1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Navigating The Diverse Landscape of Drug Therapeutics
Patrick Glassman (Temple University, United States)
3:45 pm - 4:05 pm
Mark Bryniarski (Amgen, United States) "Assays And Mechanisms To Define Target Independent Clearance Of Therapeutic Antibodies"
4:05 pm - 4:10 pm
4:10 pm - 4:25 pm
Jinghan Liu (University of Michigan, United States) "Cytochrome P450 3A7 Structure Reveals Four Binding Sites For Its Native Substrate Dehydroepiandrosterone Sulfate (DHEA-S)"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Perspectives and Challenges in In vitro- In vivo ADME
Theresa Aliwarga (Amgen, United States)
7:30 pm - 7:50 pm
Patrick Glassman (Temple University, United States) "Predictive Pharmacokinetics of Drug Delivery Systems: Are We There Yet?"
7:50 pm - 7:55 pm
7:55 pm - 8:10 pm
Eva Streekstra (Radboudumc & TNO, The Netherlands) "Intestinal Tissue Organoids To Study Drug Transport And Metabolism From Infants To Adults"
8:10 pm - 8:15 pm
8:15 pm - 8:30 pm
Ankit Balhara (University of Washington, United States) "Prediction and Validation of Fetal Exposure to Dual BRPR/P-gp Drug Substrates Using the Proteomics Informed Relative Expression Factor (ER-REF) approach and PBPK modeling and Simulation"
8:30 pm - 8:35 pm
8:35 pm - 8:50 pm
Sneha Rathi (University of Minnesota, United States) "Systemic and CNS Distributional Pharmacokinetics of WSD0628, A Novel Radiosensitizer for The Treatment of Brain Tumors"
8:50 pm - 8:55 pm
8:55 pm - 9:10 pm
Sean Edwards (University of Liverpool, UK, United Kingdom) "In Silico Modelling of Transmucosal Drug Delivery Informed by In Vitro Approaches"
9:10 pm - 9:15 pm
9:15 pm - 9:25 pm
Md Tariqul Haque Tuhin (Amgen Inc., United States) "Implications of pH-Dependent Non-Specific Interactions on The Cellular Disposition of Monoclonal Antibodies"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Methods And Techniques In Addressing Challenges In Translating In vitro-In vivo ADME
Herana Kamal Seneviratne (University of Maryland, Baltimore County, United States) and Lindsay Czuba (University of Kentucky, United States)
9:00 am - 9:20 am
Lindsay Czuba (University of Kentucky, United States) "Transport Of Secondary Bile Acid Metabolites And Their Putative Role On Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis"
9:20 am - 9:25 am
9:25 am - 9:35 am
Mohammed Yousuf (Temple University, United States) "Using Net Clearances to Simulate Drug Permeation Across MDCK Cells"
9:35 am - 9:40 am
9:40 am - 9:50 am
Mattie Hartauer (University of North Carolina - Chapel Hill, United States) "Characterization of a Human Liver Organoid Model: Transport Protein Expression, Localization, Function, and Regulation"
9:50 am - 9:55 am
9:55 am - 10:15 am
Herana Kamal Seneviratne (University of Maryland, Baltimore County, United States) "Understanding Drug Metabolism, Disposition, And Response Using Mass Spectrometry Imaging"
10:15 am - 10:20 am
10:20 am - 10:35 am
Mengyue (Melody) Yin (University of Washington, United States) "Prediction And Validation Of Human Hepatobiliary Clearances And Hepatic Concentrations Of Transported Drugs, Pitavastatin, And Glyburide Using The REF And PET Imaging Approaches"
10:35 am - 10:40 am
10:40 am - 10:55 am
Wenjuan Zhang (University of Minnesota, United States) "
How Much is Enough? BI-907828: A MDM2-p53 Antagonist With Limited BBB Penetration But Potent Efficacy in Glioblastoma"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Defining A Career Path In Drug Metabolism And Pharmacokinetics Research
Annamarie Bustion (UCSF, United States)
1:30 pm - 2:30 pm
Promoting Career Growth
Diane Ramsden (AstraZeneca, United States)
Valerie Kramlinger (Vanderbilt University, United States)
Xiling Jiang (FDA, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)