Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Physiologic and Pathologic Roles of EVs
Discussion Leader: Edit Buzas (Semmelweis University, Hungary)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
Clotilde Théry (Institut Curie / INSERM U932, France)
"Basic Biology of Extracellular Vesicles"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
David Lyden (Weill Cornell Medicine, United States)
"Extracellular Vesicles in Cancer Biology"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biogenesis and Composition of EVs
Discussion Leader: Clotilde Théry (Institut Curie / INSERM U932, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Deborah Goberdhan (University of Oxford, United Kingdom)
"Endosomal Origin Contributes to the Heterogeneity of Exosome Content and Function"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Stanley Lemon (UNC Chapel Hill, United States)
"Biogenesis and Composition of the Hepatovirus Quasi-Envelope"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Crislyn D'Souza-Schorey (University of Notre Dame, United States)
"Biogenesis and Biology of Tumor Microvesicles"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Anthony Ferrante (Columbia University, United States)
"Lipid EVs and Adipose Tissue Homeostasis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Closing Remarks
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Edit Buzas (Semmelweis University, Hungary) and Dana Larocca (AgeX Therapeutics Inc, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Technologies for Quantitating and Analyzing EVs
Discussion Leader: Adrian Morelli (University of Pittsburgh, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Louise Laurent (University of California, San Diego, United States)
"Systematic Evaluation of exRNA Isolation and Analysis Methods for Biomarker Studies"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Shannon Stott (Massachusetts General Hospital and Harvard Medical School, United States)
"Microfluidics for Cell-Specific EV Isolation in Cancer"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Juan Falcon-Perez (CIC bioGUNE, Spain)
"From the EV-Omics Era to Single-Vesicle Analysis: Starting the EV Puzzle Game"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Role of Endogenous EVs in Driving Disease Pathology
Discussion Leader: David Lyden (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Andrew Hill (La Trobe University, Australia)
"EVs and Protein Misfolding in Neurodegenerative Diseases"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lucia Languino (Thomas Jefferson University, United States)
"Small Extracellular Vesicle Reprogramming of Cancer Cells and the Tumor Microenvironment"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Dolores Di Vizio (Cedars-Sinai Medical Center, United States)
"Heterogeneous Induction of Interferon Pathway in the Tumor Microenvironment by Different Populations of Cancer-Derived Extracellular Vesicles"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Frederik Verweij (Div. of Cell Biology, Neurobiology & Biophysics, Utrecht University)
"Exploiting CD63-Based Reporter Systems to Image EV Release in Vitro and in Vivo"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
EVs as Delivery Vehicles for Drugs and RNAs
Discussion Leader: Andrew Hill (La Trobe University, Australia)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Pieter Vader (University Medical Center Utrecht, The Netherlands)
"Extracellular Vesicle-mediated RNA Delivery: from Mechanistic Insights towards Therapeutic Applications"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Charles Lai (Academia Sinica, Taiwan, Taiwan)
"Dosage, Labeling, Size-Dependent Biodistribution, and Function of Extracellular Vesicles"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
EVs in Host-Pathogen Interactions
Discussion Leader: Esther Nolte-'t Hoen (Utrecht University, The Netherlands)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ana Torrecilhas (Federal University of Sao Paulo, Brazil)
"Extracellular Vesicles in Protozoan Parasite-Host Communication"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Arne Weiberg (LMU Munich, Germany)
"RNA Crosstalk and EVs in Plant-Pathogen Interaction"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Navneet Dhillon (University of Kansas Medical Center, United States)
"Lessons Learned from EVs and COVID-19 Pandemic: Mediators and Markers of the Disease"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic Applications of EVs
Discussion Leader: Jacqueline Bromberg (Memorial Sloan Kettering Cancer Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Adrian Morelli (University of Pittsburgh, United States)
"Graft-Derived Extracellular Vesicles as Initiators of the Anti-Donor Response in Transplantation"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Bharat Ramratnam (Brown University and Lifespan, United States)
"Engineering EVs to Reverse HIV Latency"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Stem Cell EVs for Regenerative Medicine
Discussion Leader: Anastasia Khvorova (University of Massachusetts Medical School, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Susmita Sahoo (Icahn School of Medicine at Mount Sinai, United States)
"Extracellular Vesicles and Cardiac Disease"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Sai Kiang Lim (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Mitigating Anticipated Risks in Manufacturing and Translating MSC-EVs for Regenerative Medicine"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Benedetta Bussolati (Università di Torino, Italy)
"Renal Repair: From Stem Cell to Biofluid EVs"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Ewa Zuba-Surma (Jagiellonian University, Krakow, Poland, Poland)
"Pluripotent Stem Cell-Derived EVs: Biological Properties and Perspectives on Use in Tissue Repair"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
EV Therapies: Concepts and Clinical Trials
Discussion Leader: Sai Kiang Lim (Institute of Molecular and Cell Biology, A*STAR, Singapore)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:05 pm
Maria Brizzi (University of Turin, Italy)
"Autologous Serum-Derived EVs to Treat Venous Trophic Lesions not Responsive to Conventional Treatments"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:35 pm
Eva Rohde (Paracelsus Medical University and SALK, Austria)
"Regulatory Needs for the Clinical Evaluation of Stromal Cell-derived Native EV-Therapeutics"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure