Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Translating Genetic and Tissue Engineering Insights to Medicine
Discussion Leader: Elisabeth Binder (Max Planck Institute of Psychiatry, Germany)
7:40 pm - 8:20 pm
Arnold Kriegstein (UCSF, United States)
"Genomic Insights into Human Cortical Development Across the Lifespan"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Cecilia Cotta-Ramusino (Tessera Therapeutics, United States)
"Writing DNA with RNA: Opening an Era of Genome Engineering Based on Target Primed Reverse Transcription"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early Human Brain Development
Discussion Leader: Juergen Knoblich (Institute of Molecular Biotechnology (IMBA), Austria)
9:00 am - 9:20 am
Flora Vaccarino (Yale University, United States)
"Regional Specification and Patterning in Organoid Models of the Early Human Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pierre Vanderhaeghen (VIB KULeuven, Belgium)
"Mechanisms Linking Development and Evolution of Human Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Magdalena Zernicka-Goetz (University of Cambridge, United Kingdom)
"Building Embryo Models from Stem Cells to Understand Self-Organization"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Randolph Ashton (University of Wisconsin, United States) and Janina Jeff (Illumina, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functional Genomics of Neurodevelopmental Disorders
Discussion Leader: Flora Vaccarino (Yale University, United States)
7:30 pm - 7:50 pm
Michael Talkowski (MGH Broad Institute, United States)
"Functional Convergence Across Diverse Genes and Mutational Mechanisms in Neuropsychiatric Disorders"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Danielle Posthuma (Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, The Netherlands)
"From GWAS to Function - How to Leverage Results from GWAS to Gain Mechanistic Disease Insight"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Laura Huckins (Yale School of Medicine, United States)
"Integrating Gene-Environment Interactions in Psychiatric Disorder Risk"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Steve McCarroll (Harvard Medical School; Broad Institute, United States)
"Neurons and Astrocytes in Schizophrenia"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Technological Advances: Functional Genomics
Discussion Leaders: Rong Fan (Yale University, United States)
9:00 am - 9:20 am
Andrew Anzalone (Prime Medicine, United States)
"Prime Editing for Therapeutic Applications"
9:20 am - 9:30 am
Discussion
9:30 am - 10:10 am
Jonathan Gootenberg (MIT, United States) and Omar Abudayyeh (Massachusetts Institute of Technology, United States)
"Molecular Technologies for Genome Editing and Cell Control"
10:10 am - 10:30 am
Discussion
11:30 am - 12:00 pm
Coffee Break
12:00 pm - 12:20 pm
Michelle Chen (Genentech, United States)
"Single-cell Multiomics to Understand Mechanisms of Brain Aging and Neurodegeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 12:40 pm
Short Talk Selected from Poster Abstracts
12:30 pm - 1:30 pm
Lunch
12:40 pm - 12:45 pm
Discussion
12:45 pm - 12:55 pm
Short Talk Selected from Poster Abstracts
12:55 pm - 1:00 pm
Discussion
1:00 pm - 1:30 pm
Poster Previews
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stem Cells and Neuropsychiatric Disorders
Discussion Leader: Danielle Posthuma (Centre for Neurogenomics and Cognitive Research, VU University Amsterdam, The Netherlands)
7:30 pm - 7:50 pm
Thomas Sudhof (Stanford University, United States)
"Probing Neuropsychiatric Disease Mechanisms in Human Neurons: The NRXN1 Story"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Giorgia Quadrato (Keck School of Medicine, United States)
"Modeling Human Brain Development and Disease at Single-Cell Resolution with Brain Organoids"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sergiu Pasca (Stanford University, United States)
"From Stem Cells to Organoids to Assembloids and Toward Buildings Human Circuits in Living Systems to Study Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Technological Advances: Physiological Relevance
Discussion Leader: Fred Gage (The Salk Institute, United States)
9:00 am - 9:20 am
Guo-li Ming (University of Pennsylvania, United States)
"Human Brain-Region Specific Organoids for Understanding Human Brain Development and Disorders"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Mathew Blurton-Jones (The University of California, Irvine, United States)
"Using iPS-Microglia and Chimeric Mice to Study the Function of Alzheimer’s Disease Risk Genes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kristin Baldwin (Columbia University, United States)
"Insights into Neurodevelopment and Disease Using Interspecies Brain Chimeras"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Randolph Ashton (University of Wisconsin, United States)
"Quantitative High Throughput Screening of Human Neurodevelopmental Risk Using the RosetteArrayTM Platform"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stem Cells and Neurodegenerative Disorders
Discussion Leader: Sally Temple (Neural Stem Cell Institute, United States)
7:30 pm - 7:50 pm
Celeste Karch (Washington University School of Medicine, United States)
"Modeling Genetic Risk for Alzheimer's Disease with Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:00 pm
Hemali Phatnani (Columbia University/New York Genome Center, United States)
"Applying Spatial Genomics to Study the Central Nervous System in Health and Disease"
8:00 pm - 8:20 pm
Fred Gage (The Salk Institute, United States)
"Direct Reprogram of Neurons From Patient-Derived Fibroblasts Captures the Risks of Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Martin Kampmann (University of California, San Francisco, United States)
"CRISPR-Based Functional Genomics in iPSC Models of Brain Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Technological Advance: Improved Cellular Diversity and Aging In Vitro
Discussion Leader: Kristin Baldwin (Columbia University, United States)
9:00 am - 9:20 am
Andrew Yoo (Washington University School of Medicine, United States)
"Age-Dependent Modeling of Huntington's Disease Through Direct Neuronal Reprogramming"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jerome Mertens (University of Innsbruck, Austria)
"Neuronal Fate Loss and Metabolic Transformation in Age-Equivalent Alzheimer Patient Neurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Nan Yang (Icahn School of Medicine at Mount Sinai, United States)
"Shaping the Identity of Neurons from Human Stem Cells"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Sally Temple (Neural Stem Cell Institute, United States)
"Brain iPSC-Derived Organoids as a Tool to Model and Combat Tauopathy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technological Advance: CRISPR Screening
Discussion Leader: Martin Kampmann (University of California, San Francisco, United States)
7:30 pm - 7:50 pm
Xin Jin (Scripps Research, United States)
"Scalable Investigation of Gene Function In Vivo"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
John Doench (Broad Institute, United States)
"Expanding the Functional Genomics Toolbox with Cas12a"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Rong Fan (Yale University, United States)
"Spatial Functional Multi-Omics Sequencing"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure