Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Gene Regulation to Functional Aspects of Collagen Biosynthesis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"Transcription Factor Mkx Regulates Tendon Development, Homeostasis and Regeneration"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"CHEVI Complex in Collagen Homeostasis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Effects of Mutations in the Molecular Ensemble for Collagen Biosynthesis"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens as Dynamic Regulators of Networks
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Precise Native Collagen Remodeling Giving Rise to Precise ECM-Cell Crosstalk"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Collagen Triple-Helix Engagement by Two Matrix
Metalloproteinases, with Influences of Exosites"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Monitoring Collagen Fibre Formation and Turnover Using CRISPR/Cas9 Knock-in of Dendra2"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"High Resolution Structure of a C-Propeptides: PCPE Complex Reveals a Mechanism for Substrate-Specific Enhancement of Procollagen Processing by BMP-1"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Lysyl Oxidase Like-2 (LOXL2) Regulates 3D Vascular Morphogenesis Through Scaffolding of Basement Membrane"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Photoactivatable HSP47: An Optogenetic Tool to Regulate Collagen Assembly and Related Disorders"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Probing Modifications of Collagen Fibrils by DNP-Enhanced Solid-State NMR"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cells in Collagen Microenvironments
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Impact of Fibroblast Heterogeneity on Dermal Extracellular Matrix"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Cancer Cell Invasion and Tissue Remodeling In Vivo "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"The Role of Col11α1 in Cancer Progression and Fibrosis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"An Extracellular Matrix Signature in Leukemia Precursor Cells and Acute Myeloid Leukemia"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens of the Basement
Membrane Zone: Assembly and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Evolution of Collagen IV and Basement Membrane Enabling Multicellularity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"B-LINK: A Basement Membrane Adhesion System for Connecting Tissues Together"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:15 am
"Collagens in the Glomerular Basement Membrane in Health and Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"More than Meets the Eye: Widening the Implications of Type VII Collagen Deficiency"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Targeting Intracellular Consequences of Collagen IV Mutations"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Mapping the ECM Specific to the Sites of Inter-Tissue Interactions in the Hair Follicles"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Collagens in Ageing and Metabolism
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Prolonged Extracellular Matrix Homeostasis Promotes Healthy Aging"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Collagen XVIII Regulates Energy Metabolism and Brown Adipose Tissue Function"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Extracellular Matrix Remodelling and Stem Cell Proliferation: In Search of the Missing Link"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Impact of Ageing on TGF-β Stimulated Type I Collagen Production"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens in Development and Tissue Regeneration
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Role of Collagen 4a5 in Peripheral Nerve Regeneration"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Muscle Stem Cell Regulation of Extracellular Matrix During Skeletal Muscle Development and Repair"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Collagen XIV as a New Regulator of Basement Membrane Biomechanics During Zebrafish Caudal Fin Regeneration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Control and Functions of Collagens in Successful Spinal Cord Regeneration in the Zebrafish"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Collagen IV Crosslinking Is Required for Basement Membrane Repair After DSS Damage in Drosophila "
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Insights into Function of the Alpha6 Chain of Collagen VI from the Col6a6-Null Mouse"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Loss of Fibulin-4 Results in Abnormal Collagen Fibril Assembly in Bone"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
3D Bioengineering and Mechanobiology
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Mechanical Cellular Dynamics Within Diverse 3D Collagen Microenvironments"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Impact of Non-Linear Elasticity and Plasticity of Collagen Networks on Cancer Metastasis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"The Use of Collagen in Tissue Engineered Scaffolds
for Tissue Replacement and Disease Models"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Synthesis and Degradation of Collagenous ECM in Ligament-Derived Stem Cells and Fibroblasts"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Collagens
in Inherited and Common Diseases and Therapies
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Dysfunctional Collagen V Regulation in Classic EDS Results in Abnormal Structure and Function of Tendons and Ligaments"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Profiling the Collagen Landscape of Normal and Diseased Tissues Using Proteomics"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Hsp47, a Hub of the ECM Network, in Breast Cancer Progression"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Targeting Cellular Stress in Osteogenesis Imperfecta Zebrafish Models Ameliorates Bone Phenotype"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Human Induced Pluripotent Stem Cell Models of Inherited Collagen Diseases – Mechanistic Insights and Therapies"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Defective RIP Due to Mutations in MBTPS2 Results in Altered Collagen Hydroxylation and Crosslinking and Causes OI Type XVIII"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Modulation of Cancer Cell Behavior by Collagen Fibril Characteristics and Tissue Interfaces"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technological Advances and Emerging Directions for
Collagen Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Systematic Analysis of Extracellular Protease Networks by Advanced Degradomics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"In Situ Detection of Degraded and Denatured Collagen via Triple Helical Hybridization: From Histology to In Vivo Imaging"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Ex Vivo Multiscale Quantitation of Skin and Cornea Biomechanics Using Multiphoton Microscopy"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Di-Iodotyrosinated Peptide Imaging of Cartilage (DIPIC)"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure