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Saturday
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| 2:00 pm - 5:00 pm |
Arrival and Check-in
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| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:45 pm - 4:30 pm |
Keynote Session: Structural Insights into Protein Interactions
Discussion Leaders: Rebecca Bilardi (The Walter and Eliza Hall Institute, Australia) and Karl Zahn (Howard Hughes Medical Institute / Yale University, USA)
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| 3:45 pm - 4:20 pm |
Aishwarya Prakash (The University of South Alabama, USA)
"Structural Insights into Protein Interactions"
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| 4:20 pm - 4:30 pm |
Discussion
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| 4:30 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
DNA Repair, Replication and Pathway Choice
Discussion Leaders: Niraj Joshi (Dana-Farber Cancer Institute / Harvard Medical School, USA) and Emily Schleicher (Penn State College of Medicine, USA)
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| 7:30 pm - 7:45 pm |
Annie Demin (Genome Damage and Stability Centre, University of Sussex, United Kingdom)
"XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair"
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| 7:45 pm - 7:50 pm |
Discussion
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| 7:50 pm - 8:05 pm |
Qi Liu (Shenzhen Bay Laboratory, China)
"TGFβ Signaling Suppresses Alternative End Joining Gene Expression"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Ciara McKnight (University of Mississippi Medical Center, USA)
"The Role of H1 Linker Histones in the DNA Damage Repair Pathways "
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Lili Blumenberg (New York University School of Medicine, USA)
"Data-Driven Discovery of Phosphorylation Modules in Cancer "
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Yusuke Kojima (Mayo Clinic, USA)
"FAM111A Protects Replication Forks from Protein Obstacles via Its Trypsin-Like Domain"
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| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:25 pm |
Sumeet Nayak (University of Massachusetts Medical School, USA)
"Replication Gaps Are a Cancer Vulnerability Counteracted by Translesion Synthesis (TLS)"
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| 9:25 pm - 9:30 pm |
Discussion
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
Unstable Loci and Cancer Therapies
Discussion Leaders: John Krais (Fox Chase Cancer Center, USA) and Tajinder Ubhi (University of Toronto, Canada)
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| 9:00 am - 9:15 am |
Anastasia Rastokina (Tufts University, USA)
"Understanding the Mechanism Behind GAA Repeat Expansions Using Mammalian Cells"
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| 9:15 am - 9:20 am |
Discussion
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| 9:20 am - 9:35 am |
David Pladevall-Morera (Center for Chromosome Stability, University of Copenhagen, Denmark)
"Proteomic Characterization of Chromosomal Common Fragile Site (CFS)-Associated Proteins Uncovers ATRX as a Regulator of CFS Stability"
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| 9:35 am - 9:40 am |
Discussion
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| 9:40 am - 9:55 am |
Daniela Muoio (Thomas Jefferson University, USA)
"Towards Distinct Roles of PARP1 and PARP2 Enzymes in the Preservation of Telomere Integrity"
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| 9:55 am - 10:00 am |
Discussion
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| 10:00 am - 10:15 am |
Michael Sharp (St. Vincent's Institute of Medical Research, Australia)
"Targeting BRCA1/2 Cancers by Inhibiting the Fanconi Anemia Core Complex with Small Molecules"
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| 10:15 am - 10:20 am |
Discussion
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| 10:20 am - 10:35 am |
Elena Demidova (Fox Chase Cancer Center, USA)
"Functional Evaluation of Novel DNA Polymerase Variants in Patients with Early-Onset Renal Cancer"
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| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 10:55 am |
Lloyd Smyth (University of Melbourne, Australia)
"X-Ray Microbeams Elicit a More Prolonged Immune and Inflammatory Response in the Brainstem than Homogenous Irradiation"
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| 10:55 am - 11:00 am |
Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: How to Navigate the Transition to Independence
Discussion Leaders: Carlos Mendez-Dorantes (City of Hope, USA) and Shanaya Shah (University of California, Davis, USA)
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| 1:30 pm - 2:30 pm |
Panel Discussion
How to Navigate the Transition to Independence
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Tiago Faial (Nature Genetics, USA)
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Anthony Forget (Intellia Therapeutics, USA)
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Hannah Klein (New York University School of Medicine, USA)
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Aishwarya Prakash (The University of South Alabama, USA)
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Jeremy Stark (City of Hope, USA)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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