Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Epigenetic Mechanisms of Cardiovascular Disease
Discussion Leaders: Yibin Wang (Duke-NUS Medical School, Singapore) and Federica Accornero (Brown University, United States)
3:45 pm - 4:15 pm
Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States)
"HDACs in the Heart: From Academics to Industry and Back"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromatin States in Cardiovascular Disease
Discussion Leaders: Marcello Rubino (Fondazione Humanitas per la Ricerca ETS, Italy) and Yike Zhu (National University of Singapore, Singapore)
7:30 pm - 7:55 pm
Junedh Amrute (Washington University St louis School of Medicine, United States)
"Defining Cardiac Functional Recovery in End-Stage Heart Failure at Single Cell Resolution"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Rijan Gurung (National University of Singapore, Singapore)
"Spatial Transcriptomics Landscape of Human Atherosclerotic Plaques"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Patrick Laurette (Institute of Experimental Cardiology - Heidelberg University, Germany)
"Functional Epigenetic Silencing of Regulatory Elements in Vivo Using an All-In-One CRISPRi AAV"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Javier Laura Frances (Humanitas Research Hospital, Italy)
"The novel lncRNA Chheaf-1 regulates cardiac hypertrophy via Rtn4"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Transcriptional and Post-Transcriptional Control of Cardiovascular Disease
Discussion Leaders: Chang Jie Mick Lee (National University of Singapore, Singapore) and Francesco Paolo Ruberto (National University of Singapore, Singapore)
9:00 am - 9:15 am
Marion Delaunay (University of Lausanne, Switzerland)
"Investigation of the Role of AKAP2 in Stress-Induced Cardiac Fibrosis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:40 am
Fadoua El Abdellaoui Soussi (CCHMC, United States)
"Chd4/NuRD chromatin remodeling complex regulates the ventricular conduction system"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Chengchen Hu (Rutgers, New Jersey Medical School, United States)
"The Friendly YAP in Compensatory Cardiac Hypertrophy"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
Michael Lazaropoulos (Temple University, United States)
"Nuclear Acetyl-CoA Metabolism Regulates Chromatin-Dependent Activation of the Myofibroblast Gene Program"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Joshua Travers (University of Colorado Anschutz Medical Campus, United States)
"Elucidating the Molecular Mechanisms and Cellular Specificity of HDAC Inhibitor Efficacy in Diastolic Dysfunction"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Addressing Inequity in Science in Your Career
Discussion Leaders: Michael Alexanian (Gladstone Institutes / University of California, San Francisco, United States) and Emma Robinson (Anschutz Medical Campus University of Colorado, United States)
1:30 pm - 2:30 pm
Panel Discussion
Addressing Inequity in Science in Your Career
Federica Accornero (Brown University, United States)
Sarah Franklin (University of Utah School of Medicine, United States)
Matthew Stratton (Ohio State University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes