Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Making Sense of Focal Adhesions
7:40 pm - 8:20 pm
"Genetics and Cell Biology of Focal Adhesion Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Nanoscale Architecture of the Integrin-Based Adhesion Complexes and Cortical Actin Cytoskeleton in Embryonic Stem Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"In Vivo Adhesive Structures in Drosophila to Gain Insight into the Function of Adhesion Components"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrin Binding Proteins
9:00 am - 9:20 am
"Kindlin's Structure and Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Integrin Bidirectional Signaling by Distinct Modular Interactions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Force Tuning Through Regulation of Clathrin-Dependent Integrin Endocytosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Distinct Adhesion Complexes and Integrin Associated Proteins"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Unraveling the Mechanisms Enabling ECM Sensing at Filopodia Tips"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Fever Promotes T-Cell Trafficking via a Thermal Sensory Hsp90-α4 Integrin Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Inflammation and Homeostasis
6:00 pm - 6:20 pm
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Integrin Signaling Regulates Insulin-Stimulated Metabolism"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Role of Integrins in Regulatory T Cell Biology"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Biomechanical Regulation of Morphogenesis and Tissue Homeostasis by Cell-Matrix Adhesion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms and Mechanics of Integrin ECM Connections
9:00 am - 9:20 am
"Structural Characterization of Integrins by Single-Particle EM"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Exploring How Fibronectin-Binding Integrins upon Initiating Adhesion Sense Mechanical Load and Signal Other Integrins to Strengthen Cell Adhesion"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Leukocyte Integrin Activation Reduces Tumor Progression by Reprogramming Tumor-Associated Macrophages and Is a Novel Therapeutic Strategy"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Tuning Force Transduction in Amoeboid Migration"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Exploring the Substrate Dependence of Integrin-Mediated Mechanotransduction"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Integrins Control Basal-Cell Positioning and YAP Activity at Tumor Margins to Initiate Invasion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Alpha(v) Integrins and Autophagy Proteins Regulate Immune Signaling Through Intracellular Trafficking Event"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Integrin Delivery and Adhesion Structures
6:00 pm - 6:20 pm
"Mechanistic Details of Integrin and Other Cell Adhesion Molecules Trafficking Through the Endo-Lysosomal Network"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Frustrated Endocytosis in Cell Migration and Mechanotransduction"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Structural Biology of Cell Shape Formation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"The Nuclear Import Machinery Captures Endosomes to Drive Depletion of Nuclear G-Actin and SRF/MRTF Gene Expression"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Control of Vascular Permeability via β1-Integrin"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Integrin Associated Proteins Regulate Metastatic Dissemination Through Alterations to the Tumor Microenvironment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural Mechanism of Laminin Recognition by Integrins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Extracellular Matrix Components HAPLN1, Lumican and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Matrix Microenvironment Mediated Drug Resistance in Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"The Multifaceted Functions of Fibronectin in Tumor Tissue"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Extracellular Matrix Mechanical Cues Regulate Lipid Metabolism Through Lipin-1 and SREBP"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Biochemical Elucidation of the Bipartite Binding Site of Laminin for Integrins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Tools and Models for Deciphering Forces
6:00 pm - 6:20 pm
"Probes for Integrin Force Imaging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mechanotransduction and Mechanoadaptation at the Nucleocytoskeletal Interface"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Deciphering the Talin Code Using Structural Mechanobiology"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Force-Independent Association of the Mechanosensors Talin and Vinculin"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Rap1 Binding and a Lipid-Dependent Helix in Talin F1 Domain Promote Integrin Activation in Tandem"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Integrating Force and Function
9:00 am - 9:20 am
"Cell-Basement Membrane Interactions During Collective Cell Migration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanical Communication Between Cells and the Matrix"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Fibronectin-Mediated Inter-Tissue Adhesion Predisposes the Neural Tube to Spina Bifida"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Definition of the Adhesome by Proximity Biotinylation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Mechanobiology of Extracellular Matrix in Healthy and Diseased Tissues"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"αv-Class Integrins Mediate Cell Adhesion to Fibronectin Exclusively Through Binding to the RGD Motif"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Microtubule Function in the Mechanosensitive Regulation of Cell Migration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: New Molecules in Adhesion Dynamics
6:00 pm - 6:40 pm
"A Novel Milieu Molecule for TGF-β Required for Microglia Function"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Integrin α3β1 Regulates the Keratinocyte Secretome and Promotes Epidermal Tumor Growth Through Paracrine Stimulation of the Tumor Microenvironment"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Activation of Integrins by Ligands Through Binding to an Allosteric Site"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Integrin Dynamics and Adhesion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure