Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanobiology From Molecules to Cells
Discussion Leader: Mark Ginsberg (University of California, San Diego, United States)
7:40 pm - 8:20 pm
Michael Sheetz (University of Texas Medical Branch, United States)
"Tumor Cells Lack Rigidity Sensors and Are Mechanosensitive"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Alessandra Cambi (Radboud University Medical Center, The Netherlands)
"Mech(n)anobiology of Dendritic Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Erik Sahai (The Francis Crick Institute, United Kingdom)
"How Cancers Exploit Mechanical Weakness in the Stroma"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Using Integrin Structure to Devise Therapeutic Interventions
Discussion Leader: Bernhard Wehrle-Haller (University of Geneva, Switzerland)
9:00 am - 9:20 am
Tina Izard (The Scripps Research Institute, United States)
"New Structural Insights into Integrin Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
M. Amin Arnaout (Massachusetts General Hospital/ Harvard Medical School, United States)
"Structure-Guided Design of Novel Integrin Antagonists"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jing Li (Boston Children's Hospital, United States)
"Single Molecule FRET Measurement Reveals Integrin Activation Trajectory"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Melody Campbell (Fred Hutchinson Cancer Center, United States)
"Understanding Integrin Therapeutics Using cryoEM"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Hoa Nguyen (Arizona State University, United States)
"Pleiotrophin's Interaction With aM I Domain is Activation State Dependent"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Nicole Mattson (City of Hope, United States)
"Identification of a Lead Compound to Disrupt the Heterodimer Stability of ITGAV and ITGB5"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Imaging Dynamics of Cell-ECM interaction and Signaling
Discussion Leader: Guy Tanentzapf (University of British Columbia, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gaudenz Danuser (UT Southwestern Medical Center, United States)
"Substitute Fascin for Fbronectin – Anchorage-Independent Assembly of Adhesion-like Structures Promoting Proliferation Signals in Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Thomas Lecuit (IBDM, Aix-Marseille Université / CNRS / College de France, France)
"Geometric and Mechanical Constraints on Tissue Morphogenesis by the Extracellular Matrix"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Sarah Keary (ICFO - The Institute of Photonic Sciences, Spain)
"Differential Activation and Mesoscale Organization of Integrin Nanoclusters in Focal Adhesions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Scott Holley (Yale University, United States)
"The Molecular Dynamics of Single Integrin a5ß1 Heterodimers in Living Zebrafish Embryos"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Wenjun Deng (University of British Columbia, Canada)
"Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tools and Approaches to Study Mechanotransduction
Discussion Leader: Andres Garcia (Georgia Institute of Technology, United States)
9:00 am - 9:20 am
Brent Hoffman (Duke University, United States)
"Identifying Context-specific, Tension-dependent Protein Complexes Within Focal Adhesions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Thomas Barker (University of Virginia, United States)
"Probing the Mechanobiology of Wound Healing and Disease: Tools to Detect and Manipulate Fibronectin-integrin Interactions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Matthew Jones (University of Plymouth, United Kingdom)
"Cell-matrix Adhesion and the Cell-cycle"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Guillaume Charras (University College London, United Kingdom)
"The Mechanics of Epithelial Monolayers: Buckling, Curling, and Tearing"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Gregory Alushin (The Rockefeller University, United States)
"Visualizing Mechanotransduction through Actin Filaments"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Elijah Holland (Georgia Institute of Technology, United States)
"The Interplay Among Force, Focal Adhesions, and YAP"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Haguy Wolfenson (Technion - Israel Institute of Technology, Israel)
"YAP/Rigidity and Apoptosis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane and Receptor Trafficking
Discussion Leader: Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:50 pm
Johanna Ivaska (University of Turku, Finland)
"Turning over Active and Delivering New - Integrin Traffic and Cell Migration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Robert Coffey (Vanderbilt University Medical Center, United States)
"Extracellular Vesicles: What Does Membrane Trafficking Have to do with It"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Giorgio Scita (IFOM, the FIRC Institute of Molecular Oncology, Italy)
"Tissue Fluidification in Breast Cancer Progression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Michalis Gounis (CRUK Beatson Institute, United Kingdom)
"Altered Metabolism Coordinates Small Extracellular Vesicle Production and Invasive Behavior During Metastatic Seeding of Breast Cancer"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Amelia Meecham (UCSD, United States)
"Dissecting avß6 Internalization and Trafficking"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Matrix Receptors in Fibrosis and Disease
Discussion Leader: David Wasserman (Vanderbilt University, United States)
9:00 am - 9:20 am
Alexandra Naba (University of Illinois at Chicago, United States)
"SNED1: a Novel ECM Protein at the Intersection of Cancer and Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Roy Zent (Vanderbilt University Medical Center, United States)
"Integrin Signaling in Epithelial Cell Injury and Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Gema Bolas Gonzalez-Lliberos (Vanderbilt Univ Medical Ctr (MCN), United States)
"The Collagen Receptor Discoidin Domain Receptor 1 Regulates Mitochondrial Oxidative Stress in Kidney Injury"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
David Cheresh (University of California, San Diego, United States)
"Cancer Cell Response to Isolation Stress Leads to Secretion of a Fibronectin-enriched Niche that Supports Tumor Initiation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Rachel Lennon (Wellcome Centre for Cell-Matrix Research, United Kingdom)
"Interrogating Basement Membrane Regulation and Dynamics in the Kidney"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Coert Margadant (Institute of Biology/Leiden University, The Netherlands)
"Pregnancy-associated Maternal Antibodies Against ß3 Integrins Cause Endothelial Cell Damage and Disrupt Sprouting Angiogenesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Catherine Costello (Boston University Chobanian & Avedisian School of Medicine, United States)
"Influence of JAK2V617F Mutation on the N-glycosylation Profile of a2 and ß1 Integrins in the Megakaryocyte and Platelet Lineages"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Matrix Receptors in Host-Tumor Interaction
Discussion Leader: Ellen Van Obberghen-Schilling (Université Côte d'Azur, France)
7:30 pm - 7:50 pm
Kairbaan Hodivala-Dilke (Barts Cancer Institute, United Kingdom)
"Blood Vessel Control of Cancer Cells – New Ways for Old Roads"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Elena Rainero (The University of Sheffield, United Kingdom)
"The Extracellular Matrix Supports Cancer Cell Growth Under Amino Acid Starvation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Janine Erler (BRIC, University of Copenhagen, Denmark)
"Targeting the Metastatic Niche"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Stephen Nishimura (University of California, San Francisco, United States)
"Integrin-Mediated TGF-Beta Activation in Tumor Immune Evasion"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cell-ECM Receptors in Cancer Cell Migration and Invasion
Discussion Leader: Corinne Albiges-Rizo (Institute for Advanced Biosciences, Université Grenoble / CNRS, INSERM, France)
9:00 am - 9:20 am
Maddy Parsons (King's College London, United Kingdom)
"Mechanosensitive Actin Dynamics in Cancer Cell Invasion"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Laura Machesky (CRUK Beatson Institute, University of Glasgow, United Kingdom)
"Mechanosensing Governs Metabolism and Metastasis of Pancreatic Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Michael DiPersio (Albany Medical College, United States)
"Integrin a3ß1 Regulates the Tumor Cell Secretome to Promote a Pro-Tumorigenic Microenvironment"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
David Schlaepfer (UC San Diego, United States)
"FAK and Extracellular Matrix – Making Connections in Ovarian Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Yekaterina Miroshnikova (NIH, United States)
"Extracellular Matrix Mechanics Regulates Stem Cell Fate by Altering Nuclear Architecture"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Staffan Strömblad (Karolinska Institutet, Sweden)
"Mechanical Regulation of Mevalonate Pathway Enzyme Synthesis via Integrin and Rac1 Signaling"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Emmanuel Dornier (Gustave Roussy institute, France)
"Collective Amoeboid Migration: How to Move With Integrins but no Extracellular Matrix"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Fibronectin From Structure to Function
Discussion Leader: Thomas Barker (University of Virginia, United States)
7:30 pm - 8:10 pm
Jean Schwarzbauer (Princeton University, United States)
"The Not-so-Simple Process of Fibronectin Matrix Assembly"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Christoph Ballestrem (University of Manchester, United Kingdom)
"Tensin3 Interaction With Talin Drives the Formation of Fibronectin-Associated Fibrillar Adhesions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Francesco Baschieri (INSERM, France)
"Fibroblasts Deposit Membranous Tracks That Steer Cancer Cell Migration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Martin Schwartz (Yale School of Medicine, United States)
"Mechanosenssing and matrix homeostasis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure