Saturday
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1:30 pm - 4:30 pm |
Arrival and Check-in
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3:00 pm - 3:15 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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3:15 pm - 4:00 pm |
Metabolic Control of Endothelial Cell Function
Discussion Leaders: Ellie Karampini (Sanquin, The Netherlands) and Benjamin Thomson (Northwestern University, USA)
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3:15 pm - 3:30 pm |
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
"Metabolite Signaling in the Endothelium"
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3:30 pm - 3:35 pm |
Discussion
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3:35 pm - 3:45 pm |
Maya Chergova (University of Padova, Italy)
"The Mitochondrial Fission Factor Dynamin Related Protein 1 Limits VEGF/VEGFR2 Endocytic Trafficking and Angiogenesis"
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3:45 pm - 3:50 pm |
Discussion
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3:50 pm - 4:00 pm |
General Discussion
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4:00 pm - 5:30 pm |
Poster Session
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5:30 pm - 7:30 pm |
Signaling Pathways Regulating Endothelial Cell Behavior
Discussion Leaders: Mark Sabbagh (Johns Hopkins University School of Medicine, USA) and Thais Girão-Silva (Heart Institute, University of São Paulo Medical School, Brazil)
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5:30 pm - 5:35 pm |
Introduction by Discussion Leader
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5:35 pm - 5:50 pm |
Timothy Hla (Harvard Medical School, USA)
"Plasticity of Signaling and Gene Expression in the Endothelium"
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5:50 pm - 5:55 pm |
Discussion
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5:55 pm - 6:05 pm |
Kishor Kumar Sivaraj (Max Planck Institute for Molecular Biomedicine, Germany)
"Yap1/Taz Negatively Regulates Bone Angiogenesis and Osteogenesis"
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6:05 pm - 6:10 pm |
Discussion
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6:10 pm - 6:20 pm |
Benjamin Thomson (Northwestern University, USA)
"Dose-Dependent Effects of TEK Signaling on Schlemm's Canal Development and Function"
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6:20 pm - 6:25 pm |
Discussion
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6:25 pm - 6:35 pm |
Mirja Mewes (University Hospital Münster, Germany)
"Effects of the Soluble Adenylyl Cyclase on Endothelial Stiffness, Actin Alterations and Calcium Signals"
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6:35 pm - 6:40 pm |
Discussion
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6:40 pm - 6:50 pm |
Agnes Soos (University of Toronto, Canada)
"Shear Stress-Induced Arterial-Venous Specification of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells"
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6:50 pm - 6:55 pm |
Discussion
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6:55 pm - 7:05 pm |
Pilar Villacampa (Institut d'Investigació Biomédica de Bellvitge (IDIBELL), Spain)
"PI3-Kinase Signalling Regulates Pericyte Maturation During Angiogenesis"
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7:05 pm - 7:10 pm |
Discussion
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7:10 pm - 7:30 pm |
General Discussion
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8:00 pm - 9:00 pm |
Dinner
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Sunday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 11:00 am |
Endothelial Cell Function in the Brain / Mentorship Component: Career Development
Discussion Leaders: Kishor Kumar Sivaraj (Max Planck Institute for Molecular Biomedicine, Germany) and Nicholas Chavkin (University of Virginia, USA)
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9:00 am - 9:10 am |
Mark Sabbagh (Johns Hopkins University School of Medicine, USA)
"Transcriptional and Epigenomic Landscapes of CNS and Non-CNS Vascular Endothelial Cells"
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9:10 am - 9:15 am |
Discussion
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9:15 am - 9:25 am |
Brian Chow (Harvard Medical School, USA)
"Unraveling the Mechanism Underlying Neurovascular Coupling and Blood-Brain Barrier"
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9:25 am - 9:30 am |
Discussion
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9:30 am - 9:40 am |
Alan Tang (University of Pennsylvania, USA)
"Gut Barrier Modulation of Cerebral Cavernous Malformations"
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9:40 am - 9:45 am |
Discussion
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9:45 am - 9:55 am |
Matthias Rath (Greifswald Medical School, University of Greifswald, Germany)
"CRISPR/Cas9 Genome Editing of CCM3 in Human Endothelial Cells"
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9:55 am - 10:00 am |
Discussion
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10:00 am - 11:00 am |
Panel Discussion
Advice from Academic Investigators and Industry Professionals
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Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
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Kristy Red-Horse (Stanford University, USA)
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Timothy Hla (Harvard Medical School, USA)
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Klaus Seuwen (Novartis Institutes for Biomedical Research, Switzerland)
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Liudmila Polonchuk (Roche, Switzerland)
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11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 2:30 pm |
Endothelial Cell Specification
Discussion Leaders: Alexandria Afonso (McMaster University, Canada) and Katsuhiro Kato (Max Planck Institute for Molecular Biomedicine, Germany)
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1:30 pm - 1:45 pm |
Kristy Red-Horse (Stanford University, USA)
"Development of the Coronary Vasculature"
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1:45 pm - 1:50 pm |
Discussion
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1:50 pm - 2:00 pm |
Geoffrey Stanley (Stanford University, USA)
"Single-Cell Analysis of Coronary Progenitors"
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2:00 pm - 2:05 pm |
Discussion
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2:05 pm - 2:15 pm |
Gregory Farber (Weill Cornell Medicine, USA)
"ADAM10 Regulates Coronary Vascular Morphology and Development"
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2:15 pm - 2:20 pm |
Discussion
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2:20 pm - 2:30 pm |
General Discussion
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2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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3:00 pm |
Seminar Concludes
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