Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Chromosomes: From Molecules to Cells and Organisms
Discussion Leader: John Marko (Northwestern University, United States)
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 8:10 pm
Susan Gasser (ISREC Foundation, Switzerland)
"Chromatin and Chromosomal domains: The Antagonism of Eu- and Hetero-Chromatin"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Geeta Narlikar (University of California, San Francisco, United States)
"Mechanisms of Chromatin Remodeling Machines: Different or the Same?"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Romain Koszul (Institut Pasteur / CNRS, France)
"Using Exogenous Chromosomes to Explore how Sequence Composition Drives Chromatin Assembly, Activity and 3D Folding"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromosome Organization and Gene Regulation
Discussion Leader: Katsuhiko Shirahige (Institute for Quantitative Biosciences, The University of Tokyo)
9:00 am - 9:20 am
Wendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"Reconciling Different Views of Enhancer-Promoter Interaction: Seeing is Believing?"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Barbara Meyer (Howard Hughes Medical Institute / University of California, Berkeley, United States)
"X-Chromosome Dosage Compensation: A Single-Molecule Perspective"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Hitoshi Kurumizaka (Institute for Quantitative Biosciences, The University of Tokyo, Japan)
"Cryo-EM Studies of Chromatin Structure and Dynamics"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Coral Zhou (University of California, Berkeley, United States) and Susan Gasser (ISREC Foundation, Switzerland)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromosome Replication
Discussion Leader: Susan Lovett (Brandeis University, United States)
6:00 pm - 6:20 pm
Rodrigo Reyes Lamothe (McGill University, Canada)
"Fast DNA Polymerase Target Search Stabilizes the Bacterial Replisome"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
John Diffley (The Francis Crick Institute, United Kingdom)
"The Initiation of Eukaryotic DNA Replication: Mechanism, Regulation and Misregulation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
James Berger (Johns Hopkins University School of Medicine, United States)
"Mechanisms of Replicative Helicase Loading and Translocation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosome Instability and Repair
Discussion Leader: Julia Cooper (University of Colorado Anschutz Medical Campus, United States)
9:00 am - 9:20 am
Karlene Cimprich (Stanford University School of Medicine, United States)
"Mechanisms for the Maintenance of Genome Stability"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Houra Merrikh (Vanderbilt University, United States)
"Inhibiting the evolution of drug resistance"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gaelle Legube (CBI, CNRS, University of Toulouse, France)
"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eric Greene (Columbia University, United States)
"Single Molecule Studies of Genetic Recombination"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Meiotic Chromosomes
Discussion Leader: Abby Dernburg (University of California, Berkeley, United States)
6:00 pm - 6:20 pm
Jennifer Fung (University of California, San Francisco, United States)
"Chromosome Dynamics and the Control of Meiotic Pairing and Synapsis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Franz K. Klein (Max F. Perutz Laboratories, University of Vienna, Austria)
"Disassembling and Reassembling the Synaptonemal Complex in Vivo"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Organization
Discussion Leader: Steve Bell (Indiana University, United States)
9:00 am - 9:20 am
Xindan Wang (Indiana University, United States)
"Organization of a Multipartite Bacterial Genome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ana Losada (F.S.P. CNIO, Spain)
"Mechanisms of Cohesin-STAG1 and Cohesin-STAG2 Specificity"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Benjamin Rowland (The Netherlands Cancer Institute, The Netherlands)
"Chromosome Organization by Cohesin and Condensin"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Centromere Structure and Function
Discussion Leader: Aaron Straight (Stanford University School of Medicine, United States)
6:00 pm - 6:20 pm
Robin Allshire (Wellcome Centre for Cell Biology, University of Edinburgh, United Kingdom)
"Epigenetic Regulation, Heterochromatin and Antifungal Resistance"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jennifer Gerton (Stowers Institute for Medical Research, United States)
"Defining a core Configuration for Human Centromeres During Mitosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chromosomes, DNA and Supercoiling
Discussion Leader: Adele Marston (University of Edinburgh, United Kingdom)
9:00 am - 9:20 am
Marco Foiani (IFOM ETS, Italy)
"Topological Mechanisms Mediating Intra and Inter-Chromosomal Interactions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Laura Baranello (Karolinska Institutet, Sweden)
"The Regulation of Transcription by Topoisomerases, Supercoiling and MYC"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Nynke Dekker (TU Delft, The Netherlands)
"Single-Molecule Studies of Chromatin Replication"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural Maintenance of Chromosomes
Discussion Leader: Frank Uhlmann (The Francis Crick Institute, United Kingdom)
6:00 pm - 6:20 pm
Tatsuya Hirano (RIKEN, Japan)
"A Tale of Two Condensins: Molecular Dissection of Mitotic Genome Folding Machines"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Stephan Gruber (University of Lausanne, Switzerland)
"DNA Topology Sensing in SMC-Based Immunity Systems in Bacteria"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Jan-Michael Peters (Research Institute of Molecular Pathology (IMP), Austria)
"Regulation of Cohesin-Mediated Loop Extrusion by CTCF"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure