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Saturday
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| 2:00 pm - 5:00 pm |
Arrival and Check-in
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| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:45 pm - 4:30 pm |
Keynote Session: The Multifaceted Nature of cAMP Compartmentalization
Discussion Leader: Bracy Fertig (University of Glasgow, United Kingdom)
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| 3:45 pm - 4:20 pm |
Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Spatial Constraints of Adenylyl Cyclase Signaling"
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| 4:20 pm - 4:30 pm |
Discussion
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| 4:30 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Phosphodiesterases as Therapeutic Targets
Discussion Leader: Si Chen (University of Rochester, USA)
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| 7:30 pm - 7:45 pm |
Michael Preedy (The William Harvey Research Institute, United Kingdom)
"Inhibition of Phosphodiesterase (PDE) 2 Reverses the Development of Experimental Heart Failure by Promoting NO/GC-1/cGMP Signaling"
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| 7:45 pm - 7:50 pm |
Discussion
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| 7:50 pm - 8:05 pm |
Jonas Skogestad (Oslo University Hospital, Norway)
"Phosphodiesterase 2 Inhibition Activates the Na+/K+-ATPase and Prevents Ventricular Tachycardia"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Grace Kim (Johns Hopkins University, USA)
"Acute Enhancement of Cardiac Function by PDE1 Inhibition in the Dog and Rabbit Show Targeted cAMP Signaling Distinct from Beta-Receptor Agonism"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Chongyang Zhang (University of Rochester, USA)
"The Role of PDE1C in Vascular Smooth Muscle Senescence and Abdominal Aortic Aneurysm"
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Dean Paes (Maastricht University, The Netherlands)
"Disentangling Which PDE4D Isoform to Target in Alzheimer's Disease"
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| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:25 pm |
Kevin Schuster (University of New Hampshire, USA)
"Physiological Consequences and Comparative Pharmacology of Inhibiting Nematode Phosphodiesterase Activity"
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| 9:25 pm - 9:30 pm |
Discussion
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
Complexity of Phosphodiesterase Regulation in Cyclic Nucleotide Signaling
Discussion Leader: Michael Preedy (The William Harvey Research Institute, United Kingdom)
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| 9:00 am - 9:15 am |
Amy Tibbo (University of Glasgow, United Kingdom)
"Compartmentalized cAMP Signalling via the PDE4-POPeye Protein Complex"
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| 9:15 am - 9:20 am |
Discussion
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| 9:20 am - 9:35 am |
Nadja Bork (University Medical Center Hamburg Eppendorf, Germany)
"Changes in Cardiomyocyte cGMP Dynamics During Hypoxia/Reoxygenation"
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| 9:35 am - 9:40 am |
Discussion
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| 9:40 am - 9:55 am |
Ariana Jacobs (Queen's University, Canada)
"Differential Influence of Phosphodiesterase 1C on Human Arterial Smooth Muscle Cell Migration and Invasion"
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| 9:55 am - 10:00 am |
Discussion
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| 10:00 am - 10:15 am |
Lingfeng Luo (University of Rochester, USA)
"Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling"
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| 10:15 am - 10:20 am |
Discussion
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| 10:20 am - 10:35 am |
Kaitlyn Pilarzyk (School of Medicine, University of South Carolina, USA)
"The Role of PDE11A4 in Isolation-Induced Neuroinflammation"
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| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 10:55 am |
Melissa Schepers (Hasselt University, Belgium)
"The Phosphodiesterase 4 (PDE4) Inhibitor Roflumilast Improves Remyelination in a Mouse Model for Multiple Sclerosis"
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| 10:55 am - 11:00 am |
Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: How to Sell Your Story
Discussion Leaders: Lise Moltzau (University of Oslo, Norway) and Ellanor Whiteley (University of Glasgow, United Kingdom)
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| 1:30 pm - 2:30 pm |
Panel Discussion
Experiences from Our Own Careers
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Rodolphe Fischmeister (Université Paris-Sud, France)
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Michy Kelly (School of Medicine, University of South Carolina, USA)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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