Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: A Multiscale View of the Synapse: From Nanomachines to Circuits and Behavior
Discussion Leaders: Ege Kavalali (Vanderbilt University, USA) and Yael Stern-Bach (Hebrew University of Jerusalem, Israel)
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7:40 pm - 8:20 pm |
Eric Gouaux (Vollum Institute, Oregon Health and Science University, USA)
"Structure and Mechanism of AMPA Receptors and Their Complexes with Auxiliary Subunits"
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8:20 pm - 8:35 pm |
Discussion
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8:35 pm - 9:15 pm |
Peter Jonas (Institute of Science and Technology Austria, Austria)
"Structure, Function and Plasticity of a Central Glutamatergic Synapse"
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9:15 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Glutamate Receptor Structure and Dynamics
Discussion Leader: Mark Mayer (National Institutes of Health, USA)
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9:00 am - 9:20 am |
Ingo Greger (Medical Research Council, United Kingdom)
"Structure and Organization of Heteromeric AMPA Receptors"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Hiro Furukawa (Cold Spring Harbor Laboratory, USA)
"Structure and Reagents of NMDA Receptors"
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9:50 am - 10:00 am |
Discussion
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10:00 am - 10:20 am |
Jean Philippe Pin (University of Montpellier / CNRS, INSERM, France)
"Dynamics and Allosteric Properties of mGluRs: New Possibilities to Control Brain Functions"
|
10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:20 am |
Yael Stern-Bach (Hebrew University of Jerusalem, Israel)
"Molecular Regulation of AMPA Receptors by Interacting Proteins"
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11:20 am - 11:30 am |
Discussion
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11:30 am - 11:50 am |
Bernd Fakler (University of Freiburg, Germany)
"Biogenesis of AMPARs and Its Impact on Excitatory Neurotransmission and Activity-Dependent Plasticity"
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11:50 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Terunaga Nakagawa (Vanderbilt University School of Medicine, USA)
"Structure and Mechanism of an AMPAR-Auxiliary Subunit Complex Without Claudin Homologues"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Teddy Grand (Ecole Normale Supérieure (INSERM/CNRS), France)
"New Insights into Excitatory Glycine GluN1/GluN3 NMDA Receptors"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Nicole Calakos (Duke University Medical Center, USA) and Marina Wolf (Oregon Health & Science University, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
New Tools and Methodologies to Explore Synaptic Function
Discussion Leader: Pablo Castillo (Albert Einstein College of Medicine, USA)
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7:30 pm - 7:50 pm |
Ryohei Yasuda (Max Planck Florida Institute for Neuroscience, USA)
"Biochemical Computation in Post-Synapses"
|
7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Ehud Isacoff (University of California, Berkeley, USA)
"Single Molecule Analysis of Glutamate Receptor Conformational Dynamics"
|
8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Moritz Helmstaedter (Max Planck Institute for Brain Research, Germany)
"Connectomic Analysis in the Cerebral Cortex"
|
8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
David Bredt (Janssen Pharmaceutical Companies, USA)
"Getting a Handle on Neuropharmacology by Targeting Receptor Associated Proteins"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Development and Maturation of Excitatory Synapses
Discussion Leader: Camilla Bellone (University of Geneva, Switzerland)
|
9:00 am - 9:20 am |
Suzanne Zukin (Albert Einstein College of Medicine, USA)
"A Single Phosphorylation Site on the NMDAR GluN2B Subunit Regulates Hippocampal Synaptic Plasticity"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Chris McBain (National Institute of Child Health and Human Development, NIH, USA)
"A Comprehensive Investigation of Human Hippocampal Mossy Fiber Transmission and Plasticity"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Chinfei Chen (Boston Children's Hospital / Harvard Medical School, USA)
"Sensory Integration in the Visual Thalamus"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Peter Scheiffele (Biozentrum, University of Basel, Switzerland)
"Alternative Splice Codes for Neuronal Identity and Synapse Specification"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Beth Stevens (Boston Children's Hospital, Harvard Medical School, USA)
"How Microglia Prune Specific Synapses in Health and Disease"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Angela Mabb (Georgia State University, USA)
"Ubiquitination at Excitatory Synapses"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Cécile Charrier (Institut de Biologie de l'École Normale Supérieure, France)
"Hijacking of a Glutamate Receptor by Inhibitory Synapses"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Scaffolding and Signaling at Excitatory Synapses
Discussion Leader: Jeffrey Diamond (National Institutes of Health, USA)
|
7:30 pm - 7:50 pm |
Katherine Roche (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Dynamic Regulation of Postsynaptic Proteins: Insights from Rare Variants"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Mark Dell'Acqua (University of Colorado School of Medicine, USA)
"Regulation of Synaptic Plasticity by Calcium-Permeable AMPA Receptors and Anchored Kinase/Phosphatase Signaling"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Michisuke Yuzaki (Keio University School of Medicine, Japan)
"Regulation of iGluRs by Extracellular Scaffolding Proteins"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Seth Grant (University of Edinburgh, United Kingdom)
"The Synaptome in Space and Time"
|
9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Experience-Dependent Modulation of Synapses and Circuits
Discussion Leader: Chinfei Chen (Boston Children's Hospital / Harvard Medical School, USA)
|
9:00 am - 9:20 am |
Wenbiao Gan (Skirball Institute of Biomolecular Medicine, NYU Langone Health, USA)
"Experience and Sleep-Dependent Dendritic Spine Plasticity and Maintenance"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Anthony Holtmaat (University of Geneva, Switzerland)
"Context-Dependent Dynamics of Functional Selectivity in Somatosensory Cortex"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Christian Luscher (University of Geneva, Switzerland)
"Plasticity of Excitatory Synaptic Transmission Underlying Maladaptive Behavior in Addiction"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Thomas Sudhof (Stanford University, USA)
"Switching Relationships at the Synapse: Neurexins and Its Partners"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Alfredo Kirkwood (Johns Hopkins University, USA)
"Multiple Mechanisms for Synaptic Homeostasis in Visual Cortex"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Ming-fai Fong (Massachusetts Institute of Technology, USA)
"Experience-Dependent Plasticity in Visual Disability, Recovery and Enhancement"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Alberto Cruz-Martín (Boston University, USA)
"Excitatory Synaptic Dysfunction and Altered Social Behavior with Overexpression of Schizophrenia-Associated Gene C4"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Synaptopathies: Synaptic Dysfunction in Neuropsychiatric Disorders
Discussion Leader: Hey-Kyoung Lee (Johns Hopkins University, USA)
|
7:30 pm - 7:50 pm |
Nicole Calakos (Duke University Medical Center, USA)
"New Implications for Phospho-eIF2alpha-Dependent Protein Synthesis in the Control of Movement"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Giovanna Mallucci (University of Cambridge, United Kingdom)
"Cooling Synapses and Neuroprotection"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Marina Wolf (Oregon Health & Science University, USA)
"Plasticity Regulating the Strength of Drug Craving"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
A. Kimberley McAllister (University of California, Davis, USA)
"Novel Roles for Immune Molecules in Regulating Synapse Formation in Health and Disease"
|
9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Synaptic Plasticity and Memory
Session in memory of John Lisman.
Discussion Leader: Alfredo Kirkwood (Johns Hopkins University, USA)
|
9:00 am - 9:20 am |
Robert Malenka (Stanford University School of Medicine, USA)
"Synaptic Cell Adhesion Proteins and LTP"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Daniel Choquet (CNRS, France)
"Linking AMPA Receptor Dynamics to Synaptic Plasticity and Learning"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Roger Nicoll (University of California, San Francisco, USA)
"The NMDA Receptor/CaMKII Complex Is the Central Signaling Hub at Excitatory Synapses"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Richard Huganir (Johns Hopkins University School of Medicine, USA)
"Regulation of AMPA Receptors in Cognition and Cognitive Disorders"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Robert Malinow (University of California, San Diego, USA)
"Synapses in Health and Disease"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Lenora Volk (University of Texas Southwestern Medical Center, USA)
"The Role of KIBRA in Memory: From Molecules to Circuits"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Kaoutsar Nasrallah (Albert Einstein College of Medicine, USA)
"Retrograde Adenosine/A2A Signaling at a Key Excitatory Synapse in the Hippocampus"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Novel Signaling Mechanisms at Excitatory Synapses
Discussion Leader: Juan Lerma (Instituto de Neurociencias, CSIC-UMH, Spain)
|
7:30 pm - 7:50 pm |
Ege Kavalali (Vanderbilt University, USA)
"Glutamatergic Synaptic Signaling at Rest"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Julie Perroy (Institute of Functional Genomics, CNRS, France)
"Glutamate Receptosome Dynamics at Excitatory Synapses: Functional Deficiencies in Autism Spectrum Disorders"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Per Jesper Sjöström (McGill University, Canada)
"Unorthodox NMDA Receptor Signaling in Neocortical Plasticity"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Isabel Perez-Otaño (Institute of Neurosciences, Miguel Hernández University of Elche, Spain)
"Postnatal Emergence of mTOR-Dependent Protein Translation"
|
9:20 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|