Adult epithelia regenerate during adult life due to the constant activity of stem cell pools. Stem cells maintain tissue homeostasis and repair injury by close communication with their tissue environment, known as the "niche". Niches are complex, structured arrays of different cell types that guide tissue stem cell dynamics. The ultimate goal of understanding epithelial stem cell regulation is to repair or replace cells or organs damaged by injury, disease, and aging. The strategies vary from generating cell types and tissues in a dish for transplantation purposes, to directly stimulating the damaged organ in the living organism. The Gordon Research Conference on Epithelial Stem Cells and Niches will focus on comparative principles of adult epithelial stem cell dynamics and niche signaling in the homeostasis of different tissues. This conference will include work on the molecular control of stem cell function from the epidermis and its appendages, intestine, lung, mammary gland, cornea, prostate, and emerging work from other epithelial tissues. For the 2020 meeting, we have built a scientific program that emphasizes key cutting edge areas in epithelial biology, including organoid techniques, imaging and single cell analysis, bioengineering, systems biology, modeling disease, DNA repair, aging, and immune regulation.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. Please check back regularly for updates to this information.
- Keynote Session: Stem Cells of the Lung and Mammary Gland
- Mechanisms of Stem Cell Maintenance
- Niche Regulation of Tissue Homeostasis
- Bioengineering and Systems Approaches to Studying Stem Cell Function
- Regulation of Stem Cell Differentiation
- Stem Cells and Cancer
- Immune Regulation and Aging
- Niche Dysregulation in Cancer
- Generation of Tissue Architecture