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Chromosome Dynamics

Gordon Research Conference

Chromosome Biology From Cellular, Molecular and Physical Perspectives

June 25 - 30, 2023

Chair

Vice Chair

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Chromosome Dynamics GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Deciphering the regulation and functional consequences of chromosome dynamics is essential for our understanding of cellular function, organism survival and development of disease. Having evolved from the study of inherited traits in pea plants, the field of chromosome biology now encompasses a large number of model systems in all three domains of life and exploits approaches ranging from cell-, molecular- and structural biology to biophysics and computational modelling. The conference aims to bring together scientists from all areas of chromosome research to share new results and ideas. By gathering an international and diverse group of researchers, the conference will promote collaborations, accelerate young scientists’ career advancement and direct future development of the field.

Related Meeting

This GRC will be held in conjunction with the "Chromosome Dynamics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Chromosomes: From Molecules to Cells and Organisms Discussion Leader:
7:40 pm - 7:45 pm	General Discussion
7:45 pm - 8:10 pm	"Chromatin and Chromosomal domains: The Antagonism of Eu- and Hetero-Chromatin"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	Alexander M. Cruickshank Lecture: "Mechanisms of Chromatin Remodeling Machines: Different or the Same?"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Using Exogenous Chromosomes to Explore how Sequence Composition Drives Chromatin Assembly, Activity and 3D Folding"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chromosome Organization and Gene Regulation Discussion Leader:
9:00 am - 9:20 am	"Reconciling Different Views of Enhancer-Promoter Interaction: Seeing is Believing?"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Euchromatin Hopping; Active Enhancers Drive Accessibility, Histone Modifications, RNA- Polymerase Recruitment, and Transcription at Distal Chromatin Through a Chromatin loop Mechanism"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"The role of Genome Architecture in Shaping Brain Architecture"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Micronucleus chromatin state Influences Lamina Structure and Stability Through Nuclear Growth"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"The Histone Chaperone ANP32B Regulates Chromatin Incorporation of the Atypical Human Histone Variant MacroH2A"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Cryo-EM Studies of Chromatin Structure and Dynamics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Sub-Nanometer Resolution Structural Features of Chromatin-Related Complexes in Chromosomes"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Probing Sub-kilobase Chromatin Fiber Folding and Its Regulation by Linker Histones"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Repurposing of CENP-A Chromatin for Neuronal Activation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Polycomb Repressive Complex I Composition and Nucleosomal Scaffold Properties Determine Extend of Chromatin Condensation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Chromosome Replication Discussion Leader:
6:00 pm - 6:20 pm	"Fast DNA Polymerase Target Search Stabilizes the Bacterial Replisome"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"DNSN-1 Recruits GINS for CMG Helicase Assembly During DNA Replication Initiation in Caenorhabditis Elegans"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"The Initiation of Eukaryotic DNA Replication: Mechanism, Regulation and Misregulation"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"The in vivo Measurement of Replication Fork Velocity and Pausing by lag-time Analysis"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Mechanism of de novo Chromatin Assembly During DNA Replication"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Chromosome Instability and Repair Discussion Leader:
9:00 am - 9:20 am	"Mechanisms for the Maintenance of Genome Stability"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Activation of the RpoS Stress Response & Replication Restart After Transcriptional Conflicts in E. coli"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Chromatin Motions in Response to DNA Damage"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Inhibiting the Evolution of Drug Resistance"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"The Karyotypic Landscape of Clonal Populations"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Parental Histone Distribution and Location of the Replication Obstacle at Nascent Strands Control Homologous Recombination"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Single Molecule Studies of Genetic Recombination"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Meiotic Chromosomes Discussion Leader:
6:00 pm - 6:20 pm	"Chromosome Dynamics and the Control of Meiotic Pairing and Synapsis"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Homolog Biorientation in Meiosis I Requires Non-Canonical Functions of Spindle Checkpoint proteins"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Control of male Meiosis by DREAM Complex"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"RNA in Pairing Centers in C. Elegans Meiosis"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"HEIP1 is Required for Efficient Meiotic Crossover Implementation and is Conserved from Plants to Humans"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Disassembling and Reassembling the Synaptonemal Complex in Vivo"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Genome Organization Discussion Leader:
9:00 am - 9:20 am	"Organization of a Multipartite Bacterial Genome"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Chromatin Compaction: A Matter of Life and Death"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Mechanisms of Genome Scaling During Embryogenesis and Evolution"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Non-Canonical Insights from in Situ Cryo-ET Studies of Yeast Chromatin"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Mechanisms of Cohesin-STAG1 and Cohesin-STAG2 Specificity"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Cohesin is not a Symmetric, but a Sequentially Unidirectional DNA loop Extruder"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Genome control by cohesin"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Molecular Mechanism of SMC-Mediated Domain Formation in Archaea"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Multiple Scale Polymer Model of Bacterial Chromosome Organisation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Centromere Structure and Function Discussion Leader:
6:00 pm - 6:20 pm	"Epigenetic Regulation, Heterochromatin and Antifungal Resistance"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Centromere-Enriched Histone Chaperone FACT Associates Directly with the Inner Kinetochore"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Insights into the role of PLK1 in the Epigenetic Maintenance of Centromeres"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Defining a core Configuration for Human Centromeres During Mitosis"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Introns drive Asymmetric Chromosome Inheritance in Ageing"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Mechanical Disengagement of the Cohesin Ring"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Chromosomes, DNA and Supercoiling Discussion Leader:
9:00 am - 9:20 am	"Topological Mechanisms Mediating Intra and Inter-Chromosomal Interactions"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Transcriptional Units form the Elementary Constraining Building Blocks of the Bacterial Chromosome"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"MukBEF Ensures Proper Chromosome Segregation of Highly Transcribed Regions"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"The Regulation of Transcription by Topoisomerases, Supercoiling and MYC"
10:50 am - 11:00 am	Discussion
11:00 am - 11:10 am	"Revealing Mechanism of Smc5/6-Mediated DNA loop Extrusion"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Cryo-EM Structures of Smc5/6 Provide Insights into its Assembly and Functional Mechanisms"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Genome Stability: Interplay Between Double Strand Break (DSB), Chromatin Mobility and SMC Complexes"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Single-Molecule Studies of Chromatin Replication"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Cohesin Dynamics Controls Epansion of DNA Loop by SMC Complexes"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Structural Maintenance of Chromosomes Discussion Leader:
6:00 pm - 6:20 pm	"A Tale of Two Condensins: Molecular Dissection of Mitotic Genome Folding Machines"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"M18BP1 is a Condensin II Loading Factor"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"DNA Topology Sensing in SMC-Based Immunity Systems in Bacteria"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"A Single Molecule Approach to Understanding Sister Chromatid Cohesion Establishment"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Regulation of Cohesin-Mediated Loop Extrusion by CTCF"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13CA284570-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official polices of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Chromosome Dynamics (GRS)

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