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Fibronectin, Integrins and Related Molecules

Gordon Research Conference

Studying Cell-Matrix Adhesion at Diverse Scales

May 4 - 9, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Venue

Office Manager: D'Angelina Mbalire

Office Manager Email: renaissancetuscany_sm@grc.org

Office Phone: +3905837691

Application Information

The application deadline for this meeting was April 6, 2025. You may still submit an application, which may be considered by the conference chair if there is still room available.

Conference Description

The Fibronectin, Integrins and Related Molecules GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held on May 4–9 at the Renaissance Tuscany Il Ciocco, Italy. This is the foremost international conference for academic, government and industry scientists interested in understanding how integrins and related adhesion receptors act in combination with the extracellular matrix to regulate many aspects of cell and tissue function. The program spans fundamental areas of biology - cell and developmental biology, tissue engineering, the etiology of disease, structural biology, mechanobiology, system biology, cancer research, and immunology. The theme of the 2025 year's meeting will be "from molecules to the whole organism". Sessions will represent the interdisciplinary nature of the integrin and extracellular matrix field: cutting edge imaging, structural biology and structure-function analysis of integrins and their associated molecules, cytoskeletal and adhesion dynamics, cell migration, model organism research, cancer and inflammation, protein trafficking and membrane dynamics, mechanobiology, cell signaling, Cell-Matrix adhesion in tissue morphogenesis, stem cell biology, organoids, and tissue engineering.

The conference will highlight exciting unpublished data and stimulate active discussion among all participants. To complement the program of invited speakers, the conference will include 10-15 short talks selected from abstracts and four poster sessions. Graduate students and postdoctoral fellows are encouraged to apply to the associated Gordon Research Seminar (GRS) which precedes the GRC.

Related Meeting

This GRC will be held in conjunction with the "Fibronectin, Integrins and Related Molecules" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Cell-ECM Adhesion From Structure and Function Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:15 pm	"Global Responses to Extracellular Rigidity in Pancreatic Cancer"
8:15 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"β1 Integrin–FAK–Piezo1 Signaling Axis Drives In-Situ Stiffening Mediated ECM Remodeling and Invasion of 3D Breast Epithelium"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Human Gut-Lymphoid Microphysiological System to Model Immune Responses"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Study of Integrin Structure Discussion Leader:
9:00 am - 9:20 am	"In Vitro Structural Reconstitution of Focal Adhesion Complexes"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Three Cryo-EM Structures of the Complement C3d-aMß2 Complex Reveal a Novel Layer of Dynamics and Universal Signaling Mechanism in Ligand Bound Integrin Receptors"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Ligand Binding Initiates Single-Molecule Integrin Conformational Activation"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Mechanical Control of Enzymatic Processes via Talin"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Mechanosensitive Integrins: Structural Dynamics and Cellular Adaptation to External Stiffness"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Diverging Evolutionary Trajectories of the Integrin αI Domain"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Luminescent Sensing of Conformational Integrin Activation in Living Cells"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Structural Insights into Integrins Mediating Cell Rolling and Adhesion: Dissecting the Underlying Mechanism"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:20 pm	General Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Mechanobiology: Molecules and Cells Discussion Leader:
6:00 pm - 6:20 pm	"LIM Domain Proteins Recognize Strained Actin in Adhesions"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"αV-Class Integrins Identify ECM-Context to License Cellular Mechanics and Mechanotransduction Within Seconds"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"The Impact of ECM Viscoelasticity on Tissue Organization and Dynamics"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin β6"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"The Role of Rnd3 in Nuclear Force Feedback as a Regulator of Actomyosin Tension"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	ECM in Tissue Development and Fibrosis Discussion Leader:
9:00 am - 9:20 am	"Piezo-Dependent Surveillance of Matrix Stiffness Generates Transient Cells that Repair the Basement Membrane"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Selective Inhibition of Matrix Mechanosensing in Stromal Cells Attenuates Cardiovascular Fibrosis"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Collagen- and RGD-Binding Integrins Mark Diseased Fibroblasts in Keloids and are TGF-ß1 Targets in Dermal Fibroblasts"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Dynamic Regulation of ECM Stability During Drosophila Development"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Collagen Binding Receptors Regulate Mitochondrial Function in Kidney Injury"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Fibrosis Inhibition Via Control Over Fibronectin Fibrillogenesis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"The Role of Fibronectin Remodelling in the Most Incipient Stages of Oesophageal Tumour Persistence"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Disease-Causing Maternal Antibodies Against ß3-Integrins Inhibit Integrin Activation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Cell-ECM Based Regulation of Regeneration and Tissue Homeostasis Discussion Leader:
6:00 pm - 6:20 pm	"Extracellular Matrix Regulates the Post-Injury Switch Between Fibrosis and Regeneration"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Basement Membrane lama3 Regulates Epithelial Cell Renewal in the Gut"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Epithelial Stem Cell-Matrix Interactions Confer Mechanical Resilience to the Peridermal Tissue"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Cellular Choreography: How Cell Motility Guides Extracellular Matrix Remodelling and Tissue Expansion During Early Avian Development"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Reciprocal Regulation Between Mitochondria and Focal Adhesions Governs Cell Migration"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Developmentally Regulated Changes in Basement Membrane Composition Affect Matrix Viscoelasticity and Tissue Morphogenesis"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Integrins, ECM and Cancer Discussion Leader:
9:00 am - 9:20 am	"Translation of Secretory mRNAs must Be Restrained During Early Oncogenesis to Enable α5β1-Integrin Mediated Generation of Fibronectin-Rich Tumour Initiation Niches"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Arf6-Dependent Endocytic Recycling Regulates Extracellular Matrix Assembly by Cancer Associated Fibroblasts to Promote Ovarian Cancer Cell Invasion"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Studying the Mechanisms of Intravascular Adhesion and Extravasation of Pancreatic Cancer Cells"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Understanding 3D Cell Motility in Low-Viscosity Matrix"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"MET Endosomal Signalling and Cancer Cell Invasion"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Amino Acid Starvation Drives Cancer Invasiveness via RAS/MAPK-Dependent Up-Regulation of α2β1 Integrin"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Tumour-Derived Laminin α5 is Essential for Luminal Breast Cancer Initiation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Understanding Breast Cancer Risk Associated With Extracellular Matrix Composition"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Mechanical Imprinting of the Talin Interaction with DLC1 Regulates RhoA Activity and Cardiomyocyte Remodelling."
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Cell-ECM Adhesion in the Immune System Discussion Leader:
6:00 pm - 6:20 pm	"Aging of Bone and Bone Marrow Microenvironment: A Human Perspective"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Integrin α6-Laminin Interactions Allow Diverse Malignancies to Metastasize From Bone Marrow to CNS Meninges"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Adhesive Migration Strategies in the Immune Cell World"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:35 pm	"Tension-Sensing Membrane Domains in Mechanoadaption and Mechanotransduction"
7:35 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Uridine Phosphorylase-1 Supports Metastasis of Mammary Cancer by Altering Immune and Extracellular Matrix Landscapes of the Lung"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Imaging Cell-ECM Adhesion Discussion Leader:
9:00 am - 9:20 am	"On the Role of Talin as an Evolutionary Conserved Regulator of Cell Adhesion"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Flow Induced Endothelial Planar Polarity for Signaling Regulation"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"An Optogenetic Toolbox for Spatial-Temporal Manipulation of Integrin Adhesion Complexes."
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Unveiling the Dynamic Nanoscale Landscape of Integrins and Regulators"
10:50 am - 11:00 am	Discussion
11:00 am - 11:10 am	"The Talin-Kindlin Ternary Complex Crosstalk Controls Kidney Morphogenesis Via Modulating Paxillin Phosphorylation in the Ureteric Bud"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Canonical and Non-Canonical Integrin-Based Adhesions Dynamically Interconvert"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"High-Throughput Automated Quantitative Analysis of Spatiotemporal Endothelial Cell Dynamics and Extracellular Matrix Remodeling During Sprouting Angiogenesis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"The Role of Extracellular Matrix Degradation During Drosophila Abdominal Epidermis Development"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Cardiomyocyte Mechanical Memory is Regulated Through the Talin Interactome and DLC1 Dependent Regulation of RhoA"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	The Dynamic World of Cell-ECM Adhesion Discussion Leader:
6:00 pm - 6:20 pm	"Deciphering the Regulatory Roles of Fibronectin in Mammary Epithelial Regeneration and Breast Cancer Progression"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Extracellular Matrix Microenvironment Collaborates With Cell Mechanics to Guide Early Embryonic Cell Fate Specification"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Lama5 is Necessary for Tumorigenesis in the Mouse Intestine"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Morphogenetic Control of Mouse Germline Entry"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Synthetic Scaffold for IPS Cell Expansion and Organoid Induction Modulated by Physical Properties and Adhesion Peptide Sequences"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Matrix Stiffness Modulates 3D Spheroid Sorting and Burst-Like Collective Migration"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

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Conference History Fibronectin, Integrins and Related Molecules (GRS) Contribute Financially to This Conference

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

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Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,610.00

Conferee Shared Room:

$1,325.00

Conferee Off-Site:

$915.00

Guest Single Room:

$1,420.00

Guest Shared Room:

$1,135.00

Guest Off-Site:

$725.00

Child 4-12 yrs Shared Room:

$568.00

Child 4-12 yrs Off-Site:

$363.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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