Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Genetics and Epigenetics of Cancer
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
"Targeting Replicative Stress in Cyclin E-Amplified Tumors"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Disentangling Genetic and Epigenetic Interplay in Medulloblastoma"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Germline DNA Repair Mutations in Cancer Patients"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer-Associated DNA Damage and Mutation
9:00 am - 9:20 am
"APOBEC Mutagenesis, Viral Infection and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms Underlying Mutation Load and Mutation Signatures"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Damage Is a Major Cause of Sequencing Errors, Confounding the Identification of Somatic Mutations in Tumor Samples"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Signatures of Complex and Noncoding Variants in Cancer Whole Genome Sequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Impact of Human Papillomavirus Integration and DNA Damage in Cervical Carcinogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Cancer Heterogeneity: From DNA Mutability to Protein Dysfunction"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Foundations of DNA Damage, Mutation and Cancer
7:30 pm - 8:05 pm
"Fifty Years of DNA Repair: From Finding Nth to Finding How Nth Finds Damage"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Genome Sequencing to Understand Tumorigenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"A p53-Independent DNA Damage Response Suppresses Oncogene-Induced Proliferation and Genomic Instability"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Etiology of Mutations in Cancer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cancer and DNA Repair Pathways
9:00 am - 9:20 am
"Dissecting the Functions of BRCA1"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cellular Repair of DNA-Protein Cross-Links Induced by Antitumor Drugs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Functional Consequences of DNA Repair Gene Mutations in Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Whole Genome Characterization of Germline Chromosomal Rearrangements Reveals Underlying Disease Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"shRNA Screen Targeting the DDRome Identifies Synthetic Lethal Interactions with Chk1 Inhibitor"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"A Genome-Wide Assay of DNA Repair Capacity"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Treatments Based on DNA Repair
7:30 pm - 7:50 pm
"BRCA1 Mutations and Mechanisms of PARP Inhibitor Resistance"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Preclinical Antitumor Activity of Niraparib and Its Combination with Anti-Pd-1 Therapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Targeting DNA Damage Responses for the Treatment of Lung Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Liver-Kidney Organs-on-a-Chip Reveal Distant Site for Bioactivation of Aristolochic Acid"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Roles of DNA Polymerase Kappa in Subverting Replication Stress in Cancer Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Resistance to Platinum-Based Drugs Requires Multiple DNA Repair Pathways"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Crystal Structure Analysis of Cancer-Associated Mutations in DNA Repair Enzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"MUTYH Glycosylase Variants Associated with Colorectal Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Molecular Mechanism of Eukaryotic Transcription-Coupled Repair Initiation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"DNA Damage Signaling to Immune Checkpoints"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The BRCA-FA Pathway and the Replication Stress Response"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer Evolution"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Visualizing Replication Fork Repair Dynamics in Cells"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mutation and Cancer: New Insights from Model Systems
9:00 am - 9:20 am
"Promises and Challenges for Checkpoint Inhibitors as Anti-Cancer Drugs"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Insights into Mechanisms of PARP Inhibitor Resistance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Polymerase Epsilon Mutations in Cancers"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mutation and Genome Instability Events from Ribonucleotides in DNA"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Therapeutic Alkylating Agents and the Role of Rad51 Paralogs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Acute Dependence of Cancer Cells on Base Excision Repair Auxiliary Factors"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mutations Facilitated by DNA Damage and Structure
7:30 pm - 7:50 pm
"Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in Mice Lacking UNG and SMUG1"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"MUTL Structures and Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"DNA Structure, Mutation, and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Specialized DNA Polymerases and Replication of Heterochromatin in the Genome"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure