Over 422 million people are living with diabetes with one in three adults having a lifetime risk of developing diabetes or pre-diabetes. The major costs of diabetes relate to its complications, including blindness, amputations, heart attacks and strokes, kidney failure and premature mortality.
Diabetes is a multi-system disease due to complex interactions amongst, albeit not limited to, genetic, perinatal, environmental, lifestyle and dietary factors. The phenotypic heterogeneity points to perturbation of interconnecting biological pathways, which can be modified by early intervention and optimization of internal milieu, as exemplified by the legacy effects of good glycemic control on long term outcomes in prediabetes, type 1 and type 2 diabetes.
Epigenetic modification is an important regulatory mechanism for the temporal and spatial control of gene activity which store, retain, and recall past experiences for shaping present and future behaviors, the so called "cellular memory". The recent advances in technologies have generated big multiomic datasets from clinical and experimental studies, which provide a powerful resource for discovery of new biology of complex disease such as diabetes and cardiovascular-renal disease. In pursuit of this transformational knowledge, new methodologies are needed to create, integrate and translate multi-level evidence into tools and strategies for altering disease trajectories and improving clinical outcomes.
Based on the success of our inaugural meeting in 2018, in this edition of the Gordon Research Conference, we have invited global leaders in the field of clinical, basic, data and pharmaceutical science to deliberate on the linking role of epigenetics in diabetes and its related traits and complications. Through these deliberations, we aim to highlight the interdisciplinary nature in our pursuit of using human data to discover new medicine and technologies for unmet needs. Finally, we welcome young scientists from different disciplines to submit abstracts to the associated Gordon Research Seminar (GRS) and share their work with these thought leaders and foster collaborations to advance our knowledge in the field of epigenetics and/or diabetes and complex diseases.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. Please check back regularly for updates to this information.
- The Linking Role of Epigenome Between Environment and Host Expression
- Clinical Genetics and Precision Medicine
- Using GWAS and Novel Technologies to Define the Genomic Architecture and Expression in Diabetes and Its Complications
- Integrative Approaches to Understand the Regulation of the Human Genome
- Parental Transmission of Disease Risk to Offspring
- Epigenetic Regulation: From Single Cell Genome to Disease Progression
- Molecular Basis for the Variable Trajectories of Diabetic Complications
- Dysregulation of Sensing, Signaling and Secretory Function of Human Islets
- Using the Human Genome to Discover Drugs and Individualize Responses