kimura (Tokyo Institute of Technology, Japan)
"Chromatin Modification Dynamics in Living Cells"
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11:45 am - 11:50 am |
Discussion
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11:50 am - 12:00 pm |
Vu Nguyen (Johns Hopkins University, USA)
"Single Molecule Imaging of Chromatin Association by the Transcription Initiation Machinery in Living Cells"
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12:00 pm - 12:05 pm |
Discussion
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12:05 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Cigall Kadoch (Dana-Farber Cancer Institute, USA) and Anne Ferguson-Smith (University of Cambridge, United Kingdom)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Chromatin Assembly in Replication and Repair
Discussion Leader: Peter Verrijzer (Erasmus University Medical Center, The Netherlands)
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7:30 pm - 7:50 pm |
Gaelle Legube (University of Toulouse, France)
"Chromatin and Chromosome Dynamics at DNA Double Strand Breaks"
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7:50 pm - 7:55 pm |
Discussion
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7:55 pm - 8:05 pm |
Zhiguo Zhang (Columbia University, USA)
"Histone Segregation at Replicating DNA Strands"
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8:05 pm - 8:10 pm |
Discussion
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8:10 pm - 8:30 pm |
Danesh Moazed (Harvard Medical School, USA)
"Role of Autoregulation in Heterochromatin Propagation"
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8:30 pm - 8:35 pm |
Discussion
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8:35 pm - 8:55 pm |
Lars Jansen (Gulbenkian Institute for Science, Portugal)
"Centromeric Chromatin Assembly and Transmission Across the Cell Cycle"
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8:55 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Philipp Oberdoerffer (National Cancer Institute, NIH, USA)
"Genome Maintenance by a Macro-Histone"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Joanna Achinger-Kawecka (Garvan Institute of Medical Research, Australia)
"Chromosome Conformation Reveals the Regulatory Role of Three-Dimensional Epigenome Remodelling in Endocrine Resistant Breast Cancer"
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9:25 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Chromatin Encounter with Molecular Motors
Discussion Leader: Geeta Narlikar (University of California, San Francisco, USA)
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9:00 am - 9:20 am |
Frank Pugh (Pennsylvania State University, USA)
"Genomic Mechanisms of Gene Regulation and Chromatin Organization"
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9:20 am - 9:25 am |
Discussion
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9:25 am - 9:45 am |
Bradley Cairns (University of Utah, USA)
"Mechanistic Regulation of SWI/SNF-Family Chromatin Remodeling Complexes"
|
9:45 am - 9:50 am |
Discussion
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9:50 am - 10:10 am |
Carlos Bustamante (University of California, Berkeley, USA)
"High-Resolution and High-Accuracy Topographic Map of Nucleosomal Barrier Crossing by Pol II"
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10:10 am - 10:15 am |
Discussion
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10:15 am - 10:25 am |
Sebastian Deindl (Uppsala University, Sweden)
"A Novel Mechanism for Nucleosome Remodeling"
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10:25 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Iestyn Whitehouse (Memorial Sloan-Kettering Cancer Center, USA)
"Coordination of Gene Transcription and DNA Replication"
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11:20 am - 11:25 am |
Discussion
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11:25 am - 11:45 am |
Cigall Kadoch (Dana-Farber Cancer Institute, USA)
"Probing the Structure and Function of Mammalian SWI/SNF Complexes in Human Cancer"
|
11:45 am - 11:50 am |
Discussion
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11:50 am - 12:00 pm |
