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Sunday
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| 2:00 pm - 9:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Keynote Session: Reviewing Progress and Setbacks on the Front Lines of Drug Resistance
Discussion Leader: Juswinder Singh (Ankaa Therapeutics, USA)
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| 7:40 pm - 8:20 pm |
Vance Fowler (Duke University Medical Center, USA)
"Antibacterial Resistance and the Antibacterial Resistance Leadership Group: Problems, Innovations and Productivity"
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| 8:20 pm - 8:35 pm |
Discussion
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| 8:35 pm - 9:15 pm |
Stephen Fawell (AstraZeneca, USA)
"Challenges and Opportunities in Cancer Drug Resistance"
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| 9:15 pm - 9:30 pm |
Discussion
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Monday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Modeling of Resistance
Discussion Leader: Dominik Wodarz (University of California, Irvine, USA)
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| 9:00 am - 9:05 am |
Introduction by Discussion Leader
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| 9:05 am - 9:35 am |
Natalia Komarova (University of California Irvine, USA)
"Stochastic Modeling of Drug Resistance in Cancer"
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| 9:35 am - 9:50 am |
Discussion
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| 9:50 am - 10:20 am |
Bruce Levin (Emory University, USA)
"The Within-Host Pharmaco-Population- and Immune-Dynamics of Antibiotic Treatment and the Evolution of Resistance"
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| 10:20 am - 10:35 am |
Discussion
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| 10:35 am - 11:00 am |
Coffee Break
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| 11:00 am - 11:30 am |
James Korkola (Oregon Health & Science University, USA)
"Imaging Approaches to Discovery of Microenvironment Mediated Resistance Mechanisms in Cancer"
|
| 11:30 am - 11:45 am |
Discussion
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| 11:45 am - 11:55 am |
Alison Hill (Harvard University, USA)
"Life Cycle Synchronization Is a Viral Drug Resistance Mechanism"
|
| 11:55 am - 12:00 pm |
Discussion
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| 12:00 pm - 12:10 pm |
Justin Pritchard (The Pennsylvania State University, USA)
"Nucleotide Mutation Biases Can Drive the Prevalence of Specific Amino Acid Mutations that Confer Drug Resistance"
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| 12:10 pm - 12:15 pm |
Discussion
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| 12:15 pm - 12:30 pm |
General Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
New and Emerging Drug Resistance Mechanisms
Discussion Leader: Priscilla Yang (Harvard Medical School, USA)
|
| 7:30 pm - 7:45 pm |
Introduction by Discussion Leader
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| 7:45 pm - 8:15 pm |
Judith Berman (Tel Aviv University, Israel)
"Clearing the FoG: Quantification and Characterization of Antifungal Tolerance"
|
| 8:15 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Anaïs Aulas (Brigham and Women's Hospital / Harvard Medical School, USA)
"Stress Granules as Potential Biomarkers for Chemotherapy Drug Resistance"
|
| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Anil Korkut (University of Texas MD Anderson Cancer Center, USA)
"TargetScore: A Data-Driven Network Biology Algorithm for Overcoming Adaptive Resistance to Cancer Therapy"
|
| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:30 pm |
General Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Tackling Resistance in Discovery and Development for Cancer
Discussion Leader: Aaron Goldman (Harvard Medical School, USA)
|
| 9:00 am - 9:05 am |
Introduction by Discussion Leader
|
| 9:05 am - 9:35 am |
Erica Evans (Blueprint Medicines, USA)
"Building Kinase Inhibitor Programs with Resistance in Mind"
|
| 9:35 am - 9:50 am |
Discussion
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| 9:50 am - 10:20 am |
Sara Buhrlage (Dana-Farber Cancer Institute, USA)
"Novel Strategies to Induce Degradation of Leukemia Oncogenes"
|
| 10:20 am - 10:35 am |
Discussion
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| 10:35 am - 11:05 am |
Coffee Break
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| 11:05 am - 11:35 am |
Trever Bivona (University of California, San Francisco, USA)
"Emerging Principles of Resistance to Targeted Cancer Therapy"
|
| 11:35 am - 11:45 am |
Discussion
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| 11:45 am - 12:15 pm |
Paul Mischel (San Diego Branch, Ludwig Cancer Research / University of California, San Diego, USA)
"In Cancer, as in Real Estate, Location Matters: The Role of Extrachromosomal Oncogene Amplification in Cancer"
|
| 12:15 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Tackling Resistance in Discovery and Development for Anti-Infectives
Discussion Leader: Michael Cynamon (VA Medical Center, USA)
|
| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Tim van Opijnen (Boston College, USA)
"Predicting Antibiotic Resistance Through Microfluidics, Single Cell-Analysis, Omics-Approaches, Experimental Evolution and Full-Genome Modeling"
|
| 8:00 pm - 8:15 pm |
Discussion
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| 8:15 pm - 8:40 pm |
Paul Ambrose (Institute for Clinical Pharmacodynamics, Inc., USA)
"Antimicrobial Replication Rate Modulation: Turning the Microbe Against Itself"
|
| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:15 pm |
Ann Kwong (Trek Therapeutics, USA)
"HCV Is the Only Viral Infection that Can Be Cured – Harbinger of the Future or a Unicorn?"
|
| 9:15 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 8:30 am - 9:00 am |
Group Photo
|
| 9:00 am - 12:30 pm |
New Approaches to Drug Resistance
Discussion Leader: Neil Dhawan (Fuse Therapeutics, USA)
|
| 9:00 am - 9:05 am |
Introduction by Discussion Leader
|
| 9:05 am - 9:35 am |
John Overington (Medicines Discovery Catapult, United Kingdom)
"Drug Blending as an Approach to Tackling Cancer Resistance"
|
| 9:35 am - 9:50 am |
Discussion
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| 9:50 am - 10:20 am |
Jean-Marie Pagès (Aix-Marseille University, France)
"Antibiotic Translocation and Membrane Barrier: New Tools to Dissect the Bacterial Resistance"
|
| 10:20 am - 10:35 am |
Discussion
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| 10:35 am - 11:00 am |
Coffee Break
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| 11:00 am - 11:30 am |
Cassandra Quave (Emory University, USA)
"Medical Ethnobotany and the Discovery of New Drugs to Combat Antibiotic Resistance"
|
| 11:30 am - 11:45 am |
Discussion
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| 11:45 am - 11:55 am |
Ignacio Rodriguez-Brenes (University of California, Irvine, USA)
"Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy"
|
| 11:55 am - 12:00 pm |
Discussion
|
| 12:00 pm - 12:10 pm |
Rebecca Yeboah (WACCBIP, University of Ghana, Ghana)
"Analysis of Antimicrobial Resistance Phenotypes in Candida albicans Using Modulators of Mdr/Cdr Gene Expression"
|
| 12:10 pm - 12:15 pm |
Discussion
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| 12:15 pm - 12:25 pm |
Jens Rolff (Free University of Berlin, Germany)
"Predicting Drug Resistance Evolution: Antibiotics vs. Antimicrobial Peptide"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Late-Breaking Topics
Discussion Leader: Carolyn Shore (National Academies of Sciences, Engineering, and Medicine, USA)
|
| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Jo-Anne Dillon (University of Saskatchewan, Canada)
"How Neisseria gonorrhoeae Emerged as a Superbug: Are Current Strategies to Combat AMR Effective?"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:35 pm |
Elizabeth Winzeler (University of California, San Diego, USA)
"Mapping the Malaria Parasite Druggable Genome by Using In Vitro Evolution and Chemogenomics"
|
| 8:35 pm - 8:45 pm |
Discussion
|
| 8:45 pm - 8:55 pm |
Shashank Gupta (Brown University, USA)
"Suppressor Cell-Targeted Immunotherapy with Denileukin Diftitox, a Recombinant Toxin, Improves TB Treatment"
|
| 8:55 pm - 9:00 pm |
Discussion
|
| 9:00 pm - 9:10 pm |
Daniel Charlebois (Stony Brook University, USA)
"Heterogeneity in Mammalian Drug Resistance"
|
| 9:10 pm - 9:15 pm |
Discussion
|
| 9:15 pm - 9:25 pm |
Shannon Coleman (University of British Columbia, Canada)
"Mechanisms of Antibiotic Resistance in Pseudomonas aeruginosa Swarming Motility"
|
| 9:25 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am - 12:30 pm |
Heterogeneity
Discussion Leader: Alexis Kaushansky (Center for Infectious Disease Research, USA)
|
| 9:00 am - 9:05 am |
Introduction by Discussion Leader
|
| 9:05 am - 9:35 am |
Fred Mast (Center for Infectious Disease Research, USA)
"Network Biology and Infectious Disease"
|
| 9:35 am - 9:50 am |
Discussion
|
| 9:50 am - 10:20 am |
Andriy Marusyk (Moffitt Cancer Center, USA)
"Intra-Tumor Heterogeneity in Resistance to Targeted Cancer Therapies"
|
| 10:20 am - 10:35 am |
Discussion
|
| 10:35 am - 11:00 am |
Coffee Break
|
| 11:00 am - 11:30 am |
Daruka Mahadevan (University of Arizona Cancer Center, USA)
"Anti-Evolution Therapies for Cancer"
|
| 11:30 am - 11:45 am |
Discussion
|
| 11:45 am - 11:55 am |
Grace Anderson (Duke University, USA)
"Drug Resistant Cancers Harbor Collateral Vulnerabilities that Can Be Leveraged to Select Against Resistance"
|
| 11:55 am - 12:00 pm |
Discussion
|
| 12:00 pm - 12:10 pm |
Jianmin Gao (Boston College, USA)
"Novel Phage Platforms for Developing Targeted Antibiotics"
|
| 12:10 pm - 12:15 pm |
Discussion
|
| 12:15 pm - 12:25 pm |
Shuyi Ma (Center for Infectious Disease Research, USA)
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Diagnostics
Discussion Leader: Andrew Tomaras (BacterioScan Inc., USA)
|
| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Ellen Foxman (Yale University, USA)
"Host-Response Based Testing in the Diagnosis of Airway Infections"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:35 pm |
Shana Kelley (University of Toronto, Canada)
"New Technologies for Rapid Infectious Disease Diagnosis"
|
| 8:35 pm - 8:45 pm |
Discussion
|
| 8:45 pm - 8:55 pm |
Jessica Beach (Peter MacCallum Cancer Centre, Australia)
"Elucidating the Role of ABCB1 Transcript Fusions in Chemoresistant Ovarian Cancer"
|
| 8:55 pm - 9:00 pm |
Discussion
|
| 9:00 pm - 9:10 pm |
Akos Nyerges (Biological Research Centre, Hungarian Academy of Sciences, Hungary)
"Rapid Exploration of Drug Resistance-Conferring Mutations by Targeted Mutagenesis in Pathogenic Bacteria"
|
| 9:10 pm - 9:15 pm |
Discussion
|
| 9:15 pm - 9:25 pm |
Ivan de Jesus Salazar Estrada (Macquarie University, Australia)
"EGFR-Targeted Chemical Proteomics for Elucidating Drug Resistance Mechanisms in Cancer"
|
| 9:25 pm - 9:30 pm |
Discussion
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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