Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cyclic Nucleotide Signaling Pathways: From Receptors to Targets
Discussion Leader: David Kass (Johns Hopkins University School of Medicine, United States)
7:40 pm - 8:00 pm
Carmen Dessauer (University of Texas Health Science Center at Houston, United States)
"Unique Scaffolding of Adenylyl Cyclase in Heart"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Martin Lohse (Max Delbrück Center for Molecular Medicine, Germany)
"Nanometer-Sized Signaling Compartments of cAMP"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Martina Schmidt (University of Groningen, The Netherlands)
"Non-Canonical Cyclic Nucleotide Signaling: Missing Link to Neuroinflammation in the Lung and Brain"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
"Structure and Function of Membrane Adenylyl Cyclases"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spatiotemporal Regulation of Cyclic Nucleotide Signaling
Discussion Leader: Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
9:00 am - 9:20 am
Manuela Zaccolo (University of Oxford, United Kingdom)
"Targeting cAMP Nanodomains for Precision Therapy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Scott (University of Washington School of Medicine, United States)
"Exploring and Exploiting the Spatial Constraints of cAMP Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Aldebaran Hofer (Harvard Medical School and VA Boston Healthcare System, United States)
"cAMP Signaling Microdomain of the Primary Cilium"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Gomelsky (University of Wyoming, United States)
"Remote Control of cAMP Signaling in Mammals via Near-Infrared Light-Activated Enzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Andreas Bock (Rudolf-Boehm-Institute of Pharmacology, Medical Faculty, Leipzig University, Germany, Germany)
"PDEs Define a cAMP Signaling Nanoarchitecture in Intact Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jason Zhang (University of Washington, United States)
"Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Paula Krieg (University Medical Center Hamburg-Eppendorf (UKE), Germany)
"PDE2A-Mediated cGMP/cAMP Cross-Talk Modulates Autoreactive T cell Activity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kjetil Andressen (University of Oslo, Norway)
"Natriuretic Peptides Increase cGMP around Cardiomyocyte Mitochondria and Protect against Apoptosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Michy Kelly (University of Maryland School of Medicine, United States) and Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural, Molecular and Systems Dissection of PDE Signaling
Discussion Leader: Nikolai Artemyev (University of Iowa, United States)
6:00 pm - 6:20 pm
Robert Harvey (University of Nevada, Reno, United States)
"Spatiotemporal Aspects of cAMP Signaling in Cardiac Myocytes"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Rick Cote (University of New Hampshire, United States)
"Molecular Architecture and Allosteric Regulation of PDE6 in its Nonactivated and Activated States: Therapeutic Implications for Retinal Degenerative Diseases"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Late-Breaking Topic
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Ester Paolocci (University of Oxford, United Kingdom)
"The Role of Phosphodiesterases in the Primary Cilium and Ciliopathies"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jeremy Eberhard (Boston College, United States)
"Characterization of PDEs Inhibitors Using a Schizosaccharomyces Pombe Screening Platform"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cyclic Nucleotide Signaling in Cardiovascular Systems
Discussion Leader: Rodolphe Fischmeister (Université Paris-Saclay, France)
9:00 am - 9:20 am
Yang Xiang (University of California, Davis, United States)
"Internal Beta1AR Signaling in Cardiac EC Coupling and Beyond"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Grégoire Vandecasteele (INSERM / University Paris-Saclay, France)
"The RIa Subunit of cAMP-Dependent Protein Kinase is a Critical Negative Regulator of Cardiac Inotropy, Chronotropy and Arrhythmias"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Julia Gorelik (Imperial College London, United Kingdom)
"Functional LTCC-ß2AR Complexes in the T-Tubules Requires Caveolin-3 and are Disrupted During Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Late-Breaking Topic
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
David Kass (Johns Hopkins University School of Medicine, United States)
"Treating Cardiometabolic Syndrome with PDE9 Inhibition"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Maria Ercu (Max-Delbrück-Centrum für Molekulare Medizin, Anchored Signalling department, Germany)
"Phosphodiesterase 3A Mutations Protect from Cardiac Damage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Grace Muller (Loyola University Chicago, United States)
"Phosphodiesterase 1 (PDE1) modulates cAMP signaling at the sarcolemmal membrane"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel and Atypical Signaling
Discussion Leader: Manuela Zaccolo (University of Oxford, United Kingdom)
6:00 pm - 6:20 pm
Roland Seifert (Hannover Medical School, Germany)
"Signaling via cCMP and cUMP"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Nikolai Artemyev (University of Iowa, United States)
"Maturation of Phosphodiesterase 6 by the Complex of HSP90 with AIPL1"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Thomas Brand (Imperial College London, United Kingdom)
"Heteromeric Interaction of POPDC Proteins Is Essential for Membrane Trafficking"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Frank Lezoualc'h (Institute of Metabolic and Cardiovascular Diseases, INSERM UMR-1297, University of Toulouse, France)
