A major focus of craniofacial research is to improve understanding of the etiology of craniofacial malformations, to develop diagnostics and therapies for these disorders, and to effectively repair craniofacial tissues. Contemporary studies of the craniofacial complex employ a multidisciplinary approach that combines developmental biology, functional genomics, biochemistry, biophysics, molecular biology and cellular biology. The study of craniofacial development utilizes a variety of vertebrate species, including those that are not commonly used for laboratory studies. Collectively, these models provide a range of experimental approaches to investigate the molecular and cellular mechanisms directing the morphogenesis of the craniofacial tissues and associated organs in health and disease. They also offer insight into the evolutionary forces and environmental factors driving the diversity of form and function of these highly complex structures. The scientific program will feature a wide range of topics to highlight how interdisciplinary research has enabled us to push boundaries in our understanding of craniofacial research, including talks investigating the physics and mechanics of craniofacial development and regeneration. Using such approaches, researchers can address how craniofacial cell populations work together, and how the surrounding environment impacts on form. Scientific presentations will be accompanied by discussions on how these processes drive tissue diversity and shape of craniofacial structures, and how distinctive features of the vertebrate head have evolved. Invited presentations by leading researchers and clinician scientists in the field will present new findings in craniofacial morphogenesis and regeneration, with specific focus on the role that mechanics plays in shaping development. The meeting will provide opportunities for junior scientists and graduate students to present their work in oral and poster format, and exchange ideas with leaders in the field. Selected poster presenters will be invited to present short talks. The meeting will feature sessions on cell signaling, clinical genetics, sense organs, development of animal models of craniofacial disorders, state-of-the-art imaging techniques, and the use of tissue engineering approaches for regenerative repair of craniofacial tissues. The program will bring together basic and clinician scientist researchers of diverse expertise to foster stimulating discussions and productive collaborations across related fields in a highly interdisciplinary manner. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides a venue for scientists from a variety of disciplines to brainstorm and promote cross-disciplinary collaborations in these research areas.