Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Bridging Modern Technologies with Foundational DMPK Principles to Develop Improved Therapeutics
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Biochemistry to Organic Chemistry in Drug Metabolism"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges and Solutions for Characterization of Non-CYP Mediated Metabolic Pathways
9:00 am - 9:30 am
"Differential WIN18,446-Induced Inhibition of Human ALDH1A1 and ALDH1A2"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Unveiling the Role of Hydrolases in Drug Development and Precision Pharmacotherapy"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Targeting GSTs in Lung Injury"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Optimization of Metabolism in Macrocyclic Peptide Drug Discovery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Understanding the Regulation and Expression of Drug Metabolizing Enzymes
7:30 pm - 7:55 pm
"Atypical Regulation of CYP1B1 in Hepatic Stellate Cell Activation and Liver Fibrosis"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Lost in Translation: Interpreting Enzyme Down-Regulation in Induction Testing with Human Hepatocyte Culture Systems"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Inflammation-Driven Regulation of Drug Metabolizing Enzymes and its Clinical Implication"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microphysiological Systems as Models of Disease and DMPK
9:00 am - 9:30 am
"Regulatory Acceptance of Human on a Chip Systems for Efficacy, Safety and DMPK Studies"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Systemic Modeling of Human Skeletal Metastasis Using the InterOrgan Microphysiological System"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Integrating In Vitro and In Silico Models for Subcutaneous Drug Delivery and Biodistribution"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Integrating Complex In Vitro Model Contexts of Use with Fit-for-Purpose Strategies for Translational Impact"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Current Progress in Biotransformation Research and Metabolite Identification Techniques
7:30 pm - 7:55 pm
"Accelerator Mass Spectrometry for the Support of Microtracer Studies at Boehringer-Ingelheim: Insights to Technology, Applications and Strategies in State-of-the-art Drug Development"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"The Evolving Role of 19 F qNMR in Drug Metabolism Studies from Discovery Through Development"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Applications for Advanced Hepatocyte Models in Metabolite Profiling"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Harnessing the Power of Transporters to Develop Improved Therapeutics
9:00 am - 9:30 am
"The Risk and Benefits of Manipulating Tyrosine Kinase Regulation of Solute Carriers"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Expanding the Genetic Code to Study the Structure, Function and Regulation of the Human Apical Sodium-Dependent Bile Acid Transporter, ASBT"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Utility of Lysosomal Transporters as Gates for Drug Entry into the Cytoplasm"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Hepatic Uptake Transport of Oligonucleotide Drugs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Short Talks Selected from Poster Abstracts
7:30 pm - 7:45 pm
Short Talk Selected from Poster Abstracts
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Short Talk Selected from Poster Abstracts
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Challenges and Opportunities in ADME Investigations of Novel Therapeutic Modalities
9:00 am - 9:30 am
"Bridging Boundaries: A Comprehensive Look at Therapeutic Protein Biotransformation"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Intracellular Biodistribution and Biotransformation of ADC"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Replication Competent Viruses: Important Considerations for Pharmacokinetics and Biodistribution Assessment"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Non-Invasive Imaging Using the NIS Reporter Gene in Monitoring PK/PD of Virus, Gene and Cell Therapies"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DDI+: Considerations for all Ages and Stages of Drug Development and Utilization
7:30 pm - 7:55 pm
"Clinical and Drug-Drug Interaction Implications of Changes in Drug Transporter Abundance/Function in Disease"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Machine Learning Modeling of Drug DMPK Properties and DDI Predictions"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"There Is More to Pediatric DDI Than Just Ontogeny: Special Considerations for Pediatric Trial Design"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure