Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: FTD and Related Dementias: Clinical Updates on Genetics, Neuropathology and Imaging
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Frontotemporal Dementia: Unraveling Mechanisms and Advancing Care"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"FTD: Overview of Genetics, Imaging and Basic Neuropathology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Unique and Shared Transcriptional Signatures across FTLD-TDP Subtypes: Insights from Single-Nucleus RNA Sequencing"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Distinct Somatic Genomic Alterations in Single Neurons in MAPT-Mutant Primary Tauopathy"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuroinflammation and Spread of Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Traps and Exit Strategies for Pathological Tau in the Cell"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Targeting Neuroimmune Interactions in FTD"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Tau Endo-Lysosomal Processing in Human iPSC-Derived Microglia Is Impacted by Tau Aggregation State, but Not by Microglial Activation Status"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Neurons Escape Dysfunction and Death Through Tunneling Nanotube Support by Microglia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Neuroinflammation in FTD: Mechanisms and Therapeutic Targets"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Dysregulated SIRT1–P53 Feedback Loop Defines a Common Pathogenic Mechanism in Sporadic and Familial ALS and FTD"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Molecule Imaging of Tau and FTD-Associated Tau Mutants in iPSC-Derived Neurons"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biomarkers and the Genotype-Phenotype Connection
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Biomarkers in Neurodegeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Enhanced Legumain Maturation and Expression Leads to TDP-43 Pathology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Translation of a Human iPSC-Derived Frontotemporal Dementia Organ-on-a-Chip Phenotypic Disease Model to Assess Biomarker Development and Inform Clinical Trials"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Progranulin C-Terminal Fragment Alters TDP43 Processing"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Progression of Volume and Shape Alterations in Deep Gray Matter in Frontotemporal Dementia"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosome Biology and Novel Mechanisms in FTD
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Lysosome Stress Pathways as Drivers of Neurodegeneration"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Genetic Drivers of Lysosomal Dysfunction in FTLD-Tau"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Phospho-Proteome Profiling in Human Neurons Reveals Targets of TBK1 in ALS/FTD-Associated Autophagy Networks"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lysosomal Lipid Degradation and Neurodegeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Isoform-Specific Effects of Tau on Autophagy and Mitochondrial Homeostasis: Insights Into the Mechanisms of Neurodegeneration in FTLD-Tau"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"C9orf72 Controls the Balance of Th17 and T Regulatory Cell Fate Choice"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Direct Neuronal Reprogramming: A New Avenue for Studying Neurodegeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural Biology of FTD
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Structural Basis for Ribosome Inhibition in C9ORF72-FTD"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Molecular Visualization of TDP43 Architecture in situ "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Distinct Tau Filament Folds in Familial Frontotemporal Dementia Due to the MAPT S305I Mutation"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Small Tau Aggregates Exhibit Disease-Specific Molecular Profiles across Tauopathies"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contributions of Lipid Metabolism to FTD and Other Neurodegenerative Diseases
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Structure and Function of Neuronal Lipid Droplets"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"When Proteostasis Meets Lipid Metabolism in Neurodegeneration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Tau-Induced Synaptic Plasticity Dysregulation in Neurodegenerative Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Distinct Lysosomal Dysfunction Patterns of Progranulin Deficiency in the CNS Implicate Progranulin in Cell Type-Specific Protein Sorting"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Leveraging a Transferrin Receptor-Based Transport Vehicle for Protein Replacement Therapy in GRN-Associated Frontotemporal Dementia"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Pathological TDP-43 Filaments Accumulate at Synapses and Cause Synaptic Dysfunction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Mouse Models of TDP-43 Proteinopathies"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Targeting Multiproteinopathies: Perspectives from Pathology and Genetics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"TDP-43 (LATE) Driven Transcriptomic Changes in Animal Models and Human Poly-Proteinopathy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"TDP-43 Restricts Cryptic Transposable Element Splicing"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Vascular Dementia and the Blood Brain Barrier
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Neuro-Vascular Interactions in The Brain"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Linking Tau Pathology to Cerebral Microvascular Dysfunction Through Metabolic Reprogramming"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Linking Iron Accumulation to Endothelial Dysfunction in Progressive Supranuclear Palsy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Human Brain Vascular Genomics in Aging and Dementia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Vascular Brain Injury Alone Presents a Transcriptionally Diverging White Matter Microglia Cell State Distinct from Alzheimer’s Disease"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"PFO as a Potential Contributor to Vascular Cognitive Impairment through Homocysteine-Mediated White Matter Injury"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Vascular Transcriptomic Profiles of Primary Tauopathies Versus Alzheimer’s Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Clinical Translation and Therapeutics in FTD
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Identification of an Initiating Step for TDP-43 Proteinopathies and Development of a Therapeutic Strategy to Restore Nuclear TDP-43"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Clinical Stage Therapeutic Approaches to FTLD"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Dual-Targeting snRNA Gene Therapy Rescues STMN2 and UNC13A Splicing in TDP-43 Proteinopathies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Phase IB/2A Data: Sortilin Inhibition with VES001 in Human GRN Mutation Carriers Was Well-Tolerated and Elevated Plasma and CSF Progranulin"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure