Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Single Cell Resolution of Cardiac Epigenetic Landscape
Discussion Leader: Thomas Vondriska (University of California, Los Angeles, United States)
7:40 pm - 8:20 pm
Bing Ren (University of California, San Diego, United States)
"Single-cell Epigenomics in Health and Disease"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Ralf Brandes (Goethe University Frankfurt, Germany)
"RNA-DNA-DNA-Triplex Formation as a Mechanism Controlling Endothelial Gene Expression by lncRNAs"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Manuel Rosa-Garrido (University of Alabama Birmingham, United States)
"CTCF as a Therapeutic Target for Structural Repair of the Failing Heart"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epigenetics in Development and Congenital Heart Diseases
Discussion Leader: Maha Abdellatif (Rutgers New Jersey Medical School, United States)
9:00 am - 9:20 am
Richard Harvey (Victor Chang Cardiac Research Institute, Australia)
"Understanding Nkx2-5-Associated Congenital and Adult Heart Disease"
9:20 am - 9:35 am
Discussion
9:35 am - 9:50 am
Michael Alexanian (Gladstone Institutes / University of California, San Francisco, United States)
"Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:45 am
Ali Marian (University of Texas, Houston, United States)
"DNA Damage Response in Hereditary Cardiomyopathies"
10:45 am - 11:00 am
Discussion
11:00 am - 11:20 am
Kaifu Chen (Boston Children's Hospital, Harvard Medical School, United States)
"Epigenetic Landscape Reveals Endothelial Cell Identity Regulator in Cardiovascular Development and Diseases"
11:20 am - 11:35 am
Discussion
11:35 am - 11:55 am
Enzo Porrello (Murdoch Children's Research Institute, Australia)
"Sex-Specific Remodeling Of The Cardiac Transcriptome And Chromatin Landscape During Human Development"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Chang Jie Mick Lee (National University of Singapore, Singapore)
"Genome-Wide CRISPR screen Identifies an NF2-adherens Junction Mechanistic Dependency for Cardiomyocyte Lineage Specification"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sarah Franklin (University of Utah School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Landscape in CV System
Discussion Leader: Gergana Dobreva (Medical Faculty Mannheim, Heidelberg University, Germany)
7:30 pm - 7:50 pm
Guo Huang (University of California, San Francisco, United States)
"Novel Insights From Mammals of Extreme Longevity into Genetic and Epigenetic Regulation of Heart Regeneration and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Li Qian (University of North Carolina at Chapel Hill, United States)
"The Wonderland of Epigenetic Reprogramming"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Nathan Palpant (University of Queensland, Australia)
"Using Genomic Data to Predict Disease Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Junedh Amrute (Washington University St louis School of Medicine, United States)
"Defining Cardiac Functional Recovery in End-Stage Heart failure at Single Cell Resolution"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Players and Mechanisms in CV Epigenetic Regulatory Network
Discussion Leader: Assam El-Osta (Baker Heart and Diabetes Institute, Australia)
9:00 am - 9:20 am
Matthew Stratton (Ohio State University, United States)
"Characterizing Novel BRD4-Dependent Nuclear Proteins In The Heart"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tamer Sallam (University of California, Los Angeles, United States)
"Non-Coding RNAs Mediated Regulation Of Lipid Metabolism And Vascular Health"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stefanie Dimmeler (Goethe-University Frankfurt, Germany)
"Epigenetic Control in Clonal Hematopoiesis and Impact on Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ivan Moskowitz (The University of Chicago, United States)
"Epigenetic Regulation of Cardiac Rhythm and Arrhythmias"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Vincent Christoffels (Amsterdam University Medical Centers, The Netherlands)
"Transcriptional Regulation Of Pacemaker Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yuliang Feng (Southern University of Science and Technology, China)
"3D Chromatin Architectures and Transcription Regulation in Diabetic Endothelial Dysfunction"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tijana MITIC (University of Edinburgh, United Kingdom)
"Control of Endothelial Cell Function and Arteriogenesis by MEG3:EZH2 Epigenetic Regulation of Integrin Expression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Epigenetics
Discussion Leader: John Elrod (Temple University, United States)
7:30 pm - 7:50 pm
Thomas Braun (Max Planck Institute for Heart and Lung Research, Germany)
"The Crosstalk Between Metabolism And Epigenetics Determines Cardiomyocyte Fate"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Anja Karlstaedt (Cedars Sinai Medical Center, United States)
"Interplay Between Epigenetics And Metabolism In Cardio-Oncology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States)
"Epigenetic Regulation Of Hidden Cardiac Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Chengchen Hu (Rutgers, New Jersey Medical School, United States)
"The Friendly YAP in Compensatory Cardiac Hypertrophy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Francesco Paneni (University Hospital Zurich, Switzerland)
"The Histone Methyltransferase SETD2 Drives Cardiometabolic Heart Failure with Preserved Ejection Fraction"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics in Cardiovascular Precision Medicine
Discussion Leader: Gianluigi Condorelli (Humanitas University, Italy)
9:00 am - 9:20 am
Danny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Epigenomic dysregulation of retrotransposons in human diseases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Helle Jorgensen (University of Cambridge, United Kingdom)
"The Regulation Of Vascular Smooth Muscle Cell Plasticity, One Cell At A Time"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Elisabeth Zeisberg (University of Goettingen, Germany)
"DNA Methylation And Mortality In Patients With Aortic Stenosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gabriele Schiattarella (Charité University Medical Center / Max Delbrück Center for Molecular Medicine, Berlin, Germany, Germany)
"Epigenetic Mechanism in HFpEF Pathogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
W. H. Wilson Tang (Cleveland Clinic, United States)
"Epigenetics in Dilated Cardiomyopathy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Weirui Zhang (National University of Singapore, Singapore)
"Identification of Causal Non-Coding Genetic Variants of Cardiac Function"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Vivien Kmietczyk (University Hospital Heidelberg, Germany)
"The Dynamic RNA Binding Protein Cpeb4 Regulates Cardiomyocyte Growth and Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Regulation Beyond Chromatin
Discussion Leader: Ralf Gilsbach (University of Heidelberg, Germany)
7:30 pm - 7:50 pm
Mirko Völkers (University Hospital Heidelberg, Germany)
"mRNA Metabolism And Translational Control In Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
CHEN GAO (University of Cincinnati, United States)
"mRNA Stability and Regulation in CV Function and Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Shanmukha Kumar Doddi (Univeristätsklinikum Heidelberg, Germany)
"Myocardial Lipid Accumulation Causes Cardiac Inflammation and Dysfunction Through Nr4a1 in a Sex-Dependent Manner"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Andrew Knutson (John A. Burns School of Medicine, University of Hawai'i at Manoa, United States)
"Sexually Dimorphic Heart Phenotypes in Mice Lacking Chromatin Factors in Cardiomyocytes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Michael Kamradt (Cincinnati Children's Hospital Medical Center, United States)
"MPTM1: A Cardiac and Slow Muscle Fiber Enriched Microprotein Essential for Normal Muscle Physiology"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Eric Olson (University of Texas Southwestern Medical Center, United States), Kathy Ivey (Tenaya Therapeutics, United States), Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States) and Saptarsi Haldar (Amgen, United States)
"Industry Collaboration and Commercialization in Epigenomic Medicine"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epigenetic Regulation of Cardiomyocyte Reprogramming
Discussion Leader: Sarah Franklin (University of Utah School of Medicine, United States)
9:00 am - 9:20 am
Sebastian Preissl (University of Freiburg, Germany)
"Dissecting Gene Regulation In The Human Heart Using Single-Cell Multi-Omic"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Llewelyn Roderick (KU Leuven, Belgium)
"Epigenetic Regulation Of Cardiomyocyte Proliferation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Aaron Goldman (The Ohio State University, United States)
"A Cardiac Transcriptional Enhancer is Repurposed During Regeneration to Activate an Anti-proliferative Program"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
William Pu (Boston Children's Hospital, United States)
"Cardiomyocyte Maturation And Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Roger Foo (National University Singapore, Singapore)
"Non-coding RNA in Cardiomyocyte Maturation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Tao Zhong (East China Normal University, China)
"The Gridlock/Hey2 Transcriptional Repressor Impedes Vertebrate Heart Regeneration by Restricting Expression of Lysine Methyltransferase"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Emma Robinson (Anschutz Medical Campus University of Colorado, United States)
"HDAC11 Regulates Gene Expression through Reversible Signal-Dependent Histone Myristoylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Insights into Heart Development, Disease and Regeneration
Discussion Leader: Johannes Backs (Heidelberg University, Germany)
7:30 pm - 8:15 pm
Eric Olson (University of Texas Southwestern Medical Center, United States)
"New Insights into Heart Development, Disease and Regeneration"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Sarah Costantino (Zurich University Hospital, Switzerland)
"Epigenetic Control of Inflammation by Histone Methylation in Cardiometabolic Heart Failure with Preserved Ejection Fraction"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Sylvain Fraineau (University of Rouen Normandy UMR Inserm EnVI U1096, France)
"Ezh2 as an Epigenetic Checkpoint Regulator During Monocyte Differentiation: a Potential Target to Improve Cardiac Repair after Myocardial Infarction"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
