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Fragile X and Autism-Related Disorders

Gordon Research Conference

Mechanistic Insights and Therapeutic Development for Fragile X and Neurodevelopmental Disorders

June 14 - 19, 2026

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

and

Jordan Hotel at Sunday River

27 Grand Circle

Newry, Maine, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by May 17, 2026. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Fragile X and Autism-Related Disorders GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Fragile X and Autism-Related Disorders" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Synaptic Plasticity, Receptors and Glia, in Neurodevelopmental Disorders Discussion Leader:
7:40 pm - 8:20 pm	"AMPA Receptors, SynGAP1 and Autism-Related Disorders"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"Role of Astrocytes in Neurodevelopmental Disorders"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Molecular and Cellular Mechanisms of Fragile X and Related Disorders Discussion Leader:
9:00 am - 9:25 am	"Synaptic Mechanisms of Sensory Neocortical Circuit Hyperexcitability in Mouse Autism Models"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Connectivity in Cerebral Cortex and Neurodev Disease"
10:00 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 11:05 am	"Somatosensory Circuits that Mediate our Sense of Touch"
11:05 am - 11:15 am	Discussion
11:15 am - 11:40 am	"Metformin for Treatment of Fragile-X and Phelan McDermid Syndromes"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Metformin for the Treatment of Individuals with Fragile X Syndrome"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cellular Diversity and Transcriptomics in ASD and NDs Embracing Complexity Discussion Leader:
7:30 pm - 7:55 pm	"Psychencode 2 Talk on ASD"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Thalamo Cortical Alteration in 22q11.2 and ASD"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Partitioning Rare Variant Burden by Pathway, Tissue and Cell Type Reveals Missing Heritability and Molecular Subtypes of Autism"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Model Systems of Fragile X and Neurodevelopmental Disorders Discussion Leader:
9:00 am - 9:25 am	"IGF2 in Memory, Neurodevelopmental Disorders"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Mitochondrial Dysfunction in Fragile X Syndrome Neurons"
10:00 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 10:55 am	Short Talk Selected from Poster Abstracts
10:55 am - 11:00 am	Discussion
11:00 am - 11:25 am	"FMR1 Mutant Marmosets Show Fragile X Syndrome Phenotypes"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	"A Primate Model for Fragile X Syndrome"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Body-Brain Axis Discussion Leader:
7:30 pm - 7:55 pm	"Programming the Developing Brain: Microbiota-Derived Functional Signals From Human Infants to Preclinical Models"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Elucidating the Role of the Gestational Gut Microbiome in Development and Function of the Somatosensory Circuit"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Dissecting Biological Mechanisms Underlying Behavioral Heterogeneity in Neurodevelopmental Disorders"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Organoids Assembloids and Functional Genomics Discussion Leader:
9:00 am - 9:25 am	"Extrinsic Inputs Driving Cell Fate Specification in the Developing Human Cortex"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Mechanisms Underlying ID and Autism iPSC and Organoids"
10:00 am - 10:10 am	Discussion
10:10 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Engineering Human Brain Organoids for Modeling Neurodevelopment and Neurological Disorders"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	"3D Cellular Models of Human Brain Development: Towards Novel Disease Biology and Therapeutic Avenue"
11:45 am - 11:55 am	Discussion
11:55 am - 12:20 pm	"Cortical Development and Neurodevelopmental Disease"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	AI and Foundational Models in Clinical Research and Basic Neurobiology Discussion Leader:
7:30 pm - 7:55 pm	"Machine Learning-Based Penetrance of Genetic Variants"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Spatial Genomics"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Prime Editing-Installed Suppressor tRNAs for Disease-Agnostic Genome Editing"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Gene Therapy Clinical Trials Discussion Leader:
9:00 am - 9:25 am	"Taisha Gene Therapy Rett Syndrome (TSHA-102 AAV)"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Antisense Oligonucleotides for Genetic Correction of Angelman Syndrome"
10:00 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 11:05 am	"Fragile X and Jordan’s Syndrome"
11:05 am - 11:15 am	Discussion
11:15 am - 11:40 am	"Antisense-Based Therapies for Rare Neurodevelopmental Disorders"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Leveraging EEG in Clinical Trials: Evidence from Metformin and Arbaclofen Trials in FXS and Autism"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Methodologies in Clinical Trials and N of One, N of Few Discussion Leader:
7:30 pm - 7:55 pm	"Patient-Customized Oligonucleotide Therapy for Rare Genetic Diseases"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"ASO Development for Schinzel Giedion Syndrome"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"ASO Therapies in Developmental and Epileptic Encephalopathies: Impact on Seizure and Non-Seizure Outcomes"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Fragile X and Autism-Related Disorders (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,755.00

Conferee Shared Room:

$1,375.00

Conferee Off-Site:

$985.00

Guest Single Room:

$1,535.00

Guest Shared Room:

$1,155.00

Guest Off-Site:

$765.00

Child 4-12 yrs Shared Room:

$578.00

Child 4-12 yrs Off-Site:

$383.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$65.00

Bus Departing:

$65.00

Additional Fee Info

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