Blaine Bartholomew (University of Texas MD Anderson Cancer Center, USA)
"Actin-Related Proteins Bind Distinct Nucleosomal Regions to Regulate Nucleosome Spacing by INO80"
|
12:00 pm - 12:05 pm |
Discussion
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12:05 pm - 12:25 pm |
Zhucheng Chen (Tsinghua University, China)
"Structural Insights into the Mechanism of Chromatin Remodelling"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Linking Epigenetics with Metabolism
Discussion Leader: David Tremethick (The Australian National University, Australia)
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7:30 pm - 7:50 pm |
Paolo Sassone-Corsi (University of California, Irvine, USA)
"The Epigenetic and Metabolic Language of the Circadian Clock"
|
7:50 pm - 7:55 pm |
Discussion
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7:55 pm - 8:15 pm |
Jerry Workman (Stowers Institute for Medical Research, USA)
"Histone Modification in Response to Metabolism"
|
8:15 pm - 8:20 pm |
Discussion
|
8:20 pm - 8:30 pm |
Narsis Attar (University of California, Los Angeles, USA)
"The Nucleosome as a Regulator of Copper Metabolism"
|
8:30 pm - 8:35 pm |
Discussion
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8:35 pm - 8:55 pm |
Jane Mellor (University of Oxford, United Kingdom)
"Deconstructing the Relationship Between Chromatin and Transcription Using Mathematical Modelling"
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8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Bilal Sheikh (Max Planck Institute for Immunobiology and Epigenetics, Germany)
"MOF Maintains the Neural Metabolic Milieu Required for Establishment of the Blood Brain Barrier"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Yamini Dalal (National Cancer Institute, NIH, USA)
"Using Predictive Algorithms to Disrupt Cancer Specific Chromatin Interactions"
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9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Reprogramming Chromatin
Discussion Leader: Ana Pombo (Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Germany)
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9:00 am - 9:20 am |
Kenneth Zaret (Perelman School of Medicine, University of Pennsylvania, USA)
"Overcoming Chromatin Barriers to Change Cell Fate"
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9:20 am - 9:25 am |
Discussion
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9:25 am - 9:35 am |
Richard Festenstein (Imperial College London, United Kingdom)
"HP1 Is Crucial for Sex Differences in Gene Expression and Cellular Proliferation"
|
9:35 am - 9:40 am |
Discussion
|
9:40 am - 10:00 am |
Yi Zhang (Harvard Medical School, USA)
"Identifying and Overcoming Epigenetic Barriers that Impede Somatic Cell Nuclear Transfer Cloning"
|
10:00 am - 10:05 am |
Discussion
|
10:05 am - 10:15 am |
Sarah Swygert (Fred Hutchinson Cancer Research Center, USA)
"Condensin-Dependent Chromatin Condensation Represses Transcription Globally During Quiescence"
|
10:15 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Robert Kingston (Massachusetts General Hospital, USA)
"Possible Roles for Compaction and Phase Separation in Repression and Memory"
|
11:10 am - 11:15 am |
Discussion
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11:15 am - 11:25 am |
Patrick Varga-Weisz (Babraham Institute, United Kingdom)
"Genome Organization Analysis Identifies Hallmarks of Ageing in Developing B Cells"
|
11:25 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Thomas Fazzio (University of Massachusetts Medical School, USA)
"Profiling of Pluripotency Factors in Individual Stem Cells and Early Embryos"
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Axel Imhof (Ludwig Maximilian University of Munich, Germany)
"Super Resolution Microscopy and Proximity Based Biotinylation Reveals an Intricate Proteome Composition of Pericentromeric and Centromeric Chromatin"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Frederic Berger (Gregor Mendel Institute, Austria)
"H3K27me3 Reprograming by Dynamics of H3 Variants Licenses Sperm Differentiation and Primes Early Plant Development"
|
12:20 pm - 12:25 pm |
Discussion
|
12:25 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Non-Coding RNA in Chromatin Biology
Discussion Leader: Asifa Akhtar (Max Planck Institute of Immunobiology and Epigenetics, Germany)
|
7:30 pm - 7:50 pm |
L. Stirling Churchman (Harvard Medical School, USA)
"Regulation of Gene Expression"
|
7:50 pm - 7:55 pm |
Discussion
|
7:55 pm - 8:15 pm |
Joost Gribnau (Erasmus MC, The Netherlands)
"X-Inactivation"
|
8:15 pm - 8:20 pm |
Discussion
|
8:20 pm - 8:30 pm |
He Fang (University of Washington, USA)
"Trans- and Cis-Effects of Firre on the Physiology and Structure of the Inactive X Chromosome"
|
8:30 pm - 8:35 pm |
Discussion
|
8:35 pm - 8:55 pm |
Anne Ferguson-Smith (University of Cambridge, United Kingdom)
"Variable Silencing of the Repeat Genome: Implications for Non-Genetic Inheritance"
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Bassem Al-Sady (University of California, San Francisco, USA)
"A Memory Element Imposes Epigenetic Behavior on Intrinsically Labile RNAi-Induced Heterochromatin Spread"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Nick Gilbert (MRC Human Genetics Unit, United Kingdom)
"Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure"
|
9:25 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Histone Modifications and Disease
Discussion Leader: Paolo Sassone-Corsi (University of California, Irvine, USA)
|
9:00 am - 9:20 am |
Ali Shilatifard (Northwestern University, USA)
"Principles of Epigenetics and Chromatin in Development and Human Disease"
|
9:20 am - 9:25 am |
Discussion
|
9:25 am - 9:35 am |
Sharon Dent (University of Texas MD Anderson Cancer Center, USA)
"Functions of Gcn5 and USP22 in Development and Disease"
|
9:35 am - 9:40 am |
Discussion
|
9:40 am - 9:50 am |
Jacques Cote (Laval University Cancer Research Center, Canada)
" Recurrent Oncogenic Chromosomal Translocations Involving the NuA4/TIP60 and PRC2 Complexes Lead to Aberrant Chromatin Landscape"
|
9:50 am - 9:55 am |
Discussion
|
9:55 am - 10:15 am |
Thomas Jenuwein (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Genistein-Induced Stress Signaling Selectively Derepresses Major Satellite Repeat Transcription in Mouse Heterochromatin"
|
10:15 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Yang Shi (Children's Hospital Boston / Harvard Medical School, USA)
"Histone Modifications and Diseases"
|
11:10 am - 11:15 am |
Discussion
|
11:15 am - 11:25 am |
Katerina Gurova (Roswell Park Cancer Institute, USA)
"Consequences of 'Chromatin Damage' in Mammalian Cells"
|
11:25 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Erica Korb (The Rockefeller University, USA)
"Chromatin Function in Neurons and in Neurodevelopmental Disorders"
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 12:00 pm |
Danny Reinberg (Howard Hughes Medical Institute / New York University School of Medicine, USA)
"One Genome, Multiple Phenotypes"
|
12:00 pm - 12:05 pm |
Discussion
|
12:05 pm - 12:25 pm |
Peter Verrijzer (Erasmus University Medical Center, The Netherlands)
"Chromatin Regulation and Tumor Suppression"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 5:30 pm |
Poster Session
|
5:30 pm - 7:30 pm |
Engineering Chromatin
Discussion Leader: L. Stirling Churchman (Harvard Medical School, USA)
|
5:30 pm - 5:50 pm |
Steven Henikoff (Fred Hutchinson Cancer Research Center, USA)
"Asymmetrically Unwrapped Nucleosomes Are Structural Attributes of Active Chromatin"
|
5:50 pm - 5:55 pm |
Discussion
|
5:55 pm - 6:15 pm |
Jef Boeke (NYU Langone Health, USA)
"Reprogramming the Genome"
|
6:15 pm - 6:20 pm |
Discussion
|
6:20 pm - 6:40 pm |
Tom Muir (Princeton University, USA)
"Designer Chromatin"
|
6:40 pm - 6:45 pm |
Discussion
|
6:45 pm - 6:55 pm |
Song Tan (Pennsylvania State University, USA)
"Structural Basis for Activation of SAGA Histone Acetyltransferase Gcn5 by Partner Subunit Ada"
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
David Tremethick (The Australian National University, Australia)
"Redefining Promoter Nucleosomal Architecture in the Context of Cellular Plasticity and Cancer"
|
7:20 pm - 7:25 pm |
Discussion
|
7:25 pm - 7:30 pm |
Closing Remarks
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|