| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | FROM EXOCYTOSIS TO SYNAPTIC SCALING |
| Discussion Leader: Christophe Mulle (CNRS, Bordeaux) |
| 7:40 pm - 8:20 pm | Gina Turrigiano (Brandeis University) "Homeostatic synaptic scaling" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Reinhard Jahn (MPIBC, Göttingen) "Mechanism of SNARE-mediated exocytosis of synaptic vesicles" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GLUTAMATE RECEPTOR STRUCTURE AND EXCITATORY SYNAPTIC COMPLEXES |
| Discussion Leader: Mark Mayer (NIH, Bethesda) |
| 9:00 am - 9:25 am | Eric Gouaux (Vollum Institute, Portland) "Atomic structure and molecular mechanism at chemical synapses" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Xiaobing Chen (NIH, Bethesda) "EM tomographic fine structure of the postsynaptic density" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break / Group Photo |
| 10:30 am - 10:55 am | Seth Grant (Wellcome Trust Sanger Institute, Cambridge) "Synaptic evolution, molecular networks and the emergence of behavior" |
| 10:55 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Jean-Philippe Pin (Institut de Génomique Fonctionnelle, Montpellier) "Activation and allosteric modulation of metabotropic glutamate receptors" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:05 pm | Pierre Paoletti (Ecole Normale Supérieure, Paris) "How NR2 subunits differentially control NMDA receptor channel activity" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk: Gabriela Popescu (University of Buffalo)
"Distinct gating modes determine the biphasic relaxation of NMDA receptor currents" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | TRAFFICKING AND MOLECULAR ORGANIZATION AT EXCITATORY SYNAPSES |
| Discussion Leader: Jeremy Henley (University of Bristol) |
| 5:30 pm - 5:55 pm | Katherine Roche (NINDS, Bethesda) "Regulation of glutamate receptors: Trafficking and phosphorylation" |
| 5:55 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:35 pm | Michael Ehlers (Duke University) "Protein machinery for postsynaptic trafficking at glutamate synapses" |
| 6:35 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Daniel Choquet (Institut Francois Magendie, Bordeaux) "The interplay between the function and regulation of AMPAR trafficking" |
| 7:15 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | EXCITATORY SYNAPSES - INSIGHTS FROM MODEL SYSTEMS |
| Discussion Leader: Andres Villu Maricq (University of Utah) |
| 9:00 am - 9:15 am | Short Talk: Nikolaj Klocker (University of Freiburg)
"Cornichons facilitate early anterograde transport of AMPARs" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Short Talk: Thomas Blanpied (University of Maryland)
"Local dynamics of actin polymerization within dendritic spines" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Kang Shen (Stanford University) "Synapse and circuit development in C. elegans" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:40 am - 11:05 am | Stephan Sigrist (Freie Universitat, Berlin) "Shedding light on active zone structure and function in Drosophila" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Yishi Jin (University of California, San Diego) "Synapse formation in C. elegans" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Short Talk: Michisuke Yuzaki (Keio University)
"Cbln family proteins and their receptors: unique presynaptic organizers in the cerebellum and hippocampus" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk: Clarissa Waites (Stanford University)
"Piccolo and Bassoon are required for the structural and functional integrity of excitatory synapses" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | VESICULAR AND PRESYNAPTIC MECHANISMS AT EXCITATORY SYNAPSES |
| Discussion Leader: Reinhard Jahn (MPIBC, Göttingen) |
| 5:30 pm - 5:55 pm | Richard Tsien (Stanford University) "Presynaptic adaptation of unitary synaptic events" |
| 5:55 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:35 pm | Robert Edwards (University of California, San Francisco) "Synaptic vesicle recycling" |
| 6:35 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Yukiko Goda (University College London) "Regulation of neurotransmitter release by synaptic adhesion proteins" |
| 7:15 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GLUTAMATE RECEPTOR SIGNALING AND MODULATION AT EXCITATORY SYNAPSES |
| Discussion Leader: Richard Tsien (Stanford University) |
| 9:00 am - 9:25 am | Ryohei Yasuda (Duke University) "Glutamate receptor signal transduction at single dendritic spines" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Andres Villu Maricq (University of Utah)
"AMPAR signaling complexes" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:40 am - 11:05 am | Roger Nicoll (University of California, San Francisco) "How many TARPs bind to an AMPA receptor" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Hannah Monyer (University of Heidelberg) "Novel proteins modulating AMPA receptor activity" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Short Talk: Regina Dahlhaus (University of British Columbia)
"Over-expression of Neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk: Nathalie Sans (Universite Bordeaux II)
"Scribble1 regulates neuronal maturation, synaptic plasticity and memory" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session III |
| 5:30 pm - 7:30 pm | STRUCTURAL AND FUNCTIONAL SYNAPTIC PLASTICITY |
| Discussion Leader: Gina Turrigiano (Brandeis) |
| 5:30 pm - 5:55 pm | Valentin Nägerl (CNRS, Bordeaux) "STED microscopy of living synapses" |
| 5:55 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:35 pm | Suzanne Zukin (Albert Einstein College of Medicine) "Epigenetic remodeling of synaptic AMPA receptor phenotype" |
| 6:35 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:15 pm | Christian Luscher (University of Geneva) "Drug-evoked synaptic plasticity: a key to addiction?" |
| 7:15 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PATTERNS OF SYNAPTIC DYSFUNCTION AND DISEASE |
| Discussion Leader: Juan Lerma (Instituto de Neurociencias de Alicante) |
| 9:00 am - 9:25 am | Timothy Murphy (University of British Columbia) "In vivo imaging of plastic changes to synapses/circuits during ischemia and recovery" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Monica DiLuca (University of Milan) "Role of ADAM10 in the glutamatergic postsynaptic density: bridging synaptic failure and amyloid cascade" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:40 am - 11:05 am | Nils Brose (MPIEM, Göttingen) "Synaptic and behavioral dysfunction in animal models of mongenic heritable autism" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Claudia Bagni (Katholieke Universiteit Leuven) "Fragile X syndrome and synaptic function" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Short Talk: Yann Humeau (University of Strasbourg)
"Synaptic physiology in mouse models of mental retardation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk (TBA) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session IV |
| 5:30 pm - 6:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 6:00 pm - 7:30 pm | THE NEXT FRONTIER - APPROACHES TO NETWORKS |
| Discussion Leader: Gary Westbrook (Vollum Institute, Portland) |
| 6:00 pm - 6:25 pm | Michael Häusser (University College London) "Dendritic computation" |
| 6:25 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:20 pm | Edvard Moser (Norwegian University of Science and Technology, Trondheim)
"Grid cells, entorhinal circuits and hippocampal memory" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |