Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Cyclic Nucleotide Signaling Pathways: From Receptors to Targets
Discussion Leader: David Kass (Johns Hopkins University School of Medicine, USA)
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7:40 pm - 8:00 pm |
Carmen Dessauer (University of Texas Health Science Center at Houston, USA)
"Unique Scaffolding of Adenylyl Cyclase in Heart"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:30 pm |
Martin Lohse (Max Delbrück Center for Molecular Medicine, Germany)
"Nanometer-Sized Signaling Compartments of cAMP"
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8:30 pm - 8:40 pm |
Discussion
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8:40 pm - 9:00 pm |
Martina Schmidt (University of Groningen, The Netherlands)
"Non-Canonical Cyclic Nucleotide Signaling: Missing Link to Neuroinflammation in the Lung and Brain"
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9:00 pm - 9:10 pm |
Discussion
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9:10 pm - 9:25 pm |
Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
"Structure and Function of Membrane Adenylyl Cyclases"
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9:25 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Spatiotemporal Regulation of Cyclic Nucleotide Signaling
Discussion Leader: Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
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9:00 am - 9:20 am |
Manuela Zaccolo (University of Oxford, United Kingdom)
"Targeting cAMP Nanodomains for Precision Therapy"
|
9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
John Scott (University of Washington School of Medicine, USA)
"Exploring and Exploiting the Spatial Constraints of cAMP Signaling"
|
9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Aldebaran Hofer (Harvard Medical School and VA Boston Healthcare System, USA)
"cAMP Signaling Microdomain of the Primary Cilium"
|
10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Mark Gomelsky (University of Wyoming, USA)
"Remote Control of cAMP Signaling in Mammals via Near-Infrared Light-Activated Enzymes"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Short Talk Selected from Poster Abstracts
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Short Talk Selected from Poster Abstracts
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Short Talk Selected from Poster Abstracts
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Group Photo / Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Michy Kelly (University of Maryland School of Medicine, USA) and Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
|
4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
Structural, Molecular and Systems Dissection of PDE Signaling
Discussion Leader: Nikolai Artemyev (University of Iowa, USA)
|
6:00 pm - 6:20 pm |
Robert Harvey (University of Nevada, Reno, USA)
"Spatiotemporal Aspects of cAMP Signaling in Cardiac Myocytes"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Rick Cote (University of New Hampshire, USA)
"Molecular Architecture and Allosteric Regulation of PDE6 in its Nonactivated and Activated States: Therapeutic Implications for Retinal Degenerative Diseases"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Ganesh Anand (Penn State University, USA)
"Cyclic AMP Channeling in PDE8-PKA RIa Complexes: Implications for Signal Adaptation"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Short Talk Selected from Poster Abstracts
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Short Talk Selected from Poster Abstracts
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Cyclic Nucleotide Signaling in Cardiovascular Systems
Discussion Leader: Rodolphe Fischmeister (Université Paris-Sud, France)
|
9:00 am - 9:20 am |
Chen Yan (University of Rochester, USA)
"cAMP: A Friend or Foe of the Heart?"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Yang Xiang (University of California, Davis, USA)
"Internal Beta1AR Signaling in Cardiac EC Coupling and Beyond"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Xiaodong Cheng (University of Texas Health Science Center at Houston, USA)
"Spatiotemporal Regulation of cAMP/EPAC Signaling"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Christina Kruuse (University of Copenhagen, Herlev Gentofte Hospital, Denmark)
"PDEs in Cerebrovascular Disease from a Clinical Perspective"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
David Kass (Johns Hopkins University School of Medicine, USA)
"Treating Cardiometabolic Syndrome with PDE9 Inhibition"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Stephen Yarwood (Heriot-Watt University, United Kingdom)
"Development of Small Molecule Epac1 Activators"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Novel and Atypical Signaling
Discussion Leader: Manuela Zaccolo (University of Oxford, United Kingdom)
|
6:00 pm - 6:20 pm |
Roland Seifert (Hannover Medical School, Germany)
"Signaling via cCMP and cUMP"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Nikolai Artemyev (University of Iowa, USA)
"Maturation of Phosphodiesterase 6 by the Complex of HSP90 with AIPL1"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:15 pm |
Short Talk Selected from Poster Abstracts
|
7:15 pm - 7:25 pm |
Discussion
|
7:25 pm - 7:40 pm |
Short Talk Selected from Poster Abstracts
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Short Talk Selected from Poster Abstracts
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Selective PDE Targeting of Central Nervous System Functions
Discussion Leader: Michy Kelly (University of Maryland School of Medicine, USA)
|
9:00 am - 9:20 am |
Achim Schmidtko (Goethe University Frankfurt, Germany)
"Functions of Phosphodiesterases in Pain Processing"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Dorit Ron (University of California, San Francisco, USA)
"Cellular and Signaling Specificity of Alcohol’s Action in the Brain"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Pierre Vincent (Sorbonne Université, France)
"Functional Contribution of Phosphodiesterase Activities in Striatal Neurons"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Jacob Nielsen (Lundbeck, Denmark)
"Molecular Mechanism of PDE1 Activation"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Fernando Padovan Neto (University of São Paulo, Brazil)
"Phosphodiesterase 10A (PDE10A) in L-DOPA-Induced Dyskinesias"
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Ying Xu (Rutgers, The State University of New Jersey, USA)
"Targeting Mitochondria-Localized Phosphodiesterase 2A for Treatment of Alzheimer’s Disease and Mild Cognitive Impairment"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Hanting Zhang (Qingdao University School of Pharmacy, China)
"PDE7: A Novel Target for CNS Diseases"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
PDEs in Vascular and Metabolic Processes
Discussion Leader: Enno Klussmann (Max-Delbrück-Center for Molecular Medicine (MDC) Berlin, Germany)
|
6:00 pm - 6:20 pm |
Donald Maurice (Queen's University, Canada)
"Local Coupling of Ca2+ and cAMP Signaling in Cells of the Cardiovascular System"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Mary Anna Venneri (Sapienza University of Rome, Italy)
"Vascular Inflammation and Metabolic Effects of Selective PDE-5 inhibition: Experimental and Clinical Studies"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Anders Tengholm (Uppsala University, Sweden)
"Cyclic AMP Signaling in Islet Hormone Secretion"
|
7:20 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:50 pm |
Alexander Pfeifer (University of Bonn, Germany)
"Control of Cyclic Nucleotides in Adipocytes"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
PDE Mediated Signaling in Immunological and Inflammatory Processes
Discussion Leader: Joseph Beavo (University of Washington, USA)
|
9:00 am - 9:20 am |
Hai-Bin Luo (Sun Yat-sen University, China)
"New Medicinal Chemistry Strategies for Discovering Novel PDE Inhibitors"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Gretchen Snyder (Intra-Cellular Therapies Inc, USA)
"PDE1 Inhibitors in the Treatment of Neuroinflammation and Cancer"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Stefan Brocke (UConn Health, USA)
"Cyclic Nucleotide Phosphodiesterase 8 as a Target to Treat Autoimmune Inflammation"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Kjetil Tasken (Oslo University Hospital, Norway)
"Cyclic AMP Regulation of Gap Junction Conductivity and Invasiveness of Glioblastoma"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Ralf Hoffmann (Philips Research / University of Glasgow, The Netherlands)
"The Role of PDE4D7 in Aggressive Prostate Cancer and its Potential Link to the Innate and Adaptive Immune Response"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Tim Vanmierlo (Hasselt University / Maastricht University, Belgium)
"Phosphodiesterase 4D Inhibition boosts Remyelination"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Christian Hesslinger (Boehringer Ingelheim Pharma GmbH & Co KG, Germany)
"PDE4B inhibitor (BI 1015550) for Fibrotic Lung Diseases"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Therapeutic Considerations and Path to the Clinic
Discussion Leader: Gretchen Snyder (Intra-Cellular Therapies Inc, USA)
|
6:00 pm - 6:20 pm |
Coleen Atkins (University of Miami, USA)
"Treating Synaptic Loss in Traumatic Brain Injury with a PDE4B Allosteric Inhibitor"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
George Baillie (University of Glasgow, United Kingdom)
"Selective Silencing of Phosphodiesterase type 4D Short-Forms using "First-in-Class" PDE4 PROTACS"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:10 pm |
Short Talk Selected from Poster Abstracts
|
7:10 pm - 7:15 pm |
Discussion
|
7:15 pm - 7:25 pm |
Short Talk Selected from Poster Abstracts
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Short Talk Selected from Poster Abstracts
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 8:00 pm |
Closing Remarks
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|