| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Differentiation and Disease in Diverse Epithelia |
| Discussion Leader: Pierre Coulomb (Hopkins) |
| 7:40 pm - 8:10 pm | Andy McMahon (Harvard)
"Generating cell diversity within the mammalian neural epithelium through Shh signaling" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Connie Cepko (Harvard)
"Cell Fate Determination in the Vertebrate Retina" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Paul Khavari (Stanford)
"Mechanisms Of Genomic Reprogramming During Epidermal Differentiation" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Epidermal Homeostasis and Barrier Function |
| Discussion Leader: Sabine Warner (Zürich) |
| 9:00 am - 9:20 am | Jenny Jiang (University of California, San Francisco) "The Role Of Lipids In The Formation Of The Cutaneous Permeability Barrier And Coordinately Regulating Keratinocyte Differentiation" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Masa Amagai (Keio University, Tokyo, Japan) "Mechanisms of epidermal barrier and its dysfunction in atopic diseases" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Group Photo / Coffee Break |
| 10:30 am - 10:50 am | Ellen Lumpkin (Columbia)
"The Role Of Epidermal Merkel Cells In Touch Sensation" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Zhou Feng Chen (Washington University)
"GRPR: transmitting itch sensation to the spinal cord" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Anj Dlugosz (U. Michigan)
"Cell of Origin and Signaling Activity Influence Hedgehog-Driven Skin Tumorigenesis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Scott Atwood (Stanford) "Canonical polarity protein aPKC iota/lambda regulates Shh signaling during basal cell carcinoma growth" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Therapeutic Applications of Skin Cells |
| Discussion Leader: Angela Christiano (Columbia University, NY) |
| 7:30 pm - 7:50 pm | Danwei Huangfu (Memorial Sloan Kettering)
"Reprogramming Cell Identity for Regenerative Medicine" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Tony Oro (Stanford)
"Determinants of Epithelial Morphogenesis during Tissue Regeneration" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Dennis Roop (Denver)
"Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases" |
| 8:50 pm - 9:00 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Epithelial Morphogenesis |
| Discussion Leader: Radhika Atit (Case Western) |
| 9:00 am - 9:20 am | Ping Chen (Emory, USA)
"Planar Cell Polarization In The Mammalian Inner Ear Sensory Epithelia" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Arjun Raj (Penn)
"Variability In Gene Expression Underlies Incompletely Penetrant Phenotypes" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Angela Christiano (Colombia)
"Danger Signals in the Hair Follicle" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Bruce Morgan (Harvard)
"Size Matters: Genetic Networks In The Dermal Papilla That Regulate Organ Size" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Cheng-Ming Chuong (USC)
"Macro-Environmental Regulation Of Skin Appendage Stem Cell Activity" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Elsa Flores (MD Anderson)
"Unraveling The Diverse Functions Of The TA And DN Isoforms Of P63 In Epidermal Morphogenesis And Stem Cell Maintenance" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Skin Stem Cells |
| Discussion Leader: Doina Tumbar (Cornell) |
| 7:30 pm - 7:50 pm | Phil Jones
"Molecular regulation of stochastic cell fate in normal and preneoplastic epidermal progenitor cells" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Elaine Fuchs (Rockefeller)
"Integrating Cytoskeletal Dynamics With Stem Cells in Morphogenesis and Wound Repair" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Fiona Watt (MRC)
"Reciprocal Signaling Between Adult Epidermis And Dermis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | George Cotsarelis (Penn)
"Factors influencing hair follicle neogenesis following wounding" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Role of Immune System in Epithelial Biology and Disease |
| Discussion Leader: Stuart Yuspa (NIH, USA) |
| 9:00 am - 9:30 am | Keynote: Joan Brugge (Harvard)
"Modeling Morphogenesis and Oncogenesis of Epithelial Cells in Culture" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Michael Girardi (Yale)
"Local Immune Influences on Cutaneous Carcinogenesis" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:10 am | Freddy Radtke (EPFL ISREC, Switzerland)
"TSLP-Mediated Inflammation and Skin Cancer" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Birgit Lane (Institute of Medical Biology, Singapore)
"Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Christophe Cataisson (NCI)
"IL-1a Is A Major Effector Of The Ras Oncogenic Program" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Issues Arising Session |
| Discussion Leader: Sarah Millar (U Penn) |
| 7:30 pm - 7:40 pm | Markus Kretz (Stanford)
"Epidermal homeostasis is regulated by the functionally antagonistic long non-coding RNAs, ANCR and TINCR" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Vladimir Botchkarev (University Of Bradford / Boston University) "The genome organizer protein Satb1 controls the establishment of tissue-specific chromatin organization during epidermal development"
|
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Carien Niessen (University of Cologne) "Polarity signaling controls epidermal morphogenesis, homeostasis and stem cell behavior" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Marja Mikkola (University of Helsinki) "Molecular mechanisms regulating dermal condensate formation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Amanda Nelson (Johns Hopkins) "Prostaglandin D2 levels inversely correlate with hair follicle regeneration in mice" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Elena Ezhkova (Mount Sinai, NY) "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Valerie Horsley (Yale) "Extrinsic Regulation of Follicular Stem Cells by Adipocytes" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Tudorita Tumbar (Cornell University) "Runx1 is a master regulator of adult hair follicle stem cells activation, emergence, and maintenance, and promotes skin tumorigenesis" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Polarity, Adhesion, and Cytoskeleton |
| Discussion Leader: Tung-Tien (Henry) Sun (NYU, NY) |
| 9:00 am - 9:20 am | Greg Longmore (Washington University)
"Rho Gtpases In Remodeling Epithelia, In Vivo" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Pierre Coulombe (Johns Hopkins University)
"Non-Canonical Functions Of Keratin In Skin Epithelia" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Kathy Green (Northwestern, USA)
"Desmosomes: Signaling Scaffolds in Epidermal Morphogenesis" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Terry Lechler (Duke)
"Generation and Function of Cortical Microtubules in the Epidermis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Benjamin Yu (UCSD)
"Discovery Of Small RNAs In The Human Hair Shaft: Implications For Molecular And Genetic Basis For Human Variation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Sarah Millar (U Penn USA)
"HDAC1 and HDAC2: keeping the embryonic epidermis young" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Novel Regulatory Mechanisms |
| Discussion Leader: Bogi Andersen (Irvine, CA) |
| 7:30 pm - 7:50 pm | Paolo Dotto (Lausanne; Harvard)
"Notch And Calcineurin Signaling In Integrated Control Of Skin Homeostasis And Carcinogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Howard Chang (Stanford USA)
"Genome regulation by long noncoding RNAs" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Harinder Singh (Genentech)
"Developmental Control Of Gene Activity Via Compartmentalization At The Nuclear Lamina" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Rui Yi (Boulder)
"microRNA-mediated regulation of maintenance and differentiation of skin stem cells" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |