Understanding DNA Damage Responses to Target Cancer

February 29 - March 1, 2020

Chairs Judit Jimenez Sainz and Ryan Barnes

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, CA, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on DNA Damage, Mutation and Cancer is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. This meeting will foster collaboration, networking and community building.

The focus of this meeting is on DNA damage responses, mutagenesis processes, genetic and genomic alterations, cancer mechanisms and targeted therapy. The keynote speaker is Aishwarya Prakash (PhD, University of South Alabama Mitchell Cancer Institute). The mentoring component will promote networking and scientific discussion. It will also support career independence and diversity.

Related Meeting

This GRS will be held in conjunction with the "DNA Damage, Mutation and Cancer" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Structural Insights into Protein Interactions Discussion Leaders: Rebecca Bilardi (The Walter and Eliza Hall Institute, Australia) and Karl Zahn (Howard Hughes Medical Institute / Yale University, USA)
3:45 pm - 4:20 pm	Aishwarya Prakash (The University of South Alabama, USA) "Structural Insights into Protein Interactions"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	DNA Repair, Replication and Pathway Choice Discussion Leaders: Niraj Joshi (Dana-Farber Cancer Institute / Harvard Medical School, USA) and Emily Schleicher (Penn State College of Medicine, USA)
7:30 pm - 7:45 pm	Annie Demin (Genome Damage and Stability Centre, University of Sussex, United Kingdom) "XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Qi Liu (Shenzhen Bay Laboratory, China) "TGFβ Signaling Suppresses Alternative End Joining Gene Expression"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Ciara McKnight (University of Mississippi Medical Center, USA) "The Role of H1 Linker Histones in the DNA Damage Repair Pathways "
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Lili Blumenberg (New York University School of Medicine, USA) "Data-Driven Discovery of Phosphorylation Modules in Cancer "
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Yusuke Kojima (Mayo Clinic, USA) "FAM111A Protects Replication Forks from Protein Obstacles via Its Trypsin-Like Domain"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Sumeet Nayak (University of Massachusetts Medical School, USA) "Replication Gaps Are a Cancer Vulnerability Counteracted by Translesion Synthesis (TLS)"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Unstable Loci and Cancer Therapies Discussion Leaders: John Krais (Fox Chase Cancer Center, USA) and Tajinder Ubhi (University of Toronto, Canada)
9:00 am - 9:15 am	Anastasia Rastokina (Tufts University, USA) "Understanding the Mechanism Behind GAA Repeat Expansions Using Mammalian Cells"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	David Pladevall-Morera (Center for Chromosome Stability, University of Copenhagen, Denmark) "Proteomic Characterization of Chromosomal Common Fragile Site (CFS)-Associated Proteins Uncovers ATRX as a Regulator of CFS Stability"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Daniela Muoio (Thomas Jefferson University, USA) "Towards Distinct Roles of PARP1 and PARP2 Enzymes in the Preservation of Telomere Integrity"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Michael Sharp (St. Vincent's Institute of Medical Research, Australia) "Targeting BRCA1/2 Cancers by Inhibiting the Fanconi Anemia Core Complex with Small Molecules"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Elena Demidova (Fox Chase Cancer Center, USA) "Functional Evaluation of Novel DNA Polymerase Variants in Patients with Early-Onset Renal Cancer"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Lloyd Smyth (University of Melbourne, Australia) "X-Ray Microbeams Elicit a More Prolonged Immune and Inflammatory Response in the Brainstem than Homogenous Irradiation"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: How to Navigate the Transition to Independence Discussion Leaders: Carlos Mendez-Dorantes (City of Hope, USA) and Shanaya Shah (University of California, Davis, USA)
1:30 pm - 2:30 pm	Panel Discussion How to Navigate the Transition to Independence Tiago Faial (Nature Genetics, USA) Anthony Forget (Intellia Therapeutics, USA) Hannah Klein (New York University School of Medicine, USA) Aishwarya Prakash (The University of South Alabama, USA) Jeremy Stark (City of Hope, USA)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA250271. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History DNA Damage, Mutation and Cancer

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DNA Damage, Mutation and Cancer

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