Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Single Cell Resolution of Cardiac Epigenetic Landscape
Discussion Leader: Thomas Vondriska (University of California, Los Angeles, United States)
7:40 pm - 8:20 pm
Bing Ren (University of California, San Diego, United States)
"Single-cell Epigenomics in Health and Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epigenetics in Development and Congenital Heart Diseases
Discussion Leader: Maha Abdellatif (Rutgers New Jersey Medical School, United States)
9:00 am - 9:20 am
Richard Harvey (Victor Chang Cardiac Research Institute, Australia)
"Understanding Nkx2-5-Associated Congenital and Adult Heart Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Deepak Srivastava (Gladstone Institutes, United States)
"Cellular Reprogramming Approaches to Heart Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ali Marian (University of Texas, Houston, United States)
"DNA Damage Response in Hereditary Cardiomyopathies"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kaifu Chen (Boston Children's Hospital, Harvard Medical School, United States)
"Epigenetic Landscape Reveals Endothelial Cell Identity Regulator in Cardiovascular Development and Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Enzo Porrello (Murdoch Children's Research Institute, Australia)
"Sex-Specific Remodeling Of The Cardiac Transcriptome And Chromatin Landscape During Human Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sarah Franklin (University of Utah School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Landscape in CV System
Discussion Leader: Gergana Dobreva (Medical Faculty Mannheim, Heidelberg University, Germany)
7:30 pm - 7:50 pm
Guo Huang (University of California, San Francisco, United States)
"Novel Insights From Mammals of Extreme Longevity into Genetic and Epigenetic Regulation of Heart Regeneration and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Li Qian (University of North Carolina at Chapel Hill, United States)
"The Wonderland of Epigenetic Reprogramming"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Nathan Palpant (University of Queensland, Australia)
"Using The Cellular Diversity Of Repressive Chromatin To Identify Cell-Specific Regulatory Factors Controlling Development And Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Players and Mechanisms in CV Epigenetic Regulatory Network
Discussion Leader: Assam El-Osta (Monash University, Australia)
9:00 am - 9:20 am
Matthew Stratton (Ohio State University, United States)
"Characterizing Novel BRD4-Dependent Nuclear Proteins In The Heart"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tamer Sallam (University of California, Los Angeles, United States)
"Non-Coding RNAs Mediated Regulation Of Lipid Metabolism And Vascular Health"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stefanie Dimmeler (Goethe-University Frankfurt, Germany)
"Non-Coding RNA Control Of Epigenetics And Vascular Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ivan Moskowitz (The University of Chicago, United States)
"Epigenetic Regulation of Cardiac Rhythm and Arrhythmias"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Vincent Christoffels (Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands)
"Transcriptional Regulation Of Pacemaker Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Epigenetics
Discussion Leader: John Elrod (Temple University, United States)
7:30 pm - 7:50 pm
Thomas Braun (Max Planck Institute for Heart and Lung Research, Germany)
"The Crosstalk Between Metabolism And Epigenetics Determines Cardiomyocyte Fate"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Anja Karlstaedt (Cedars Sinai Medical Center, United States)
"Interplay Between Epigenetics And Metabolism In Cardio-Oncology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States)
"Epigenetic Regulation Of Hidden Cardiac Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics in Cardiovascular Precision Medicine
Discussion Leader: Gianluigi Condorelli (Humanitas University, Italy)
9:00 am - 9:20 am
Danny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Epigenomic dysregulation of retrotransposons in human diseases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Helle Jorgensen (University of Cambridge, United Kingdom)
"The Regulation Of Vascular Smooth Muscle Cell Plasticity, One Cell At A Time"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Elisabeth Zeisberg (University of Goettingen, Germany)
"DNA Methylation And Mortality In Patients With Aortic Stenosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gabriele Schiattarella (Charité University Medical Center / Max Delbrück Center for Molecular Medicine, Berlin, Germany, Germany)
"Epigenetic Mechanism in HFpEF Pathogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
W. H. Wilson Tang (Cleveland Clinic, United States)
"Epigenetics in Dilated Cardiomyopathy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Regulation Beyond Chromatin
Discussion Leader: Ralf Gilsbach (University of Heidelberg, Germany)
7:30 pm - 7:50 pm
Mirko Völkers (University Hospital Heidelberg, Germany)
"mRNA Metabolism And Translational Control In Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
CHEN GAO (University of Cincinnati, United States)
"mRNA Stability and Regulation in CV Function and Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Late-Breaking Topic
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epigenetic Regulation of Cardiomyocyte Reprogramming
Discussion Leader: Sarah Franklin (University of Utah School of Medicine, United States)
9:00 am - 9:20 am
Sebastian Preissl (University of Freiburg, Germany)
"Dissecting Gene Regulation In The Human Heart Using Single-Cell Multi-Omic"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Llewelyn Roderick (KU Leuven, Belgium)
"Epigenetic Regulation Of Cardiomyocyte Proliferation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Aaron Goldman (The Ohio State University, United States)
"Transcriptional Regulation Of Metabolic Reprogramming During Zebrafish Heart Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
William Pu (Boston Children's Hospital, United States)
"Cardiomyocyte Maturation And Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Roger Foo (National University Singapore, Singapore)
"Non-coding RNA in Cardiomyocyte Maturation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Insights into Heart Development, Disease and Regeneration
Discussion Leader: Johannes Backs (Heidelberg University, Germany)
7:30 pm - 8:10 pm
Eric Olson (University of Texas Southwestern Medical Center, United States)
"New Insights into Heart Development, Disease and Regeneration"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:05 pm
Late-Breaking Topic
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure