Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Compartmentalized cAMP Signalling: Challenges and Opportunities
Discussion Leader: Melissa Schepers (Hasselt University - Maastricht University, Belgium)
3:45 pm - 4:15 pm
Manuela Zaccolo (University of Oxford, United Kingdom)
"Compartmentalized cAMP Signalling: Challenges and Opportunities"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Function and Regulation of Cyclic Nucleotide Signalling Pathways and Novel Methods for Unraveling Them
Discussion Leader: Si Chen (University of Rochester, United States)
7:30 pm - 7:45 pm
Lisa Maria Martin (Leipzig University, Germany)
"POPDC Proteins as Novel Regulators of Compartmentalized GPCR/cAMP Signaling"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Sanika Mohagaonkar (Universitätsklinikum Hamburg-Eppendorf, University of Hamburg, Germany)
"Molecular Mechanisms of Atrial Natriuretic Peptide Effect on Adrenal Aldosterone Secretion"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Janvi Patel (Kelly Lab, SOM, University of Maryland, United States)
"Effects of Strain, Species and Import Stress on Age-related Accumulation of PDE11A4 in Ghost Axons and Subsequent Cognitive Decline of Social Memory"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Thomas Wright (University of Glasgow, United Kingdom)
"The Phosphodiesterase Spliceosome in Colorectal Cancer by RNA-Seq"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Sofia Possidento (University of Connecticut, United States)
"mAKAPß Mediated Regulation of a Calcium Microdomain"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Aurélien Barthou (INSERM DR Paris IDF Sud, France)
"Absence of the Regulatory Subunit RIa of PKA Alters cAMP Compartmentation in Adult Mice Ventricular Myocytes"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Targeting PDE Signaling in Degenerative Disorders, Aging, and Disease
Discussion Leader: Aurélien Barthou (INSERM DR Paris IDF Sud, France)
9:00 am - 9:15 am
Melissa Schepers (Hasselt University - Maastricht University, Belgium)
"Selective PDE4 Subtype Inhibition Provides New Opportunities to Intervene in Neuroinflammatory Versus Myelin Damaging Hallmarks of Multiple Sclerosis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Mary Nancy Walter (University of Louisville, United States)
"Beneficial Effects of Phosphodiesterase 4 Inhibition on Alcohol-Induced Dysbiosis and the Progression of Alcohol-Associated Steatohepatitis (ASH)"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Mikayla Erdelsky (Queen's University, Canada)
"Phosphodiesterase 4 Activity Uniquely Regulates Ciliary cAMP-Dependent 3T3-L1 Adipogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Connor Blair (University of Glasgow, United Kingdom)
"Disrupting the c-RAF - PDE8A PPI as a Differentiated Approach to Treating KRAS - c-RAF Driven Pancreatic Cancer"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Si Chen (University of Rochester, United States)
"Unveiling the Novel Therapeutic Role of PDE10A-Mediated Functional Protein Complex in Cardiac Hypertrophy"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Maira Ahmed (Boston College, United States)
"Investigating Putative Small Inhibitors of Mammalian Transmembrane Adenylyl Cyclases"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Academic Growth and the Transition from Academia to Industry
Discussion Leader: Connor Blair (University of Glasgow, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Academic Growth and the Transition from Academia to Industry
Andreas Bock (Leipzig University, Medical Faculty, Germany)
Michy Kelly (University of Maryland School of Medicine, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes