Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Origins of Biocatalysis
The program begins with a discussion of how biocatalysis arose in prebiotic times and in the earliest forms of life.
7:40 pm - 8:10 pm
"From Minerals to Metalloproteins: Probing Primitive Pathways of Iron Sulfur Cluster Biosynthesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"'Ox in Hox' and 'The Best Nest': Exploring the Evolutionary History of Nitrogenases and Hydrogenases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"RNA and Protein: A Match Made in the Hadean"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Convergent Allostery in Ribonucleotide Reductase"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mechanism and Evolution of Assembly Line Polyketide Synthases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Ex Vivo Metabolism: Novel Enzyme Cascades to Synthesize Active Pharmaceutical Ingredients"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Multi-Step Substrate Processing and Coordinated Conformational Changes by the Proteasome Molecular Machine"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Enzymatic Spiroketal Formation via Oxidative Rearrangement and Distortion of a Polycyclic Polyketide Backbone"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Biotechnology
7:30 pm - 8:00 pm
"Reconstructing Proteins to Understand Their Evolution and Diversity in Specialized Metabolic Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Metalloprotein Catalysts as Agricultural Biotechnology Tools"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Designed Allosteric Regulation of Metabolic Pathways and What We Can Do with It"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Pathway Evolution and Engineering
9:00 am - 9:30 am
"Enzymes for Lignin and Plastics Conversion"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Insights from Systematic Analysis of Diterpenoid Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Metabolic Alteration Is EASy: A Novel Method for Rapid Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Shifting Roles of Functionally Important Amino Acids During Evolution Contributes to the Difficulty of Explaining Enzyme Specificity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Primordial-Like Enzymes from Bacteria with Reduced Genomes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"1,2,4-Triazine Natural Products. Genome Mining and Biochemical Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymes and Metabolic Pathways in Human Disease
7:30 pm - 8:00 pm
"cGAS-Mediated Biocatalytic Synthesis of Complex Cyclic Dinucleotide STING Agonists Enables Rapid SAR Exploration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Selectivity of Lysine Acetyltransferases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Insights into Heme Metabolism in Malaria Parasites"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Druggable Enzyme Mechanisms and Inhibition
9:00 am - 9:30 am
"Unraveling the Biosynthesis of the Anti-Cancer Agent Azinomycin B"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Inhibition of Biotin Synthase by Acidomycin Reveals Unusual Kinetic Complexity and Suggests a Highly Effective Antimycobacterial Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Structural Insight into Large Domain Movements and Cofactor Specificity of Bacterial HMG-CoA Reductase"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Role of Catalysis and Environmental Regulation in IDH1-Driven Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Tunable Chemistry for Global Discovery of Protein Function and Ligands"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Enzyme Design and Evolution
7:30 pm - 8:00 pm
"Promiscuity, Serendipity and Metabolic Innovation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Interactive Simulation of Enzyme Dynamics and Mechanisms for Design, Optimization and Evolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enzyme Discovery, Engineering and Applications in Biocatalysis: Case Studies for Transaminases, Plastic-Degrading Enzymes and the Degradation of Complex Marine Carbohydrates"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamentals of Catalysis
9:00 am - 9:30 am
"Electric Fields: Enzyme Catalysis and Evolution"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Conformational Dynamics and the Evolution of New Enzyme Functions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Protein Structure and Dynamics Using X-Ray Free-Electron Lasers"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Multiscale Modeling of Complex Enzyme Reactions: From Free Energy Simulations to Consensus Docking"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Closer to the Madding Crowd: Probing Enzyme Catalysis in Cell-Like Environs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: The Future of Enzyme Science
5:30 pm - 6:20 pm
"Combining Cryo-EM with Crystallography to Capture Snapshots of Metalloenzymes in Action"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
"Radical SAM Enzymes: A Past, Present and Future Full of Surprises"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure