The demonstration that extracellular vesicles (EVs), carrying RNA, DNA, proteins and lipids, play important roles in maintaining human health as well as contribute to driving disease has opened up a whole new field of research across all areas of biology, from development to host-pathogen interactions to tissue regeneration. The objective of this 3rd Gordon Research Conference (GRC), entitled "Understanding Extracellular Vesicle Biogenesis and Composition for Detection and Treatment of Diseases", is to encompass this rapidly growing research field of extracellular vesicles and extracellular RNA, bringing together a range of basic and clinical investigators focusing on issues of biologic actions of vesicles and clinical potential of vesicles both as diagnostic biomarkers and therapeutics. Recent studies have demonstrated the capacity of vesicles to reverse disease states or heal injured tissue in different animal models as well as to serve as biomarkers in a variety of human diseases. These exciting, recent results suggest that EVs may provide novel therapeutic strategies for treating a number of devastating human diseases and conditions. Indeed, clinical trials with EVs have already started for the treatment of cancer and several other diseases. Also, recent research has demonstrated critical role played by EVs in intercellular communication and revealed that EVs are more heterogeneous with more diverse biological activities than has previously been appreciated. Increasing numbers of studies now are addressing the biogenesis, intrinsic characteristics and the multiple applications of EVs. In addition, new approaches for quantitating EVs as well as analyzing their biodistribution in vivo are being developed. All of these timely and significant areas of EV biology will be discussed at this GRC.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2019. Please check back for updates.
- Keynote Session: Physiologic and Pathologic Roles of EVs
- Biogenesis and Composition of EVs
- New Technologies for Quantitating and Analyzing EVs
- Role of Endogenous EVs in Driving Disease Pathology
- EVs as Delivery Vehicles for Drugs and RNAs
- Novel Therapeutic Applications of EVs
- EVs in Host-Pathogen Interactions
- Stem Cell EVs for Regenerative Medicine
- Current Clinical Trials with EVs