| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
| 7:40 pm - 7:50 pm | Welcome by meeting Chair |
| 7:50 pm - 9:30 pm | Structure of integrins and associated molecules |
| Discussion Leader: Jari Ylanne (University of Jyvaskyla, Finland) |
| 7:50 pm - 8:20 pm | Tim Springer (Harvard, USA)
"Integrins, Latent TGF-β, Force, and Allostery" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:00 pm | Dorit Hanein (Sanford-Burnham, USA)
"3D Structure of Full-Length Integrin in a Membrane Bilayer" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Junichi Takagi (Osaka University, Japan)
"Testing the 'switchblade' activation model for β1 integrins using electron microscopy" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Integrin Activation |
| Discussion Leader: Cary Wu (University of Pittsburgh, USA) |
| 9:00 am - 9:30 am | Mark Ginsberg (UC San Diego, USA)
"Tilting the Balance of Integrin Activation" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Robert Gilbert (Oxford, UK)
"Cryo-EM and small-angle neutron scattering used in combination to study integrin binding and activation by fibronectin and talin" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 11:00 am | Ed Plow (Cleveland Clinic, USA)
"Integrin activation mechanisms" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Johanna Ivaska (VTT Medical Biotechnology and University of Turku, Finland)
"β1-integrin inactivation in vitro and in vivo" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Tobias Ulmer (University of Southern California, USA)
"Structural determinants of integrin transmembrane association: critical elements of inflammation, atherothrombosis, and tumor metastasis" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Tom Bunch (University of Arizona, USA)
"Integrins Gone Wild!!! Inappropriately Turned On Integrins Discovered as Conditionally Lethal Mutations" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Signaling Through Integrins |
| Discussion Leader: Sue LaFlamme (Center for Cell Biology and Cancer Research, Albany Medical Center, USA) |
| 5:30 pm - 6:00 pm | Jun Qin (Cleveland Clinic, USA)
"Structural diversity of integrin inner face in regulating integrin signaling" |
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Mike DiPersio (Center for Cell Biology & Cancer Research, Albany Medical College, USA)
"α3/β1-dependent mRNA processing of pro-angiogenic/pro-tumorigenic genes" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:00 pm | Tony Koleske (Yale University, USA)
"Regulation of synapse and dendrite stability by integrin:Arg interactions" |
| 7:00 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Etienne Boulter (INSERM AVENIR U634, University of Nice Sophia Antipolis, France)
"Regulation of epidermal homeostasis and wound repair by CD98hc" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Adhesion site assembly and dynamics |
| Discussion Leader: Arnoud Sonnenberg (NKI, The Netherlands) |
| 9:00 am - 9:30 am | Ken Yamada (NIH/NIDCR, USA)
"Cell adhesions and migration in 3D" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Staffan Strömblad (Karolinska Institutet, Sweden)
"'Atypical' adhesion complexes with a potential role in mitosis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Benny Geiger (Weismann Inst, Israel)
"Functional modules within the integrin adhesome, regulating matrix recognition and sensing" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Olivier Rossier (Institut Interdisciplinaire de Neuroscience, Bordeaux, France)
"The inner life of adhesion sites: Integrin dynamics at the nano-scale" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Martin Humphries (University of Manchester, UK)
"Insights from mass spectrometric analyses of adhesion signalling" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Sara Wickstrom (Max Planck Institute for Biology of Ageing, Cologne, Germany)
"Mechanisms of adhesion turnover during cell migration" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Cell migration |
| Discussion Leader: Bernhard Wehrle-Haller (University of Geneva, Medical School, Switzerland) |
| 5:30 pm - 6:00 pm | Anna Huttenlocher (University of Wisconsin, Madison, USA)
"Imaging leukocyte migration in vivo: implications to human disease" |
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:40 pm | Michael Sixt (Institute of Science and Technology, Austria)
"Mechanics of Leukocyte Locomotion" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:20 pm | Peter Friedl (Radboud University, Nijmegen, The Netherlands)
"Integrin-dependent and -independent cell migration" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cytoskeletal Dynamics |
| Discussion Leader: Ellen Van Obberghen-Schilling (University of Nice-Sophia Antipolis, France) |
| 9:00 am - 9:30 am | Frank Gertler (MIT, USA) |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Maddy Parsons (King's College London, UK)
"Regulation of fibroblast chemotaxis by β1 integrins" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Vic Small (IMBA, Austria)
"Pushing with actin in cell migration" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Yoshiko Inoue (Wellcome Trust / Cancer Research UK Gurdon Institute, University of Cambridge, UK)
"Building a complex protein network linking the membrane to the cytoskeleton: impact of gene dosage on protein stoichiometry within the integrin adhesion complex in vivo" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Erik H.J. Danen (Leiden University, Leiden NL)
"Integrin regulation of cell migration and metastasis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | John Lamar (M.I.T., USA)
"Multiplex in vivo RNAi Screens for Investigating the Roles of Integrins During Metastasis" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Ivan de Curtis (University Vita-Salute and San Raffaele Scientific Institute, Italy)
"Liprin-α1: an old protein with new regulatory functions in cell motility and invasion" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Mechano-sensing and mechano-signaling |
| Discussion Leader: Viola Vogel (ETH, Zurich, Switzerland) |
| 5:30 pm - 6:00 pm | Martin Schwartz (Yale University, USA)
"Integrin signaling and mechanotransduction" |
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Michel Labouesse (IGBMC, France)
"Mechanotransduction through hemidesmosomes" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:00 pm | Mike Sheetz (Columbia University, USA)
"Rigidity Sensing by Local Contraction and Adhesion Signaling by Repeated Stretching" |
| 7:00 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Igor Barsukov (University of Liverpool, UK)
"Domain structure of the talin rod: designed to bind vinculin in response to force?" |
| 7:25 pm - 7:30 pm | Discussion |
| 7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Integrins in in vivo and disease models |
| Discussion Leader: Richard Hynes (MIT, USA) |
| 9:00 am - 9:30 am | Reinhard Faessler (Max Planck Institute of Biochemistry, Germany)
"Genetic analysis of integrin signalling in mice" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Magdalena Chrzanowska-Wodnicka (BloodCenter of Wisconsin, USA)
"Small G protein Rap1 promotes VEGF-mediated angiogenesis through integrin αVβ3" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Kairbaan Hodivala-Dilke (Barts Cancer Institute, Queen Mary University of London, UK)
"Understanding the role of adhesion related molecules in tumour angiogenesis" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Bernhard Nieswandt (University of Würzburg, Germany)
"Regulation of platelet integrins - novel aspects" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Simon Goodman (Merck KGaA, Germany)
"Integrins as clinical targets: dreams, nightmares and inceptions" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Matrix assembly and remodeling |
| Discussion Leader: Jane Sottile (University of Rochester School of Medicine & Dentistry, USA) |
| 5:30 pm - 6:00 pm | Jean Schwarzbauer (Princeton University, USA)
"The Role of Fibronectin Matrix Assembly in Stem Cell Differentiation" |
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:40 pm | Corinne Albiges-Rizo (Institut Albert Bonniot, France)
"Integrin dependent extracellular matrix remodeling in vascular integrity" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:20 pm | Val Weaver (UC San Francisco)
"Intrinsic and Extrinsic forces regulate tumor phenotype" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |