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Enzymes, Coenzymes and Metabolic Pathways

Gordon Research Conference

Emerging Methods and Concepts to Advance Enzyme Chemistry in Biology

July 16 - 21, 2017

Chairs Graham R. Moran and Andrea Mattevi

Vice Chairs Holly R. Ellis and Kay Ahn

Waterville Valley

56 Packard's Road

Waterville Valley, NH, US

Venue and Travel Information

Conference Description

It is 104 years since Michealis and Menten described that the rate of an enzyme reaction is proportional the the enzyme-substrate complex. The Enzymes Coenzymes and Metabolic Pathways Gordon Research Conference has chronicled advances in the study of enzymes and related fields for 70 of those years. In this 70th anniversary year the theme of the ECMP GRC will be part retrospective and part state of the art. The purpose of which is to illustrate the evolution of ideas in this chemically dense area of biochemistry and to show the potential that new tools and methods offer this field of inquiry.

Related Meeting

This GRC will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways (GRS)" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Novel Cofactors and Chemistry Discussion Leader: Eugene Mueller (University of Louisville, USA)
7:40 pm - 8:10 pm	Neil Marsh (University of Michigan, USA) "Prenyl-Flavin: A New Cofactor for Aromatic Decarboxylations"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:45 pm	Robert Hausinger (Michigan State University, USA) "Lactate Racemase and Its Novel Ni-Pincer Cofactor"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Katherine Ryan (University of British Columbia, Canada) "Discovery of a PLP-Dependent Oxidase in the Pathway to the Antibiotic Indolmycin"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Advances in Structural Methodology Discussion Leader: Jennifer DuBois (Montana State University, USA)
9:00 am - 9:30 am	Werner Kühlbrandt (Max Planck Institute of Biophysics, Germany) "High-Resolution Protein Structures by CryoEM - Is Crystallography Obsolete"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Sriram Subramaniam (National Institutes of Health, USA) "Atomic Resolution Cryo-EM of Metabolic Enzymes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Group Photo / Coffee Break
10:50 am - 11:20 am	Abbas Ourmazd (University of Wisconsin-Milwaukee, USA) "Structure and Dynamics from Single-Particle Snapshots"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Carrie Wilmot (University of Minnesota, USA) "MauG Catalysis: A Tale of Ferryl Iron, Radicals and Long Distance Hopping"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Maria Veiga-da-Cunha (de Duve Institute, Catholic University of Louvain, Belgium) "Metabolite Repair, a Neglected but Essential Aspect of Intermediary Metabolism: The Case for Nit1 in the Recycling of Damaged Glutathione"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer: Milka Kostic (Cell Press, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Nucleic Acid Enzymology Discussion Leader: Jeffrey Smiley (Center for Scientific Review, NIH, USA)
7:30 pm - 8:00 pm	Xiaodong Cheng (Emory University, USA) "On the Mechanism of Generation, Recognition, and Erasure of DNA Modifications"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Christopher Schofield (University of Oxford, United Kingdom) "New Metallo-Enzymes Regulating Protein Biosynthesis"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Andrea Musacchio (Max Planck Institute of Molecular Physiology, Germany) "The Role of Catalysis in Mitotic Checkpoint Control over the Cell Cycle"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Enzyme Discovery, Structure and Mechanism Discussion Leader: Nicole Neuman (Molecular Cell, Cell Press, USA)
9:00 am - 9:30 am	Patrick Frantom (The University of Alabama, USA) "Investigations of Regulatory and Functional Diversity in an Enzyme Superfamily"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Martin St. Maurice (Marquette University, USA) "Regulation of Carrier Domain Movements in Pyruvate Carboxylase"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Pablo Sobrado (Virginia Tech, USA) "Noncanonical Reactions Catalyzed by Atypical Flavoenzymes"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Audrey Lamb (University of Kansas, USA) "Unravelling the MSTery"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Renata Reis (Georgia State University, USA) "A Simplified Approach for the Determination of the Bi-Bi Steady-State Kinetic Mechanism of PA0660"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Putting Enzymes to Work Discussion Leader: Michael Knapp (University of Massachusetts Amherst, USA)
7:30 pm - 8:00 pm	F. Peter Guengerich (Vanderbilt University School of Medicine, USA) "Old and New Twists on Cytochrome P450: Desaturation, C-C Bond Cleavage, and Reversible Oxidation of the Thiolate Heme Ligand"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Frances Arnold (California Institute of Technology, USA) "Directed Evolution of Abiological Catalysts Based on Heme Proteins"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Nigel Scrutton (University of Manchester, United Kingdom) "H Transfer and Biocatalysis with Natural and Artificial Coenzymes"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chemical Biology Discussion Leader: Mélanie Hall (University of Graz, Austria)
9:00 am - 9:30 am	Daniel Nomura (University of California, Berkeley, USA) "Using Chemoproteomic Platforms to Map Druggable Hotspots in Human Disease"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Albert Bowers (University of North Carolina at Chapel Hill, USA) "Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Alanna Schepartz (Yale University, USA) "Seeing into Cells"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	Jiasong Li (University of Texas at San Antonio, USA) "Probing the Cofactor Biogenesis in Cysteine Dioxygenase with Unnatural Amino Acid"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Young-Hoon Ahn (Wayne State University, USA) "Chemical Approaches to Investigate Protein Glutathionylation in Stress"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Tonya Zeczycki (Brody School of Medicine at East Carolina University, USA) "Alpha-Synuclein Sensitizes Transglutaminase 2 (TG2) to Ca²⁺ Activation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Biocatalysis Discussion Leader: Aimin Liu (University of Texas at San Antonio, USA)
7:30 pm - 8:00 pm	Kurt Faber (University of Graz, Austria) "Regio-Complementary Carboxylation of Aromatics: Diverging Reactivities Through Different Enzyme Mechanisms"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Stefan Gross (Agios Pharmaceuticals, USA) "Treatment of Inborn Errors of Metabolism by Small Molecule Allosteric Activators"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Jeffrey Moore (Merck & Co., USA) "Development of New and Improved Enzymes for Industrial Biocatalysis"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Computational Enzymology Discussion Leader: Erika Taylor (Wesleyan University, USA)
9:00 am - 9:30 am	Steven Schwartz (University of Arizona, USA) "Protein Dynamics and Catalysis: Evolution and Artificial Design"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Tomasz Borowski (Polish Academy of Sciences, Poland) "Mechanisms of Mononuclear Non-Heme Enzymes Studied with Computational Methods"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA) "Recreating the Evolution of Enzyme Catalysis Over 3.5 Billion Years"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	Max Cryle (Monash University, Australia) "Investigating Glycopeptide Antibiotic Biosynthesis"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom) "A Method to Access Novel Allosteric Regulators and What They Can Teach Us"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Bo Li (University of North Carolina at Chapel Hill, USA) "Biosynthesis of Non-Proteinogenic Amino Acids"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	The Evolving State of the Art Discussion Leader: Thomas Meek (Texas A&M University, USA)
5:30 pm - 6:20 pm	Wilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA) "How Can One Enzyme Act on 30 Different Substrates?"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 7:20 pm	Kenneth Johnson (University of Texas at Austin, USA) "A Century of Enzyme Kinetic Analysis"
7:20 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure