Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Physiologic and Pathologic Roles of EVs
Discussion Leader: Edit Buzas (Semmelweis University, Hungary)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
Clotilde Théry (Institut Curie / INSERM U932, France)
"Basic Biology of Extracellular Vesicles"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
David Lyden (Weill Cornell Medicine, United States)
"Extracellular Vesicles in Cancer Biology"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biogenesis and Composition of EVs
Discussion Leader: Clotilde Théry (Institut Curie / INSERM U932, France)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Deborah Goberdhan (University of Oxford, United Kingdom)
"Endosomal Origin Contributes to the Heterogeneity of Exosome Content and Function"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
Crislyn D'Souza-Schorey (University of Notre Dame, United States)
"Biogenesis and Biology of Tumor Microvesicles"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Anthony Ferrante (Columbia University, United States)
"Lipid EVs and Adipose Tissue Homeostasis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Jennifer Petersen (National Institute of Child Health and Human Development, NIH, Bethesda, MD, United States)
"R64 - Endothelial Cells Release Hybrid Extracellular Vesicles: Microvesicles That Secrete Exosomes"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Curtis Logan (Concordia University, Canada)
"W8: Humanization of Yeast EV Biogenesis Machinery to Investigate Functional Evolutionary Conservation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Catarina Meyer (CEDOC Nova Medical School UNL, Portugal)
"LAMP2A and Specific Peptide Motifs Regulate the Loading of Proteins into Exosomes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Janet Sorrells (University of Illinois at Urbana-Champaign, United States)
"Characterization of Metabolic Signatures of Extracellular Vesicles in Breast Cancer Using Label-Free Nonlinear Optical Microscopy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Edit Buzas (Semmelweis University, Hungary) and Jieun Lee (AgeX Therapeutics Inc., United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Technologies for Quantitating and Analyzing EVs
Discussion Leader: Adrian Morelli (University of Pittsburgh, United States)
7:30 pm - 7:55 pm
Louise Laurent (University of California, San Diego, United States)
"Systematic Evaluation of exRNA Isolation and Analysis Methods for Biomarker Studies"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Shannon Stott (Massachusetts General Hospital and Harvard Medical School, United States)
"Microfluidics for Cell-Specific EV Isolation in Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Juan Falcon-Perez (CIC bioGUNE, Spain)
"From the EV-Omics Era to Single-Vesicle Analysis: Starting the EV Puzzle Game"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Colin Hisey (The Ohio State University, United States)
"Autoencoder-Enabled Quantitative Detection of Extracellular Vesicle Mixtures Using Nanoplasmonic Sensors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Yong Zeng (University of Florida, United States)
"EV Profiling Nanochips for Cancer Diagnosis and Monitoring"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Role of Endogenous EVs in Driving Disease Pathology
Discussion Leader: David Lyden (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Andrew Hill (La Trobe University, Australia)
"EVs and Protein Misfolding in Neurodegenerative Diseases"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lucia Languino (Thomas Jefferson University, United States)
"Small Extracellular Vesicle Reprogramming of Cancer Cells and the Tumor Microenvironment"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Dolores Di Vizio (Cedars-Sinai Medical Center, United States)
"Heterogeneous Induction of Interferon Pathway in the Tumor Microenvironment by Different Populations of Cancer-Derived Extracellular Vesicles"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Frederik Verweij (Utrecht University, The Netherlands)
"Exploiting CD63-Based Reporter Systems to Image EV Release in Vitro and in Vivo"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Inbal Wortzel (Weill Cornell Medicine, United States)
"R90 - EV-DNA Primes the Anti-Tumor Immunity to Prevent Metastatic Progression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Vanessa Veilleux (Université de Moncton and Atlantic Cancer Research Institute, Canada)
"Horizontal Transfer of Functional Platelet-Derived Mitochondria-Containing Microparticles Modulates the Bioenergetic State of Breast Cancer Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
EVs as Delivery Vehicles for Drugs and RNAs
Discussion Leader: Andrew Hill (La Trobe University, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Pieter Vader (University Medical Center Utrecht, The Netherlands)
"Extracellular Vesicle-mediated RNA Delivery: from Mechanistic Insights towards Therapeutic Applications"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Zachary Greenberg (University of Florida, United States)
"R31 - An End-to-End Machine Learned Peptide Aptamer Strategy to Develop Translational Precision Extracellular Vesicle Therapeutics"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Minh Le (National University of Singapore, Singapore)
"R48 - Red Blood Cell Extracellular Vesicles are a Native Anti-Viral Therapeutic Agent and Effective Oligonucleotide Drug Carrier Against SARS-CoV-2"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Ana Salazar Puerta (The Ohio State University, United States)
"R72 - Designer Extracellular Vesicle Therapies for Acute Respiratory Distress Syndrome"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
David Rufino-Ramos (Center for Neuroscience and Cell Biology of University of Coimbra, Portugal, Portugal)
"R70 - Extracellular Communication in the Brain Through Functional Transfer of CRE ExRNA"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
EVs in Host-Pathogen Interactions
Discussion Leader: Esther Nolte-'t Hoen (Utrecht University, The Netherlands)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
Arne Weiberg (LMU Munich, Germany)
"RNA Crosstalk and EVs in Plant-Pathogen Interaction"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
Navneet Dhillon (University of Kansas Medical Center, United States)
"Lessons Learned from EVs and COVID-19 Pandemic: Mediators and Markers of the Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Stanley Lemon (UNC Chapel Hill, United States)
"Biogenesis and Composition of the Hepatovirus Quasi-Envelope"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Hernando A del Portillo (Barcelona Institute for Global Health (ISGlobal) and Germans Trias i Pujol Research Institute (IGTP), Spain)
"Circulating EVs from Plasmodium Vivax Patients Facilitate Cryptic Erythrocytic Infections"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Muthiah Kumaraswami (Houston Methodist Research Institute, United States)
"R45 - Bacterial Communication and Virulence Regulation via Extracellular Vesicles"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic Applications of EVs
Discussion Leader: Eva Rohde (Paracelsus Medical University and SALK, Austria)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Adrian Morelli (University of Pittsburgh, United States)
"Graft-Derived Extracellular Vesicles as Initiators of the Anti-Donor Response in Transplantation"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Bharat Ramratnam (Alpert Medical School, Brown University, United States)
"Extracellular Vesicles and HIV-1 Latency"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Brian Eliceiri (University of California, San Diego, United States)
"R20 - Serpin-Loaded EVs Reverse the Impaired Wound Healing of a Diabetic Mouse Model"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Tianpeng Zhang (University of Minnesota, United States)
"R93- Reduce Senescence by Using a MicroRNA Cocktail Recipe"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Stem Cell EVs for Regenerative Medicine
Discussion Leader: Juan Falcon-Perez (CIC bioGUNE, Spain)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Sai Kiang Lim (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Mitigating Anticipated Risks in Manufacturing and Translating MSC-EVs for Regenerative Medicine"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Benedetta Bussolati (Università di Torino, Italy)
"Renal Repair: From Stem Cell to Biofluid EVs"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Ewa Zuba-Surma (Jagiellonian University, Krakow, Poland, Poland)
"Pluripotent Stem Cell-Derived EVs: Biological Properties and Perspectives on Use in Tissue Repair"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Hernán González-King Garibotti (AstraZeneca, Sweden)
"R29 - Evaluating the Suitability of Small Extracellular Vesicles Derived from Immortalized Mesenchymal Stromal Cells for Acute Myocardial Ischemia Treatment"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Vidyanand (Anand) Sasidharan (Stowers, United States)
"R73 - Extracellular Vesicles Mediated Cell-Cell Communication is Required for Planarian Tissue Maintenance and Regeneration"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Yoon-Kyoung Cho (UNIST/ IBS Center for Soft and Living Matter, South Korea)
"Programmed Exosome Fusion for Artificial Organelles"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Subree Subramanian (University of Minnesota, United States)
"Tumor Cell Secreted Extracellular Vesicles Regulate T Cell Priming and Regulate Immune Response in Colorectal Cancer"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
EV Therapies: Concepts and Clinical Trials
Discussion Leader: Sai Kiang Lim (Institute of Molecular and Cell Biology, A*STAR, Singapore)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:05 pm
Maria Brizzi (University of Turin, Italy)
"Autologous Serum-Derived EVs to Treat Venous Trophic Lesions not Responsive to Conventional Treatments"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:35 pm
Eva Rohde (Paracelsus Medical University and SALK, Austria)
"Regulatory Needs for the Clinical Evaluation of Stromal Cell-derived Native EV-Therapeutics"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Daniel Levy (University of Maryland - College Park, United States)
"R50 - Investigating the Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Extracellular Vesicles"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Stefania Bruno (Department of Medical Sciences, University of Torino, Italy)
"Extracellular Vesicles Derived From Human Liver Stem Cells Attenuate Chronic Renal Injury in two Different Animal Models of Chronic Kidney Disease"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
