Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Motors Working in a Context
Discussion Leader: Margaret Titus (University of Minnesota, USA)
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7:40 pm - 8:15 pm |
Vladimir Gelfand (Northwestern University, USA)
"Microtubule Motors and Cell Polarity: Lessons from Neurons and Oocytes"
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8:15 pm - 8:30 pm |
Discussion
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8:30 pm - 9:05 pm |
Kathleen Trybus (University of Vermont, USA)
"Something for Everyone: Two Vignettes Featuring Myosin, Kinesin, Dynein And Their Tracks"
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9:05 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Motors in Cardiovascular Disease
Discussion Leader: David Warshaw (University of Vermont College of Medicine, USA)
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9:00 am - 9:20 am |
Anne Houdusse (Institut Curie / CNRS, France)
"Allosteric Tuning of Myosin Force Generation: New Avenues to New Therapies"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
James Spudich (Stanford University School of Medicine, USA)
"The Myosin Mesa and Hypertrophic Cardiomyopathy: Mutations to Mechanisms to Therapies"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Theresia Kraft (Hannover Medical School, Germany)
"Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles Leading To Cell-To-Cell Contractile Imbalance As Possible Trigger For Hypertrophic Cardiomyopathy"
|
10:50 am - 11:00 am |
Discussion
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11:00 am - 11:20 am |
Sanford Bernstein (San Diego State University, USA)
"Integrative Analysis of Myosin-Based Cardiomyopathies"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:45 am |
Short Talk Selected from Poster Abstracts
|
11:45 am - 11:50 am |
Discussion
|
11:50 am - 12:05 pm |
Short Talk Selected from Poster Abstracts
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Margaret Titus (University of Minnesota, USA)
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Structure and Regulation
Discussion Leader: Carolyn Moores (University of London, United Kingdom)
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7:30 pm - 7:50 pm |
Ahmet Yildiz (University of California, Berkeley, USA)
"The Mechanism and Regulation of Mammalian Dynein/Dynactin"
|
7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Anthony Roberts (University of London, United Kingdom)
"Structure and mechanism of Dynein-2"
|
8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Hernando Sosa (Albert Einstein College of Medicine, USA)
"New Insights into The Mechano-Chemical Coordination Mechanism Of Kinesin-Microtubule Complexes From Their Near-Atomic Resolution Structures"
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8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Stefan Raunser (Max Planck Institute of Molecular Physiology, Germany)
"Structural Understanding of The Function of Actin In Muscles And In The Cytoskeleton"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Motors in Cell Motility and Transport
Discussion Leader: James Sellers (National Heart, Lung, and Blood Institute, NIH, USA)
|
9:00 am - 9:20 am |
David Warshaw (University of Vermont, USA)
"3-D Model System of Intracellular Cargo Transport"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Richard Cheney (University of North Carolina at Chapel Hill, USA)
"Cellular and Organismal Functions of Myosin X, a Filopodial Motor Protein"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Samara Reck-Peterson (University of California, San Diego, USA)
"Regulation of Cytoplasmic Dynein"
|
10:50 am - 11:00 am |
Discussion
|
11:00 am - 11:20 am |
Erika Holzbaur (University of Pennsylvania, USA)
"Actin Cycling, Myosin Tethering, and Mitochondrial Dynamics: How the Cytoskeleton Regulates Mitochondrial Health"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:45 am |
Short Talk Selected from Poster Abstracts
|
11:45 am - 11:50 am |
Discussion
|
11:50 am - 12:05 pm |
Short Talk Selected from Poster Abstracts
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Modeling and Analysis of Molecular Motor Systems
Discussion Leader: Erkan Tuzel (Temple University, USA)
|
7:30 pm - 7:50 pm |
David Odde (University of Minnesota, USA)
"Motors, Clutches, and Cell Migration"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Tamara Bidone (University of Utah , USA)
"Multiscale Models and Simulations Of The Cochlear Motor Protein Prestin"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Michael Murrell (Yale University, USA)
"Myosin Catch Bond Dynamics Determine a Solid-Fluid Transition"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Michael Diehl (Rice University, USA)
"Signaling Scaffolds as Probes Of Cytoskeletal Regulation"
|
9:20 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Motor Generated Forces in Cell Function
Discussion Leader: Sarah Heissler (Ohio State University, USA)
|
9:00 am - 9:20 am |
Michael Ostap (University of Pennsylvania, USA)
"Mechanisms of Force Sensing By Cytoskeletal Motors"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Ewa Paluch (University of Cambridge, United Kingdom)
"Cell Mechanics Across Scales: Molecular Control of Cortical Tension Generation"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Andre Levchenko (Yale University, USA)
"Control Of Myosin-Driven Motility In 3D Cell Migration"
|
10:50 am - 11:00 am |
Discussion
|
11:00 am - 11:20 am |
Jordan Beach (Loyola University Stritch School of Medicine, USA)
"It's a Trap! Mechanisms of Non-Muscle Myosin II Assembly"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:45 am |
Short Talk Selected from Poster Abstracts
|
11:45 am - 11:50 am |
Discussion
|
11:50 am - 12:05 pm |
Short Talk Selected from Poster Abstracts
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Tracks and Filaments
Discussion Leader: Antonina Roll-Mecak (NIH, USA)
|
7:30 pm - 7:50 pm |
Anna Kashina (University of Pennsylvania, USA)
"Distinct Roles for Nucleotides and Amino Acids In Defining Actin's Biological Function”"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Enrique De La Cruz (Yale University, USA)
"Actin Network Disassembly"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Jennifer Ross (Syracuse University, USA)
"Remodeling Microtubule Networks with Motors and Cross Linkers"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Casper Hoogenraad (Genentech, USA)
"Mechanisms of Neuronal Polarity: Microtubule Remodeling and Cargo Sorting"
|
9:20 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Motors in Cancer, Psychiatric, Metabolic, and Infectious Diseases
Discussion Leader: Lee Sweeney (University of Florida, USA)
|
9:00 am - 9:20 am |
Anne Bresnick (Albert Einstein College of Medicine, USA)
"Myosin Regulatory Proteins in Invasion"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Jonathan Kirk (Loyola University Chicago Stritch School of Medicine, USA)
"Functional Impact of Myofilament Glycation in Cardiovascular Disease"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:30 am |
Coffee Break
|
10:30 am - 10:50 am |
Dominique Soldati-Favre (University of Geneva, Switzerland)
"The Conoid: an Enigmatic and Dynamic Organelle that Serves as Actin Polymerization Platform for Motility in Apicomplexa"
|
10:50 am - 11:00 am |
Discussion
|
11:00 am - 11:20 am |
Michael Way (Francis Crick Institute, United Kingdom)
"Reconstituting Microtubule-Based Motility of Vaccinia Virus In Vitro"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Courtney Miller (The Scripps Research Institute, USA)
"Therapeutic Development of Clinically Safe Nonmuscle Myosin II Inhibitors"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Short Talk Selected from Poster Abstracts
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Motors in Mitosis
Discussion Leader: Jason Stumpff (University of Vermont, USA)
|
7:30 pm - 7:50 pm |
Ekaterina Grishchuk (University of Pennsylvania, USA)
"A Microtubule Depolymerization Motor for Chromosome Motion"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Tarun Kapoor (The Rockefeller University, USA)
"Structural Insights into The Chemical Inhibition of Dynein"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Sophie Dumont (University of California, San Francisco, USA)
"Opposing Active Forces Provide Mechanical and Functional Robustness in The Mammalian Spindle"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
William Bement (University of Wisconsin-Madison, USA)
"Unconventional Roles for Myosins In Cell Division"
|
9:20 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|