"Palmitoylation-Dependent Activation of Soluble Adenylyl Cyclase Promotes Cardiomyocyte Death"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Elka Kyurkchieva (University of Glasgow, United Kingdom)
"Targeted Degradation of Short and Super-short PDE4 Isoforms Using Bifunctional Protein Degraders"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Selective PDE Targeting of Central Nervous System Functions
Discussion Leader: Michy Kelly (University of Maryland School of Medicine, United States)
9:00 am - 9:20 am
Achim Schmidtko (Goethe University Frankfurt, Germany)
"Functions of Phosphodiesterases in Pain Processing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pierre Vincent (CNRS, France)
"Functional Contribution of Phosphodiesterase Activities in Striatal Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jacob Nielsen (Lundbeck, Denmark)
"Molecular Mechanism of PDE1 Activation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hanting Zhang (Qingdao University School of Pharmacy, China)
"PDE7: A Novel Target for CNS Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Holger Rosenbrock (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
"Effects of the Novel Phosphodiesterase-2 Inhibitor BI 474121 on Mouse Auditory Event-Related Potentials Biomarkers and Rodent Cognition Tasks Related to Schizophrenia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Fernando Padovan Neto (University of São Paulo, Brazil)
"Phosphodiesterase 10A (PDE10A) in L-DOPA-Induced Dyskinesias"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ying Xu (Rutgers, The State University of New Jersey, United States)
"Targeting Mitochondria-Localized Phosphodiesterase 2A for Treatment of Alzheimer’s Disease and Mild Cognitive Impairment"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Emily Willems (Maastricht University - School for Mental Health and Neuroscience, The Netherlands)
"Specific Inhibition of Phosphodiesterase 4D Long Isoforms Improves Neuronal Plasticity and Protects Against Aß Toxicity In Vitro"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
PDEs in Vascular and Metabolic Processes
Discussion Leader: Paul Epstein (UConn Health, United States)
6:00 pm - 6:20 pm
Andrea Isidori (Sapienza University of Rome, Italy)
"Vascular Inflammation and Metabolic Effects of Selective PDE-5 inhibition: Experimental and Clinical Studies"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Anders Tengholm (Uppsala University, Sweden)
"Cyclic AMP Signaling in Islet Hormone Secretion"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Alexander Pfeifer (University of Bonn, Germany)
"Control of Cyclic Nucleotides in Adipocytes"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Kirstie De Jong (Institute of Experimental Cardiovascular Research. University Medical Center, Hamburg-Eppendorf, Germany)
"Live Cell Imaging Identifies Novel cAMP Microdomains Regulating ß-adrenoceptor Subtype Specific Lipolytic Responses in Human White Adipocytes Driven by Distinct PDE Coupling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Leila Gobejishvili (University of Louisville, United States)
"Pleiotropic Roles of Phosphodiesterase 4 in Hepatic Inflammatory and Fibrotic Processes in Humans and Mice"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
PDE Mediated Signaling in Immunological and Inflammatory Processes
Discussion Leader: Joseph Beavo (University of Washington, United States)
9:00 am - 9:20 am
Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
"PDE1 Inhibitors in the Treatment of Neuroinflammation and Cancer: Targeting Tumor-Associated Macrophages as a Strategy to Enhance the Response to Immune Checkpoint Inhibitors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tim Vanmierlo (Hasselt University / Maastricht University, Belgium)
"Phosphodiesterase 4D Inhibition boosts Remyelination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stefan Brocke (UConn Health, United States)
"Cyclic Nucleotide Phosphodiesterase 8 as a Target to Treat Autoimmune Inflammation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kjetil Tasken (Oslo University Hospital, Norway)
"Cyclic AMP Regulation of Gap Junction Conductivity and Invasiveness of Glioblastoma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ralf Hoffmann (Philips Research / University of Glasgow, The Netherlands)
"The Role of PDE4D7 in Aggressive Prostate Cancer and its Potential Link to the Innate and Adaptive Immune Response"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Roberta Kurelic (University Medical Center Hamburg-Eppendorf, Germany)
"Regulation of Cyclic-Nucleotide Cross-Talk in CD4+ T Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Christian Hesslinger (Boehringer Ingelheim Pharma GmbH & Co KG, Germany)
"PDE4B Inhibitor (BI 1015550) for Fibrotic Lung Diseases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Therapeutic Considerations and Path to the Clinic
Discussion Leader: Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
6:00 pm - 6:20 pm
Coleen Atkins (University of Miami, United States)
"Treating Synaptic Loss in Traumatic Brain Injury with a PDE4B Allosteric Inhibitor"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
George Baillie (University of Glasgow, United Kingdom)
"Selective Silencing of Phosphodiesterase type 4D Short-Forms using "First-in-Class" PDE4 PROTACS"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Peter Sandner (Bayer AG, Pharmaceuticals, Germany)
"Enhancing cGMP Signaling Beyond PDE Inhibition: Discovery, Development and Therapeutic Use of sGC Stimulators and sGC Activators"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure