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Drug Resistance

Gordon Research Conference

Looking for Common Themes and Solutions in Drug Resistance for Cancer, Infectious Disease and Agriculture

July 22 - 27, 2018

Chairs Jared A. Silverman and Juswinder Singh

Vice Chair Michael H. Cynamon

Bryant University

1150 Douglas Pike

Smithfield, RI, United States

Venue and Travel Information

Conference Description

The 2018 Gordon Research Conference on Drug Resistance will build on the success of the three prior meetings to focus on assembling a multi-disciplinary group of basic and clinical scientists to understand mechanisms of drug resistance and how to identify and to overcome them using novel strategies.

Drug resistance is a major challenge for the effectiveness of therapies in cancer and infectious diseases and for agricultural products including herbicides and pesticides. Drug resistance negatively impacts the health of millions in both developed and developing nations and has a massive financial impact on society. Despite the common issues facing these fields there are no forums that encourage cross-disciplinary interaction on this important problem. This forum will serve a unique and critical role of bringing together experts from different disciplines to create a community which will share expertise around drug resistance and work together on effective long term solutions. The community will explore areas including identifying resistance mechanisms, computational modeling of resistance from cells to humans, the use of diagnostics to identify and monitor resistance and the development of novel treatments. Beyond science, the community will become a valuable expert resource for policy makers to develop and guide implementation of effective long term strategies.

The meeting will assemble a broad group from a diverse area of disciplines including established experts, young investigators and students with wide geographic and cultural perspective to build a long term community. This will include representation from academic, biotech/pharma and government. The meeting will encourage cutting edge-research presentations coupled with significant discussions and will also provide an opportunity for students to highlight research through poster presentations with the opportunity of a select group of students to present short oral presentations.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Reviewing Progress and Setbacks on the Front Lines of Drug Resistance Discussion Leader: Juswinder Singh (Ankaa Therapeutics, USA)
7:40 pm - 8:20 pm	Vance Fowler (Duke University Medical Center, USA) "Antibacterial Resistance and the Antibacterial Resistance Leadership Group: Problems, Innovations and Productivity"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	Stephen Fawell (AstraZeneca, USA) "Challenges and Opportunities in Cancer Drug Resistance"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Modeling of Resistance Discussion Leader: Dominik Wodarz (University of California, Irvine, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	Natalia Komarova (University of California Irvine, USA) "Stochastic Modeling of Drug Resistance in Cancer"
9:35 am - 9:50 am	Discussion
9:50 am - 10:20 am	Bruce Levin (Emory University, USA) "The Within-Host Pharmaco-Population- and Immune-Dynamics of Antibiotic Treatment and the Evolution of Resistance"
10:20 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	James Korkola (Oregon Health & Science University, USA) "Imaging Approaches to Discovery of Microenvironment Mediated Resistance Mechanisms in Cancer"
11:30 am - 11:45 am	Discussion
11:45 am - 11:55 am	Alison Hill (Harvard University, USA) "Life Cycle Synchronization Is a Viral Drug Resistance Mechanism"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Justin Pritchard (The Pennsylvania State University, USA) "Nucleotide Mutation Biases Can Drive the Prevalence of Specific Amino Acid Mutations that Confer Drug Resistance"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New and Emerging Drug Resistance Mechanisms Discussion Leader: Priscilla Yang (Harvard Medical School, USA)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	Judith Berman (Tel Aviv University, Israel) "Clearing the FoG: Quantification and Characterization of Antifungal Tolerance"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Anaïs Aulas (Brigham and Women's Hospital / Harvard Medical School, USA) "Stress Granules as Potential Biomarkers for Chemotherapy Drug Resistance"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Anil Korkut (University of Texas MD Anderson Cancer Center, USA) "TargetScore: A Data-Driven Network Biology Algorithm for Overcoming Adaptive Resistance to Cancer Therapy"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Tackling Resistance in Discovery and Development for Cancer Discussion Leader: Aaron Goldman (Harvard Medical School, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	Erica Evans (Blueprint Medicines, USA) "Building Kinase Inhibitor Programs with Resistance in Mind"
9:35 am - 9:50 am	Discussion
9:50 am - 10:20 am	Sara Buhrlage (Dana-Farber Cancer Institute, USA) "Novel Strategies to Induce Degradation of Leukemia Oncogenes"
10:20 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:35 am	Trever Bivona (University of California, San Francisco, USA) "Emerging Principles of Resistance to Targeted Cancer Therapy"
11:35 am - 11:45 am	Discussion
11:45 am - 12:15 pm	Paul Mischel (San Diego Branch, Ludwig Cancer Research / University of California, San Diego, USA) "In Cancer, as in Real Estate, Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tackling Resistance in Discovery and Development for Anti-Infectives Discussion Leader: Michael Cynamon (VA Medical Center, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Tim van Opijnen (Boston College, USA) "Predicting Antibiotic Resistance Through Microfluidics, Single Cell-Analysis, Omics-Approaches, Experimental Evolution and Full-Genome Modeling"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	Paul Ambrose (Institute for Clinical Pharmacodynamics, Inc., USA) "Antimicrobial Replication Rate Modulation: Turning the Microbe Against Itself"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	Ann Kwong (Trek Therapeutics, USA) "HCV Is the Only Viral Infection that Can Be Cured – Harbinger of the Future or a Unicorn?"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	New Approaches to Drug Resistance Discussion Leader: Neil Dhawan (Fuse Therapeutics, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	John Overington (Medicines Discovery Catapult, United Kingdom) "Drug Blending as an Approach to Tackling Cancer Resistance"
9:35 am - 9:50 am	Discussion
9:50 am - 10:20 am	Jean-Marie Pagès (Aix-Marseille University, France) "Antibiotic Translocation and Membrane Barrier: New Tools to Dissect the Bacterial Resistance"
10:20 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	Cassandra Quave (Emory University, USA) "Medical Ethnobotany and the Discovery of New Drugs to Combat Antibiotic Resistance"
11:30 am - 11:45 am	Discussion
11:45 am - 11:55 am	Ignacio Rodriguez-Brenes (University of California, Irvine, USA) "Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Rebecca Yeboah (WACCBIP, University of Ghana, Ghana) "Analysis of Antimicrobial Resistance Phenotypes in Candida albicans Using Modulators of Mdr/Cdr Gene Expression"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Jens Rolff (Free University of Berlin, Germany) "Predicting Drug Resistance Evolution: Antibiotics vs. Antimicrobial Peptide"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Late-Breaking Topics Discussion Leader: Carolyn Shore (National Academies of Sciences, Engineering, and Medicine, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Jo-Anne Dillon (University of Saskatchewan, Canada) "How Neisseria gonorrhoeae Emerged as a Superbug: Are Current Strategies to Combat AMR Effective?"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Elizabeth Winzeler (University of California, San Diego, USA) "Mapping the Malaria Parasite Druggable Genome by Using In Vitro Evolution and Chemogenomics"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Shashank Gupta (Brown University, USA) "Suppressor Cell-Targeted Immunotherapy with Denileukin Diftitox, a Recombinant Toxin, Improves TB Treatment"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Daniel Charlebois (Stony Brook University, USA) "Heterogeneity in Mammalian Drug Resistance"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Shannon Coleman (University of British Columbia, Canada) "Mechanisms of Antibiotic Resistance in Pseudomonas aeruginosa Swarming Motility"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Heterogeneity Discussion Leader: Alexis Kaushansky (Center for Infectious Disease Research, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	Fred Mast (Center for Infectious Disease Research, USA) "Network Biology and Infectious Disease"
9:35 am - 9:50 am	Discussion
9:50 am - 10:20 am	Andriy Marusyk (Moffitt Cancer Center, USA) "Intra-Tumor Heterogeneity in Resistance to Targeted Cancer Therapies"
10:20 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	Daruka Mahadevan (University of Arizona Cancer Center, USA) "Anti-Evolution Therapies for Cancer"
11:30 am - 11:45 am	Discussion
11:45 am - 11:55 am	Grace Anderson (Duke University, USA) "Drug Resistant Cancers Harbor Collateral Vulnerabilities that Can Be Leveraged to Select Against Resistance"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Jianmin Gao (Boston College, USA) "Novel Phage Platforms for Developing Targeted Antibiotics"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Shuyi Ma (Center for Infectious Disease Research, USA) "Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Diagnostics Discussion Leader: Andrew Tomaras (BacterioScan Inc., USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Ellen Foxman (Yale University, USA) "Host-Response Based Testing in the Diagnosis of Airway Infections"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Shana Kelley (University of Toronto, Canada) "New Technologies for Rapid Infectious Disease Diagnosis"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Jessica Beach (Peter MacCallum Cancer Centre, Australia) "Elucidating the Role of ABCB1 Transcript Fusions in Chemoresistant Ovarian Cancer"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Akos Nyerges (Biological Research Centre, Hungarian Academy of Sciences, Hungary) "Rapid Exploration of Drug Resistance-Conferring Mutations by Targeted Mutagenesis in Pathogenic Bacteria"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Ivan de Jesus Salazar Estrada (Macquarie University, Australia) "EGFR-Targeted Chemical Proteomics for Elucidating Drug Resistance Mechanisms in Cancer"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Jus and Kumud Singh

Funding for this conference was made possible in part by 1R13AI138543-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S Government.

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