1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Epigenetic Mechanisms of Cardiovascular Disease
Yibin Wang (Duke-NUS Medical School, Singapore) and Federica Accornero (Brown University, United States)
3:45 pm - 4:15 pm
Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States) "HDACs in the Heart: From Academics to Industry and Back"
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Chromatin States in Cardiovascular Disease
Marcello Rubino (Fondazione Humanitas per la Ricerca ETS, Italy) and Yike Zhu (National University of Singapore, Singapore)
7:30 pm - 7:55 pm
Junedh Amrute (Washington University St louis School of Medicine, United States) "Defining Cardiac Functional Recovery in End-Stage Heart Failure at Single Cell Resolution"
7:55 pm - 8:00 pm
8:00 pm - 8:25 pm
Rijan Gurung (National University of Singapore, Singapore) "Spatial Transcriptomics Landscape of Human Atherosclerotic Plaques"
8:25 pm - 8:30 pm
8:30 pm - 8:55 pm
Patrick Laurette (Institute of Experimental Cardiology - Heidelberg University, Germany) "Functional Epigenetic Silencing of Regulatory Elements in Vivo Using an All-In-One CRISPRi AAV"
8:55 pm - 9:00 pm
9:00 pm - 9:25 pm
Javier Laura Frances (Humanitas Research Hospital, Italy) "The novel lncRNA Chheaf-1 regulates cardiac hypertrophy via Rtn4"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Transcriptional and Post-Transcriptional Control of Cardiovascular Disease
Chang Jie Mick Lee (National University of Singapore, Singapore) and Francesco Paolo Ruberto (National University of Singapore, Singapore)
9:00 am - 9:15 am
Marion Delaunay (University of Lausanne, Switzerland) "Investigation of the Role of AKAP2 in Stress-Induced Cardiac Fibrosis"
9:15 am - 9:20 am
9:20 am - 9:40 am
Fadoua El Abdellaoui Soussi (CCHMC, United States) "Chd4/NuRD chromatin remodeling complex regulates the ventricular conduction system"
9:40 am - 9:45 am
9:45 am - 10:05 am
Chengchen Hu (Rutgers, New Jersey Medical School, United States) "The Friendly YAP in Compensatory Cardiac Hypertrophy"
10:05 am - 10:10 am
10:10 am - 10:30 am
Michael Lazaropoulos (Temple University, United States) "Nuclear Acetyl-CoA Metabolism Regulates Chromatin-Dependent Activation of the Myofibroblast Gene Program"
10:30 am - 10:35 am
10:35 am - 10:55 am
Joshua Travers (University of Colorado Anschutz Medical Campus, United States) "Elucidating the Molecular Mechanisms and Cellular Specificity of HDAC Inhibitor Efficacy in Diastolic Dysfunction"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Addressing Inequity in Science in Your Career
Michael Alexanian (Gladstone Institutes / University of California, San Francisco, United States) and Emma Robinson (Anschutz Medical Campus University of Colorado, United States)
1:30 pm - 2:30 pm
Addressing Inequity in Science in Your Career
Federica Accornero (Brown University, United States)
Sarah Franklin (University of Utah School of Medicine, United States)
Matthew Stratton (Ohio State University, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)