Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Multifaceted Nature of cAMP Compartmentalization
Discussion Leader: Bracy Fertig (University of Glasgow, United Kingdom)
3:45 pm - 4:20 pm
Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Spatial Constraints of Adenylyl Cyclase Signaling"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phosphodiesterases as Therapeutic Targets
Discussion Leader: Si Chen (University of Rochester, USA)
7:30 pm - 7:45 pm
Michael Preedy (The William Harvey Research Institute, United Kingdom)
"Inhibition of Phosphodiesterase (PDE) 2 Reverses the Development of Experimental Heart Failure by Promoting NO/GC-1/cGMP Signaling"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Jonas Skogestad (Oslo University Hospital, Norway)
"Phosphodiesterase 2 Inhibition Activates the Na+/K+-ATPase and Prevents Ventricular Tachycardia"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Grace Kim (Johns Hopkins University, USA)
"Acute Enhancement of Cardiac Function by PDE1 Inhibition in the Dog and Rabbit Show Targeted cAMP Signaling Distinct from Beta-Receptor Agonism"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Chongyang Zhang (University of Rochester, USA)
"The Role of PDE1C in Vascular Smooth Muscle Senescence and Abdominal Aortic Aneurysm"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Dean Paes (Maastricht University, The Netherlands)
"Disentangling Which PDE4D Isoform to Target in Alzheimer's Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Kevin Schuster (University of New Hampshire, USA)
"Physiological Consequences and Comparative Pharmacology of Inhibiting Nematode Phosphodiesterase Activity"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Complexity of Phosphodiesterase Regulation in Cyclic Nucleotide Signaling
Discussion Leader: Michael Preedy (The William Harvey Research Institute, United Kingdom)
9:00 am - 9:15 am
Amy Tibbo (University of Glasgow, United Kingdom)
"Compartmentalized cAMP Signalling via the PDE4-POPeye Protein Complex"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Nadja Bork (University Medical Center Hamburg Eppendorf, Germany)
"Changes in Cardiomyocyte cGMP Dynamics During Hypoxia/Reoxygenation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ariana Jacobs (Queen's University, Canada)
"Differential Influence of Phosphodiesterase 1C on Human Arterial Smooth Muscle Cell Migration and Invasion"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Lingfeng Luo (University of Rochester, USA)
"Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Kaitlyn Pilarzyk (School of Medicine, University of South Carolina, USA)
"The Role of PDE11A4 in Isolation-Induced Neuroinflammation"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Melissa Schepers (Hasselt University, Belgium)
"The Phosphodiesterase 4 (PDE4) Inhibitor Roflumilast Improves Remyelination in a Mouse Model for Multiple Sclerosis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How to Sell Your Story
Discussion Leaders: Lise Moltzau (University of Oslo, Norway) and Ellanor Whiteley (University of Glasgow, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Experiences from Our Own Careers
Rodolphe Fischmeister (Université Paris-Sud, France)
Michy Kelly (School of Medicine, University of South Carolina, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
