Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Global Impact of Food Allergy
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:20 pm
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"NIAID's Strategic Approach to Food Allergy Research"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Alpha Gal in Rural African Subjects"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"The Five Ds of Food Allergy Prevention – Is There More to the Food Allergy Epidemic than Diet Alone"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Deciphering the Immunological, Molecular and Genetic Components of the Food Allergy Disorder Eosinophilic Esophagitis"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Food Allergy vs Tolerance: Understanding the Balance
9:00 am - 9:20 am
"Lessons We Have Learned from Early Childhood Exposure to Peanut"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Epidemiological Evidence for the Atopic March"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Optimizing Translation Research and Implementation of Best Practice of Care for Food Allergy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Prevention of Symptoms with Oral Immunotherapy: What Is the Dose Threshold?"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Microbiome and Changing Patterns of Food Allergies in Asia"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"The Role of Staphylococcus aureus in Food Allergy"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Mitochondrial Control of Immune Tolerance to Allergens"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Food Surveillance by the Immune System"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Induction of Neonatal Tolerance Through Breast Milk"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of T Cells in Food Allergy
7:30 pm - 7:45 pm
"Pre-Immune Influence of Gamma Delta T Cells on B Lymphocytes and Antibodies"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Deconvoluting Heterogeneity in the CD4+ T Cell Responses to Food Allergen"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mapping Epitope Targets of T Cells in Food Allergy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Investigation of Peanut-Specific T Effector and T Regulatory Cells in Children Allergic and Tolerant to Peanut"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Regulatory T Cells in Food Allergy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunological Mechanisms of Food Allergy: From Skin to Gut
9:00 am - 9:10 am
"In Pursuit of Immune Tolerance: Perspectives from the Immune Tolerance Network"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Practical Aspects of Early Peanut Introduction: Who Needs to Be Screened and How?"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Immune Regulation at Barrier Surfaces"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Regulation of Type-2 Immunity and Inflammation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Regulation of Allergic Responses to Food by Commensal Bacteria"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Innate Lymphoid Cell (ILC) Regulation of Host-Microbe Interactions"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Early Diet and Environment's Impact on Microbiome and the Development of Allergies"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Tissue Adaptation: Implications for Gut Immunity and Tolerance"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The Interplay Between the Gut Microbiota and Food Allergy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein and Peptide Chemistry Involved in Food Allergy
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Probing the Immune Response in Food Allergy Using CyTOF
7:45 pm - 7:55 pm
"Mapping Epitope Targets of T Cells in Food Allergy"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Highly Multiplexed Analysis of Resident and Inflammatory Immune Cell Populations Using Multiplexed Ion Beam Imaging"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Early Life Innate Immune Signatures of Persistent Food Allergy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Food Allergens: A Molecular Perspective"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Using Proteomics to Investigate Allergen Epithelial Transport and Subsequent Sensitization and Elicitation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mass Spectrometry to Complement Standardization of Complex Allergenic Extracts"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Role of 2S Albumins in Food Allergy"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of B Cells and Immunoglobulins in Food Allergy
9:00 am - 9:20 am
"Induction and Breaking of Allergen Tolerance, Role of T and B Regulatory Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Regulation of IgE B Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Can Specific IgE and IgG4 Responses Help to Explain the Increases in Food Allergy?"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Analysis of B Cell Repertoires in Peanut Allergy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Analysis of Antigen-Specific Repertoire in Relation to Peanut Allergy Phenotypes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Inhibition of IgE: Receptor Interactions and Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"IgG1 Memory Cells Keep the Memory of IgE Responses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Roles of IgE in Food Allergy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Inhibitors of Histamine Releasing Factor Mitigate Anaphylactic Symptoms of Food Allergy in the Mouse Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Roles of Basophils, Eosinophils, and Mast Cells in Food Allergy
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
"Deciphering the Roles of Mast Cells Versus Basophils in Food Allergy and Anaphylaxis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Terminating Mediator Release from Human Basophils and Mast Cells"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Novel Strategies to Prevent Mast Cell Activation in Anaphylaxis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Two Doses of Ibrutinib Abrogates Skin Test Responses and Basophil Activation in Food Allergic Adults"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"IL-4 Signaling and IL-9-Producing Mucosal Mast Cells in Food Allergy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Skin Mechanical Injury Promotes ILC2-Dependent Intestinal Mast Cell Expansion"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of the Epithelium in Allergic Disease
9:00 am - 9:20 am
"Role of Epithelial Barrier and Allergic Diseases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Intestinal Epithelial Allergen Sampling and Food Allergy"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Crosstalk Between Intestinal Stem Cells and Immune Cells Modulate Epithelial Cell Fate"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of IL-33 by Dectin-1"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Mechanisms of Sensitization and Tolerance to Foods Through the Skin"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"What a Rare Immunodeficiency Can Teach Us About the Immunological Mechanisms of Food Allergy"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Immune Dysregulation in Humans and Mice"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"How to Avoid Allergens? Characterizing the Neuroimmune Mechanisms of Food Aversion"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Features of CC027/GeniUnc, an Orally Reacting Peanut Allergy Model"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Adjuvant-Free Intragastric Sensitization to Peanut in CC027/GeniUnc Mice"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Phenotypes and Endotypes in Food Allergy
7:30 pm - 8:00 pm
"IL-13/IL-4 in Allergic Inflammatory Diseases"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Food Allergies: Phenotypes: IgE or Not? Endotypes: Anaphylaxis or Not?"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Molecular Allergology in Diagnosis, Treatment and Prevention of Food Allergy"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Mechanistic Clues to What Makes Oral Immunotherapy Work"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mucosal Immune Redirection in Food Allergy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure