Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Structure, Replication and Maintenance of Chromosomes
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Structural and Biophysical Mechanisms of DNA Replication"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Live Without Loop Extrusion"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Replication and Repair
9:00 am - 9:20 am
"Single-Molecule, Genome-Wide Characterization of Human Replication Kinetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"SspA is a Dynamic Transcription Factor in the E. coli DNA Damage and Cellular Stress Responses"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"DNA Replication and DNA Damage Checkpoint Control"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Bacterial XerCD Recombinase and its Mechanistic Spatiotemporal Regulation During Chromosome Dimer Resolution Examined by Integrated Structural Biology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanisms of Smc5/6-Based Genome Management"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Microhomology-Mediated Template Switching Requires Extensive Pairing of Adjacent Homeologous Regions"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"3’ Heterologous Flaps Influence the Dynamics and Kinetics of Rad51-Mediated D-Loops"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Replisome Passage Through the Cohesin Ring"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosome Structure and Gene Expression
7:30 pm - 7:50 pm
"Structural Roles of Histones and Histone Variants in Prokaryotic Chromatin Organisation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"The Roles of Cohesin and Transcription on Genome Organization in Yeast"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Regulation of X-Chromosome Gene Expression by DNA Loop Extrusion and Phase Separation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"R-loop Formation by CANVAS A2G3 Repeat Stalls RNA Polymerization in vitro"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"A Blueprint of Balance: How a Unique Condensin Complex Assembles on X, Remodels Local Chromatin Architecture, and Represses Expression"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Epigenome Maintenance in Response to DNA Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Rap1-Mediated Steric Hindrance Prevents DNA End Sensing by MRX to Protect Telomeres"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"How to Build and Control a Meiotic DNA-Breaking Machine"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Identification of Mutants with Improved Heat Tolerance of Meiosis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"PARP1 Regulates the Genomic Ribonucleotide Processing Activity of TOP1 to Prevent the Formation of Toxic TOP1-DNA Adducts"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"The Eukaryotic Homology Search Complex Can be Regulated by Donor DNA Tension"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dynamic CTCF-XPC Interplay Coordinates Genome-Wide Nucleotide Excision Repair"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Separase Is Essential for the Mdm2-Dependent Branch of the Mitotic Surveillance Pathway"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Regulation of Meiotic Chromosome Segregation in Mouse Oocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Nucleoid-Binding Protein RicO Associates Replication Origins with the Cell Membrane in Staphylococcus aureus"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Mitotic Eviction of the Histone H3.3 Chaperone Complex HIRA: Why and How"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"A Spatial Reaction-Diffusion Model of Mitotic Signaling Identifies a Network Architecture to Coregulate Mitotic Events"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Dancing Spindles and Tissue Mechanics: How Does Force Regulate Cell Division Orientation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromatin and Epigenetics
9:00 am - 9:20 am
"Exploring the Dynamics of Resistant Epimutant Gain and Loss"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanistic Insights into Chromatin Compartmentalization in Sulfolobus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Targeting LncRNA with Small Molecules to Investigate Chromosome Instability in Cancer"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"ATP-Dependent Remodeling of Chromatin Condensates Uncovers Distinct Mesoscale Effects of Two Remodelers"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dances with Condensates: Establishment of Heterochromatin Compartments and Interplay with Other Nuclear Condensates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"RNA Polymerase II is Not Responsible for the Rarity of Canonical Nucleosomes Inside Yeast Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Bacterial Epigenetics: The Emerging Roles of Post-Translational Modifications to Nucleoid-Associated Proteins in Shaping Bacterial Chromatin Structure and Gene Regulation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Principles of Chromosome Organization
7:30 pm - 7:50 pm
"Bacterial Chromatin Remodeling Associated with Transcription-Induced Domains at Pathogenicity Islands"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Epigenetics in Archaea: SMC-Mediated Altered Chromosome Conformation is Associated with Resistance to Oxidative Stress in Sulfolobus islandicus "
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Archaeal MC1 Homolog in Mimivirus Orchestrates Genomic DNA Condensation Within Capsids"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Applying Chemical Biology Tools Toward Understanding Histone Monoaminylation and Its Role in Cancer Epigenetics"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Nanoscale Analysis of Human G1 and Metaphase Chromatin In Situ"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Identifying a New Loader for Bacterial SMC Complex"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Forces That Sculpt and Move Chromosomes
9:00 am - 9:20 am
"Replication-Transcription Conflicts"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Peripheral Heterochromatin Tethering and Crosslinking are Required for Chromatin-Based Nuclear Mechanical Response and Sensing"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"On Chicken and Egg: Chromosome Segregation in Pseudomonas Aeruginosa"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Cohesin Loop Extrusion Dynamics Govern Chromatin Compartmentalization"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Investigating Early Embryonic Aneuploidy in the Vertebrate Xenopus Species"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Force Generation by Single Cohesin Molecules"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"ZMYM3 and PTIP Promote ANKRD31-Dependent Chromatin Remodeling and Meiotic DNA Break Formation in the Mouse Pseudoautosomal Region"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Dynamics of Chromosomal and Locus-Specific Copy Number Variations"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosome Dynamics and Human Health
7:30 pm - 7:50 pm
"Chromosome-Specific Centromere Architecture Conserved Across Humans"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Longitudinal Dynamics of Mosaic Chromosomal Alterations from a Prospective Cohort"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Histone H3 Lysine Methyltransferase Activities Control Compartmentalization of Human Centromeres"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Unveiling Centromere Inactivation: A Driver of Genome Instability in Human Aging"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Evolution of Primate Chromosomes"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure