Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Cell-ECM Adhesion From Structure and Function
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Global Responses to Extracellular Rigidity in Pancreatic Cancer"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"β1 Integrin–FAK–Piezo1 Signaling Axis Drives In-Situ Stiffening Mediated ECM Remodeling and Invasion of 3D Breast Epithelium"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Human Gut-Lymphoid Microphysiological System to Model Immune Responses"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Study of Integrin Structure
9:00 am - 9:20 am
"Tracing the Evolutionary Origin and Structural Ligand Mimicry of the Integrin Inserted Domain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Three Cryo-EM Structures of the Complement C3d-aMß2 Complex Reveal a Novel Layer of Dynamics and Universal Signaling Mechanism in Ligand Bound Integrin Receptors"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Ligand Binding Initiates Single-Molecule Integrin Conformational Activation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Mechanical Control of Enzymatic Processes via Talin"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Mechanosensitive Integrins: Structural Dynamics and Cellular Adaptation to External Stiffness"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Diverging Evolutionary Trajectories of the Integrin αI Domain"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Poster Previews
11:55 am - 12:05 pm
"Luminescent Sensing of Conformational Integrin Activation in Living Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Structural Insights into Integrins Mediating Cell Rolling and Adhesion: Dissecting the Underlying Mechanism"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanobiology: Molecules and Cells
6:00 pm - 6:20 pm
"LIM Domain Proteins Recognize Strained Actin in Adhesions"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"αV-Class Integrins Identify ECM-Context to License Cellular Mechanics and Mechanotransduction Within Seconds"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Impact of ECM Viscoelasticity on Tissue Organization and Dynamics"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin β6"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"The Role of Rnd3 in Nuclear Force Feedback as a Regulator of Actomyosin Tension"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
ECM in Tissue Development and Fibrosis
9:00 am - 9:20 am
"Piezo-Dependent Surveillance of Matrix Stiffness Generates Transient Cells that Repair the Basement Membrane"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Selective Inhibition of Matrix Mechanosensing in Stromal Cells Attenuates Cardiovascular Fibrosis"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Collagen- and RGD-Binding Integrins Mark Diseased Fibroblasts in Keloids and are TGF-ß1 Targets in Dermal Fibroblasts"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dynamic Regulation of ECM Stability During Drosophila Development"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Fibrosis Inhibition Via Control Over Fibronectin Fibrillogenesis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"The Role of Fibronectin Remodelling in the Most Incipient Stages of Oesophageal Tumour Persistence"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Disease-Causing Maternal Antibodies Against ß3-Integrins Inhibit Integrin Activation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mitochondrial Mechanotransduction Coordinates the Metabolic and Transcriptional Response to Forces"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell-ECM Based Regulation of Regeneration and Tissue Homeostasis
6:00 pm - 6:20 pm
"Extracellular Matrix Regulates the Post-Injury Switch Between Fibrosis and Regeneration"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Basement Membrane lama3 Regulates Epithelial Cell Renewal in the Gut"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Epithelial Stem Cell-Matrix Interactions Confer Mechanical Resilience to the Peridermal Tissue"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Cellular Choreography: How Cell Motility Guides Extracellular Matrix Remodelling and Tissue Expansion During Early Avian Development"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Reciprocal Regulation Between Mitochondria and Focal Adhesions Governs Cell Migration"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Developmentally Regulated Changes in Basement Membrane Composition Affect Matrix Viscoelasticity and Tissue Morphogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrins, ECM and Cancer
9:00 am - 9:20 am
"Translation of Secretory mRNAs must Be Restrained During Early Oncogenesis to Enable α5β1-Integrin Mediated Generation of Fibronectin-Rich Tumour Initiation Niches"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Arf6-Dependent Endocytic Recycling Regulates Extracellular Matrix Assembly by Cancer Associated Fibroblasts to Promote Ovarian Cancer Cell Invasion"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Studying the Mechanisms of Intravascular Adhesion and Extravasation of Pancreatic Cancer Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Understanding 3D Cell Motility in Low-Viscosity Matrix"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"MET Endosomal Signalling and Cancer Cell Invasion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Amino Acid Starvation Drives Cancer Invasiveness via RAS/MAPK-Dependent Up-Regulation of α2β1 Integrin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Tumour-Derived Laminin α5 is Essential for Luminal Breast Cancer Initiation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Understanding Breast Cancer Risk Associated With Extracellular Matrix Composition"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanical Imprinting of the Talin Interaction with DLC1 Regulates RhoA Activity and Cardiomyocyte Remodelling."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell-ECM Adhesion in the Immune System
6:00 pm - 6:20 pm
"Aging of Bone and Bone Marrow Microenvironment: A Human Perspective"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Integrin α6-Laminin Interactions Allow Diverse Malignancies to Metastasize From Bone Marrow to CNS Meninges"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Adhesive Migration Strategies in the Immune Cell World"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Tension-Sensing Membrane Domains in Mechanoadaption and Mechanotransduction"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Uridine Phosphorylase-1 Supports Metastasis of Mammary Cancer by Altering Immune and Extracellular Matrix Landscapes of the Lung"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Imaging Cell-ECM Adhesion
9:00 am - 9:20 am
"On the Role of Talin as an Evolutionary Conserved Regulator of Cell Adhesion"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Flow Induced Endothelial Planar Polarity for Signaling Regulation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"An Optogenetic Toolbox for Spatial-Temporal Manipulation of Integrin Adhesion Complexes."
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Unveiling the Dynamic Nanoscale Landscape of Integrins and Regulators"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
"The Talin-Kindlin Ternary Complex Crosstalk Controls Kidney Morphogenesis Via Modulating Paxillin Phosphorylation in the Ureteric Bud"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Canonical and Non-Canonical Integrin-Based Adhesions Dynamically Interconvert"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"High-Throughput Automated Quantitative Analysis of Spatiotemporal Endothelial Cell Dynamics and Extracellular Matrix Remodeling During Sprouting Angiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Role of Extracellular Matrix Degradation During Drosophila Abdominal Epidermis Development"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Cardiomyocyte Mechanical Memory is Regulated Through the Talin Interactome and DLC1 Dependent Regulation of RhoA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Dynamic World of Cell-ECM Adhesion
6:00 pm - 6:20 pm
"Deciphering the Regulatory Roles of Fibronectin in Mammary Epithelial Regeneration and Breast Cancer Progression"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Extracellular Matrix Microenvironment Collaborates With Cell Mechanics to Guide Early Embryonic Cell Fate Specification"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Lama5 is Necessary for Tumorigenesis in the Mouse Intestine"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Morphogenetic Control of Mouse Germline Entry"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Synthetic Scaffold for IPS Cell Expansion and Organoid Induction Modulated by Physical Properties and Adhesion Peptide Sequences"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Matrix Stiffness Modulates 3D Spheroid Sorting and Burst-Like Collective Migration"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure