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Cytoskeletal Motors

Gordon Research Conference

Cytoskeletal Motors from Structure to Mechanism to Disease

July 8 - 13, 2018

Chair

Vice Chair

Conference Description

The 2018 GRC on Cytoskeletal Motors continues a tradition of more than 50 years of GRCs focused on how molecular motors work. This meeting has a strong history of uniting biophysicists, structural biologists, and cell biologists and is a premier venue for highlighting the newest and most exciting research in the field.

This meeting will bring together leaders in the field studying the mechanism of myosin, kinesin and dynein motors. A major focus will also be on how each of these motors interacts with its track (actin filaments or microtubules) and how track dynamics or modifications affect motor function.

Cytoskeletal motors also play an important role in normal human physiology and their dysfunction is involved in a wide range of diseases. This conference will have sessions on how defects in the cytoskeleton play a role in cardiovascular and muscle disease, cancer, and neurological disease.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Motors, Tracks, and How Their Interactions Drive Their Functions Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:20 pm	"Visualizing Interactions that Regulate Microtubule Dynamics"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 8:40 pm	Introduction by Discussion Leader
8:40 pm - 9:15 pm	"Guarding the Genome: Chromosome Motors, Aneuploidy and Tumorigenesis"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motor Structure and Mechanism Discussion Leader:
9:00 am - 9:20 am	"Cryo-EM Structures of Dynein/Dynactin Complexes"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Single-Molecule Dissection of Cytoplasmic Dynein Tension Sensing"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Single Molecule Reconstitution of a Microtubule-Based mRNA Transport Complex"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Conservation and Specialization of Kinesin Motor Mechanisms"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Mechanism of Microtubule Depolymerization by Kinesin-13s"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Tip-Enriched Adhesion Alters the Morphology and Dynamics of Actin-Based Protrusions"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Structural Plasticity at the Actin-Myosin Interface"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Motors in Cardiovascular and Muscle Disease Discussion Leader:
7:30 pm - 7:50 pm	"Biochemistry and Biophysics of Purified Human Beta-Cardiac Myosin Carrying Hypertrophic Cardiomyopathy Mutations"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Discovering Sarcomere Function from Analyses of Human Mutations"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Mavacamten Stabilizes an Autoinhibited State of Two-Headed Cardiac Myosin"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Spectroscopic Probes of Motors in Therapeutic Discovery"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Tracks: Structure, Dynamics and Interactions with Motors Discussion Leader:
9:00 am - 9:20 am	"The Tubulin Code: How Cells Build Specificity into Microtubule Networks"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Biomolecular Condensation of the Microtubule Nucleation Effector TPX2 Enhances Reaction Kinetics In Vivo"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"A Tail-Motor Domain Interaction Regulates Kinesin-5 Antiparallel Microtubule Sliding Motility"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Self-Organization of Mitotic Motors and Dynamic Microtubules In Vitro"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Lattice Gating by Microtubule-Associated Proteins Controls Motor Activity"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Rapid Actin Filaments Remodeling via Oxidation by Mical Family Enzymes"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Rapid Rerouting of Myosin Traffic at the T Cell Immune Synapse"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Load Adaptation of an Actin Network Motor"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Recent Breakthroughs in Cytoskeletal Research Discussion Leader:
7:30 pm - 7:50 pm	"Understanding Familial Cardiomyopathies from the Ground Up"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"MyTH4-FERM Myosin and VASP Cooperation During Filopodia Initiation"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Structural Basis for Isoform-Specific Kinesin-1 Recognition of Y-Acidic Cargo Adaptors"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"The Structure of C. elegans Microtubules In Vivo and In Vitro and Its Implication for Motor Proteins"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Dynamic Instability of Microtubule Minus Ends"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"A Primary Cilium Architect: How Kif7 Fine-Tunes Microtubule Length"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motor Engineering and Reconstituted Systems Discussion Leader:
9:00 am - 9:20 am	"Design, Performance and Applications of Controllable Cytoskeletal Motors"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Biophysical Regulation of Myosin VI Motility by Cargo Adaptor Proteins"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Differential Actin-Binding Affinity Leads to Sorting and Specific Clustering in a Reconstituted, Active Acto-Myosin-Membrane Composite Layer"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"MAP7 Regulates the Motility of Bidirectional Cargoes via Motor Persistence"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Engineering Inhibitable Kinesin-2 Motors to Study Ciliary Trafficking"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Probing the Mechanics of Micron-Scale Microtubule Networks"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"A Computational Model of Motor-Microtubule Self-Organization: Two Critical Parameters Drive Polar Versus Nematic Network Formation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Microtubule Mechanics and Turnover"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Motors in Cancer Discussion Leader:
7:30 pm - 7:50 pm	"Genome Damage from Cytoskeletal Contractile Forces"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Where the K-Fiber Ends: The Importance of Kif18A Neck Linker Length for Mitotic Localization"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Total Inhibition of Mitotic Spindle Assembly in Animal Cells"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Basal Extrusion of KRas-Transformed Cells Drives Invasion and Loss of Epithelial Identity"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Harnessing the Adaptive Potential of Mechanoresponsive Proteins to Overwhelm Pancreatic Cancer Dissemination and Invasion"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Motors in Neurological Function and Disease Discussion Leader:
9:00 am - 9:20 am	"Motors in Neurons: Express Shipping and Localized Delivery"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Sorting out Polarized Transport in Neurons"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Putting the Brakes on Motor Activity During Polarized Transport in Neurons"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Myosin 18A Targets a Rac GEF to Regulate Dendritic Spine Morphology"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Regulation and Function of Retrograde Mitochondrial Transport"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"TUBB3 in Health and Disease"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Biogenesis of Prion Protein Aggregates in Axons Involve Molecular Motor-Dependent Secretory and Endocytic Pathways"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Late-Breaking Topics in in Cytoskeletal Research Discussion Leader:
7:30 pm - 7:50 pm	"Ciliary Assembly and Intraflagellar Transport"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Focal Accumulations of Tau Protein Differentially Regulate Dynein-Driven Motility"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Synthetic-Evolution Approach to Study the Plasticity of Phospho-Regulation of the Mitotic Kinesin-5 Cin8"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Microtubule Structural State Recognition by the End-Binding Protein EB1"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Mechanisms of Myosin VI Functional Diversity at Membrane-Bound Organelles"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Myo10 Drives Filopodia of Mammalian Myoblasts to Promote Cell Fusion and Muscle Regeneration Following Injury"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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