| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cilia Structure and Proteomics |
| Discussion Leader: Jing Zhou (Harvard University) |
| 7:30 pm - 8:00 pm | Susan Dutcher (Washington University, St. Louis)
"Basal body and ciliary comparative proteomics" |
| 8:00 pm - 8:30 pm | Joel Rosenbaum (Yale University)
"Building the cilium" |
| Discussant: Lotte Pederson (Yale University)
“Chlamydomonas intraflagellar transport" |
| 8:30 pm - 9:00 pm | Stephen King (University of Connecticut)
"Dynein arm structure and composition" |
| Discussant: Win Sale (Emory University)
“Regulation of ciliary bending: role of the radial spokes" |
| 9:00 pm - 9:30 pm | Elizabeth Smith (Dartmouth)
"Structural studies of ciliary beat mechanisms" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Function of Non-Motile Cilia |
| Discussion Leader: Matthias Salathe (University of Miami) |
| 9:00 am - 9:30 am | Helle Praetorius (Aarhus University, Denmark)
"Ca2+ in flow measuring cilia" |
| 9:30 am - 10:00 am | Nobutaka Hirokawa (University of Tokyo)
"Function of nodal cilia" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Martina Brueckner (Yale University)
"Flow measurement by nodal cilia and its consequences" |
| 11:00 am - 11:30 am | Martin Blum (University of Hohenheim)
"Cilia and left-right asymmetry in the rabbit embryo" |
| 11:30 am - 12:00 pm | Gregory Pazour (University of Massachusetts)
"Flow measurement by kidney and pancreatic primary cilia and its consequences" |
| 12:00 pm - 12:30 pm | Maureen Barr (University of Wisconsin)
"The KLP-6 Kinesin is required for male mating behaviors and polycystin localization in Caenorhabditise” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cilia as Signaling Organelles |
| Discussion Leader: Peter Satir (Albert Einstein College of Medicine) |
| 7:30 pm - 8:00 pm | Soeren T. Christensen (August Krogh Institute, Denmark)
"Ciliary signaling in control of cell growth and differentiation" |
| Discussant: Kent Hill (UCLA)
“GAS11 is localized to the microtubule organizing center and implicated in dynein regulation” |
| 8:00 pm - 8:30 pm | Friedhelm Hildebrandt (University of Michigan)
"Sensory cilia: A unifying concept for renal cystic disease and retinitis pigmentosa" |
| 8:30 pm - 9:00 pm | Judith Goodship (University of Newcastle on Tyne, UK)
"Inversin in primary cilia and involvement in the cell cycle" |
| Discussant: Cynthia Jensen (University of Auckland)
“The primary cilium -- a mechanotransducer in cartilage cells?” |
| 9:00 pm - 9:30 pm | Danwei Huangfu (Sloan Kettering)
"IFT proteins and mouse Hedgehog signaling" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Primary Ciliary Dyskinesia |
| Discussion Leader: Michael Knowles (University of North Carolina, Chapel Hill) |
| 9:00 am - 9:30 am | Margaret Leigh (University of North Carolina, Chapel Hill)
"Clinical updates: diagnosis and management" |
| 9:30 am - 10:00 am | Estelle Escudier (Faculte de Medecine de Creteil, France)
"Challenges of ciliary ultrastructure as a diagnostic tool in PCD" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Christopher O'Callaghan (Leicester, UK)
"Correlates of defective ciliary structure and function" |
| 11:00 am - 11:30 am | George Witman (University of Massachusetts)
"Lessons from Chlamydomonas: genetics and proteomics" |
| 11:30 am - 12:00 pm | Maimoona Zariwala (University of North Carolina, Chapel Hill)
"Genetics and PCD: current status and future directions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mucins |
| Discussion Leader: John Sheehan (Univ. of North Carolina, Chapel Hill) |
| 7:30 pm - 8:00 pm | David Thornton (University of Manchester, England)
"Biochemistry of mucin and its function in diseases" |
| 8:00 pm - 8:30 pm | Gunnar C. Hansson (Göteborg University, Sweden)
"Biochemistry of mucins and their O-Glycans from normal and CF cell cultures" |
| 8:30 pm - 9:00 pm | Nevis Fregien (University of Miami)
"Glycosylation of mucin core proteins, regulation through Core 2 N-acetylglucosaminyltransferases" |
| 9:00 pm - 9:30 pm | Yin Chen (University of California, Davis)
"Genomic structure of the mucin gene family and their expression" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Mucin Gene Expression |
| Discussion Leader: Reen Wu (University of California, Davis) |
| 9:00 am - 9:30 am | Judith Voynow (Duke University)
"Oxidants as a mediator for mucin gene expression" |
| 9:30 am - 10:00 am | Mary Rose (Children's Research Institute, Washington DC)
"Elevated MUC gene expression as a signature marker for airway diseases" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Hassan Lemjabbar-Alaoui (University of California, San Francisco)
"Signaling transduction pathways involved in mucin gene expression" |
| 11:00 am - 11:30 am | Steven Brody (Washington University)
"Goblet cell hyperplasia" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mucin Secretion and Signaling |
| Discussion Leader: Kenneth B. Adler (North Carolina State University) |
| 7:30 pm - 8:00 pm | Christopher Evans (Baylor College of Medicine)
"Changes in the distribution of mucin production after allergen challenge" |
| 8:00 pm - 8:30 pm | Joungjoa Park (North Carolina State University)
"Novel mechanism of mucin secretion" |
| 8:30 pm - 9:00 pm | Colleen Sweeney (University of California, Davis)
"Role of membrane-associated mucin (MUC4) in epithelial cell proliferation and malignancy" |
| 9:00 pm - 9:30 pm | Sandra Gendler (Mayo Clinic at Scottsdale)
"MUC1 mediated signaling and its function" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Physiology of Airway Surface Liquid (ASL) |
| Discussion Leader: Richard C. Boucher (University of North Carolina, Chapel Hill) |
| 9:00 am - 9:30 am | Michael Rubinstein (University of North Carolina, Chapel Hill)
"Physico-chemical model of airway surface liquid" |
| 9:30 am - 10:00 am | George Caughey (University of California San Francisco)
"Proteases and ENaC function" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Steve Ballard (University of South Alabama)
"Glandular secretions (control and composition)" |
| 11:00 am - 11:30 am | Marcus Mall (University of Heidelberg)
"Mouse model of ASL depletion (is it CF?)" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | What's It All About? - Improving Mucus Clearance In Airway Disease |
| Discussion leader: Gerry Smaldone (SUNY at StonyBrook) |
| 7:30 pm - 8:00 pm | Robert Tarran (University of Nortn carolina Chapel Hill)
"Autoregulation of airway surface liquid volume and mucus clearance by airflow-induced shear stress" |
| Discussant: Rebecca Persinger (Sepracor)
“Mucociliary transport and mucin Secretion are altered by Isomers of beta-agonists“ |
| 8:00 pm - 8:30 pm | William M. Abraham (University of Miami)
"Mucociliary function in the allergic sheep model" |
| 8:30 pm - 9:00 pm | William Bennett (University of North Carolina, Chapel Hill)
"New therapies for correcting mucociliary dysfunction: Human studies" |
| Discussant: Timothy Corcoran (University of Pittsburgh)
“Aerosolized sodium bicarbonate solution and mucociliary clearance in cystic fibrosis” |
| 9:00 pm - 9:30 pm | Claudia L. Ordonez (Harvard University)
"Induced sputum - What can we learn about mucociliary function?" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
