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Sunday
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| 2:00 pm - 9:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Novel Cofactors and Chemistry
Discussion Leader: Eugene Mueller (University of Louisville, USA)
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| 7:40 pm - 8:10 pm |
Neil Marsh (University of Michigan, USA)
"Prenyl-Flavin: A New Cofactor for Aromatic Decarboxylations"
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| 8:10 pm - 8:15 pm |
Discussion
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| 8:15 pm - 8:45 pm |
Robert Hausinger (Michigan State University, USA)
"Lactate Racemase and Its Novel Ni-Pincer Cofactor"
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Katherine Ryan (University of British Columbia, Canada)
"Discovery of a PLP-Dependent Oxidase in the Pathway to the Antibiotic Indolmycin"
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| 9:20 pm - 9:30 pm |
Discussion
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Monday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Advances in Structural Methodology
Discussion Leader: Jennifer DuBois (Montana State University, USA)
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| 9:00 am - 9:30 am |
Werner Kühlbrandt (Max Planck Institute of Biophysics, Germany)
"High-Resolution Protein Structures by CryoEM - Is Crystallography Obsolete"
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| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Sriram Subramaniam (National Institutes of Health, USA)
"Atomic Resolution Cryo-EM of Metabolic Enzymes"
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| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Group Photo / Coffee Break
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| 10:50 am - 11:20 am |
Abbas Ourmazd (University of Wisconsin-Milwaukee, USA)
"Structure and Dynamics from Single-Particle Snapshots"
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| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 12:00 pm |
Carrie Wilmot (University of Minnesota, USA)
"MauG Catalysis: A Tale of Ferryl Iron, Radicals and Long Distance Hopping"
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| 12:00 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Maria Veiga-da-Cunha (de Duve Institute, Catholic University of Louvain, Belgium)
"Metabolite Repair, a Neglected but Essential Aspect of Intermediary Metabolism: The Case for Nit1 in the Recycling of Damaged Glutathione"
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| 12:25 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Milka Kostic (Cell Press, USA)
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Nucleic Acid Enzymology
Discussion Leader: Jeffrey Smiley (Center for Scientific Review, NIH, USA)
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| 7:30 pm - 8:00 pm |
Xiaodong Cheng (Emory University, USA)
"On the Mechanism of Generation, Recognition, and Erasure of DNA Modifications"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Christopher Schofield (University of Oxford, United Kingdom)
"New Metallo-Enzymes Regulating Protein Biosynthesis"
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| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Andrea Musacchio (Max Planck Institute of Molecular Physiology, Germany)
"The Role of Catalysis in Mitotic Checkpoint Control over the Cell Cycle"
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| 9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Enzyme Discovery, Structure and Mechanism
Discussion Leader: Nicole Neuman (Molecular Cell, Cell Press, USA)
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| 9:00 am - 9:30 am |
Patrick Frantom (The University of Alabama, USA)
"Investigations of Regulatory and Functional Diversity in an Enzyme Superfamily"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Martin St. Maurice (Marquette University, USA)
"Regulation of Carrier Domain Movements in Pyruvate Carboxylase"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Pablo Sobrado (Virginia Tech, USA)
"Noncanonical Reactions Catalyzed by Atypical Flavoenzymes"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 12:00 pm |
Audrey Lamb (University of Kansas, USA)
"Unravelling the MSTery"
|
| 12:00 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Renata Reis (Georgia State University, USA)
"A Simplified Approach for the Determination of the Bi-Bi Steady-State Kinetic Mechanism of PA0660"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Putting Enzymes to Work
Discussion Leader: Michael Knapp (University of Massachusetts Amherst, USA)
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| 7:30 pm - 8:00 pm |
F. Peter Guengerich (Vanderbilt University School of Medicine, USA)
"Old and New Twists on Cytochrome P450: Desaturation, C-C Bond Cleavage, and Reversible Oxidation of the Thiolate Heme Ligand"
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| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Frances Arnold (California Institute of Technology, USA)
"Directed Evolution of Abiological Catalysts Based on Heme Proteins"
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| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Nigel Scrutton (University of Manchester, United Kingdom)
"H Transfer and Biocatalysis with Natural and Artificial Coenzymes"
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| 9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Chemical Biology
Discussion Leader: Mélanie Hall (University of Graz, Austria)
|
| 9:00 am - 9:30 am |
Daniel Nomura (University of California, Berkeley, USA)
"Using Chemoproteomic Platforms to Map Druggable Hotspots in Human Disease"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Albert Bowers (University of North Carolina at Chapel Hill, USA)
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Alanna Schepartz (Yale University, USA)
"Seeing into Cells"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Jiasong Li (University of Texas at San Antonio, USA)
"Probing the Cofactor Biogenesis in Cysteine Dioxygenase with Unnatural Amino Acid"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Young-Hoon Ahn (Wayne State University, USA)
"Chemical Approaches to Investigate Protein Glutathionylation in Stress"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Tonya Zeczycki (Brody School of Medicine at East Carolina University, USA)
"Alpha-Synuclein Sensitizes Transglutaminase 2 (TG2) to Ca2+ Activation"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Biocatalysis
Discussion Leader: Aimin Liu (University of Texas at San Antonio, USA)
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| 7:30 pm - 8:00 pm |
Kurt Faber (University of Graz, Austria)
"Regio-Complementary Carboxylation of Aromatics: Diverging Reactivities Through Different Enzyme Mechanisms"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Stefan Gross (Agios Pharmaceuticals, USA)
"Treatment of Inborn Errors of Metabolism by Small Molecule Allosteric Activators"
|
| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Jeffrey Moore (Merck & Co., USA)
"Development of New and Improved Enzymes for Industrial Biocatalysis"
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| 9:20 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Computational Enzymology
Discussion Leader: Erika Taylor (Wesleyan University, USA)
|
| 9:00 am - 9:30 am |
Steven Schwartz (University of Arizona, USA)
"Protein Dynamics and Catalysis: Evolution and Artificial Design"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Tomasz Borowski (Polish Academy of Sciences, Poland)
"Mechanisms of Mononuclear Non-Heme Enzymes Studied with Computational Methods"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Dorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
"Recreating the Evolution of Enzyme Catalysis Over 3.5 Billion Years"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Max Cryle (Monash University, Australia)
"Investigating Glycopeptide Antibiotic Biosynthesis"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom)
"A Method to Access Novel Allosteric Regulators and What They Can Teach Us"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Bo Li (University of North Carolina at Chapel Hill, USA)
"Biosynthesis of Non-Proteinogenic Amino Acids"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 5:30 pm |
Poster Session
|
| 5:30 pm - 7:30 pm |
The Evolving State of the Art
Discussion Leader: Thomas Meek (Texas A&M University, USA)
|
| 5:30 pm - 6:20 pm |
Wilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
"How Can One Enzyme Act on 30 Different Substrates?"
|
| 6:20 pm - 6:30 pm |
Discussion
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| 6:30 pm - 7:20 pm |
Kenneth Johnson (University of Texas at Austin, USA)
"A Century of Enzyme Kinetic Analysis"
|
| 7:20 pm - 7:30 pm |
Discussion
|
| 8:00 pm - 9:00 pm |
Dinner
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am |
Departure
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