Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Elastin Properties and Assembly
Discussion Leaders: Katherine Zhang (Boston University, United States) and Robert Mecham (Washington University School of Medicine, United States)
7:40 pm - 8:00 pm
Brigida Bochicchio (University of Basilicata, Italy)
"Extracellular Matrix-Mimetic Fibers: Electrospun Bioconjugates Inspired by Elastin and Hyaluronic Acid"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Christian Schmelzer (Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Germany)
"Cross Linking of Elastin During Elastogenesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Anna Tarakanova (University of Connecticut, United States)
"Critical Steps in Elastic Fiber Assembly"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Elastin Degradation by Disease Processes
Discussion Leaders: James Pirruccello (Massachusetts General Hospital, United States)
9:00 am - 9:20 am
Scott LeMaire (Baylor College of Medicine, United States)
"Dynamic Changes Involving Elastic Fiber Genes in Thoracic Aortic Aneurysm and Dissection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
George Tellides (Yale University, United States)
"The Degradative SMC Phenotype Driven by mTOR Signaling in Thoracic Aortic Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Hiromi Yanagisawa (University of Tsukuba, Japan)
"Role of Macrophages in Maintaining and Disrupting the Aortic Wall"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Suneel Apte (Cleveland Clinic, United States)
"Role of Proteases in the Aorta"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Bhama Ramkhelawon (New York University Langone Medical Center, United States)
"Input into Late Breaking Topic place holder"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Hiromi Yanagisawa (University of Tsukuba, Japan), Ying Shen (Baylor College of Medicine, United States) and Jessica Wagenseil (Washington University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural Roles of Elastin and Microfibril Associated Proteins
Discussion Leaders: Hiromi Yanagisawa (University of Tsukuba, Japan) and Dieter Reinhardt (McGill University, Canada)
7:30 pm - 7:50 pm
Robert Mecham (Washington University School of Medicine, United States)
"Elastic Fiber Ultrastructure and Assembly"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Gerhard Sengle (University of Cologne, Germany)
"Fibrillin-1 Deficiency Impacts the Structural Integrity of Collagen - New Molecular Insight on How to Prevent Aneurysm Formation in Marfan Mice"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Clair Baldock (University of Manchester, United Kingdom)
"ADAMTS6 Mediated TGFß Activation via LTBPs"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling in Elastin Rich Tissues
Discussion Leaders: Mary Sheppard (University of Kentucky, United States) and George Tellides (Yale University, United States)
9:00 am - 9:20 am
Elena Gallo MacFarlane (Johns Hopkins University School of Medicine, United States)
"Temporal and Regional Determinants of Hereditary Aneurysm Pathogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Zhen Zhou (University of Texas Health Science Center at Houston, United States)
"Mechano-Sensing Pathways in the Progression to Aortic Dissection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Juan Miguel Redondo (Centro Nacional de Investigaciones Cardiovasculares, Spain)
"Proteoglycan Signaling Mediates Nos2 Induction and Aortic Disease in Marfan Syndrome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Dichek (University of Washington, United States)
"Time Dependent Role of TGFß Signaling in Thoracic Aortic Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Silvia Smaldone (Regeneron Pharmaceuticals, Inc., United States)
"Targeting Aortic Aneurysms in a Marfan Mouse Model"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Elastin and Microfibril Modifiers, Assembly, and Development
Discussion Leaders: Katja Schenke-Layland (NMI Natural and Medical Sciences Institute at the University Tübingen, Germany) and Anthony (Tony) Weiss (The University of Sydney, Australia)
7:30 pm - 7:55 pm
Dirk Hubmacher (Icahn School of Medicine at Mount Sinai, United States)
"Role of ADAMTS and ADAMTS-like Proteins in Musculoskeletal Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Dieter Reinhardt (McGill University, Canada)
"Fibrillin-1 Regulation of Cell Signaling and MicroRNAs"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Daniel Greif (Yale University School of Medicine, United States)
"Aortic SMC Clonal Expansion During Development and With Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Elastin and Microfibril Matrix: Multi-Omics Approaches
Discussion Leaders: Ying Shen (Baylor College of Medicine, United States) and David Dichek (University of Washington, United States)
9:00 am - 9:20 am
James Pirruccello (Massachusetts General Hospital, United States)
"Applying to Computational Methods to Large Datasets to Identify and Characterize Thoracic Aortic Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sara Procknow (Washington University in St. Louis, United States)
"Multiomics Analyses of Elastin Deficient Aortas"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Scott Damrauer (University of Pennsylvania, United States)
"Genome Wide Association Studies for Thoracic Aortic Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Daniel Goldstein (University of Michigan, United States)
"Proteomic Changes in the Aorta With Age"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Bart Spronck (Maastricht University, The Netherlands)
"Biomechanical Models of Vascular Integrity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aortic Structure and Biomechanics in Health and Disease
Discussion Leaders: Julie Phillippi (University of Pittsburgh, United States) and Bart Spronck (Maastricht University, The Netherlands)
7:30 pm - 7:50 pm
Jay Humphrey (Yale University, United States)
"Biomechanical Roles of Compromised Elastic Fiber Integrity in Aortopathy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
David Vorp (University of Pittsburgh, United States)
"Computation Modeling of Aortic Biomechanics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Shaine Morris (Baylor College of Medicine, United States)
"Arterial and Aortic Tortuosity as a Biomarker of Aortic Outcomes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Elastic Fibers in Tissue Engineering and Regenerative Medicine
Discussion Leaders: Alan Daugherty (University of Kentucky, United States) and Clair Baldock (University of Manchester, United Kingdom)
9:00 am - 9:20 am
Katja Schenke-Layland (NMI Natural and Medical Sciences Institute at the University Tübingen, Germany)
"Role of Extracellular Matrix in Biomechanics and its Impact on Bioengineering of Cells and 3D Tissues"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anthony (Tony) Weiss (The University of Sydney, Australia)
"Fabricating Organized Elastin in Vascular Grafts"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Sanjay Sinha (University of Cambridge, United Kingdom)
"Modelling Aortopathies Using Human iPS Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Naren Vyavahare (Clemson University, United States)
"In situ Elastic Fiber Regeneration to Reverse Cardiopulmonary Disease Conditions by Targeted Nanoparticle Based Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Bo Yang (University of Michigan - Michigan Medicine, United States)
"Engineering Arteries with IPSC Derived Smooth Muscle Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Elastin Structural Integrity with Aging and Environmental Damage
Discussion Leaders: Anna Tarakanova (University of Connecticut, United States) and Carmen Halabi (Washington University School of Medicine, United States)
7:30 pm - 7:50 pm
Jessica Wagenseil (Washington University, United States)
"Elastin Haploinsufficiency Has Divergent Effects Based on Sex"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Andrea Heinz (University of Copenhagen, Denmark)
"Elastin and Elastokines in Health and Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Monzur Murshed (McGill University, Canada)
"Elastin Calcification Prevention by Matrix Gla Protein"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure