Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Evolved Drug Resistance
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
"Predicting Antibiotic Resistance"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Temporally Resolved Kinase Regulatory Networks Control Endothelial Barrier Integrity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Investigating Influenza A Matrix (M1) Protein Hyper-Stabilizers as Novel Viral Inhibitors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Rethinking Economic Incentives for the Development of Infectious Disease Drugs (IDDs) Responsive to Emerging Resistance"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bet-Hedging Strategies in Drug Tolerance and Resistance
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Whac-A-Mole: Drug Treatment Principles for Tuberculosis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"The Diversity and Evolution of Intrinsic and Acquired Antifungal Drug Tolerance"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Tradeoffs in Bacterial Physiology Determine the Efficiency of Antibiotic Killing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Apoptotic Priming: An Evolutionary Adaptation Driving Acquired Drug Resistance"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Navigating Destiny- Unraveling Fate Priming Mechanisms in Cancer Persister Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Tracking Decision-Making Strategies to Distinct Therapy Exposures in Single Cancer Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Nutrient Stimulation Sensitizes Quiescent Staphylococcus Aureus to Fluoroquinolones through the Generation of Reactive Oxygen Species"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Aneuploidy as a Determinant of the Sensitivity (or Resistance) to Anti-Cancer Treatments"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Evolutionary Medicine: Are We Losing The Fight Against Malaria?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Antimicrobial Peptide Combinations Hinder the Evolution of Bacterial Resistance"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Bacterial Adaptation to Non-Antibiotics Can Lead to Broad Antibiotic Resistance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Most Azole Antifungal Resistance Mutations in the Drug Target Provide Cross-Resistance and Carry No Fitness Cost"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Drug Resistance
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"The Gut Microbiota Modulate Clinical Responses to Statins"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Drug-Microbiome Interactions and Their Consequences on the Host"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Development of a High-Throughput Screening Platform for the Discovery of RNA-Based Antisense Antibiotics to Combat Antimicrobial Resistance"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Non-Canonical Survival Strategies of Bacteria Under Antibiotic Treatment in the Mammalian Gastrointestinal Tract"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Human Gut Commensals Evolve Towards Antibiotic Resistance Following a Course of Antibiotics"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Gut-Barrier Repair as an Alternative to Antimalarials and Antibiotics for Mitigating Malaria Severity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Artificial Intellegence in Drug Resistance
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Regulation of Drug Adaptation in Mycobacterium Tuberculosis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Bioenergetic Stresse in Antimicrobial Resistance and Persistence"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Harnessing Synthetic Lethality to Combat Drug Resistance in Malaria"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Accessing New Antibacterial Targets and Modalities through Integrated Chemistry and Genetics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Surveillance and Detection of Drug Resistance
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Resisting Resistance: Molecular Diagnostics for Herbicide Resistance in European Agriculture Weeds"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"On Life Support -- Exploring Persisters in M. Tuberculosis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Capturing the Dynamic Nature of Resistance Gene Amplifications in a Heteroresistant Population of E. Coli"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Predicting Mutations of Concern in a Pathogen Using Ab Initio Quantum Mechanical Modeling: SARS-CoV-2 as a Case Study"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Comprehensive Analyses of Drug Resistance Mutations in Mpro from SARS-CoV-2 Elucidate Interplay Between Enzyme Activity and Drug Binding"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Structure Characterization of Potent Metallo Beta Lactamase Inhibitor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Pre-Resistance Variants in Mycobacterium Spp. Arise Rapidly Following Drug Treatment and Potentiate the Emergence of Antibiotic Resistance"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tackling Resistance in Neuroscience
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Stratifying Patients to Tackle Treatment Resistant Depression"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Treatment Resistance in Epilepsy and Neuropsychological Disorders"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Blood Brain Barrier Model in Vitro for the Studies of Vascular Inflammation and Drug Responses"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
New Strategies to Overcome Resistance
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Quasispecies-Mediated Suppression of Antiviral Resistance"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Understanding the Evolution of Antibiotic Resistance Using Bacterial Single-Cell Transcriptomics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"“Self-Driving” Evolution: Steering Microbial Evolution with Reinforcement Learning"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Exploiting Synthetic Lethal Strategies to Target Virus Infected Cells"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Developing a Nanobody Repertoire for Pandemic Preparedness"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Employing Siderophore Antimicrobial Peptides to Target Drug-Resistant Enteric Bacteria in Vivo Using Live Engineered Probiotics"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Leveraging Iron Uptake to Potentiate Antibiotic Efficacy: The Role of fptA in Cefiderocol Sensitization"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Viral Drug Resistance
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:25 pm
"Lessons from Viral Proteases: From HIV to SARS-CoV-2"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Discovery of a Novel Class of Antivirals: Single-Dose, ‘Drive’ Therapies With a High Barrier to Resistance"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure