Deciphering the Mechanisms and Functions of Chromatin Organization in Eukaryotic Genomes

The Genome Architecture in Cell Fate and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 3-dimensional organization of eukaryotic genomes within the nucleus has emerged as an important aspect of many cellular processes. Delineation of its regulation has led to insights into normal physiology and diseases. Technological advancements have allowed researchers to interrogate higher-order chromatin structures at unprecedented resolutions and in distinct biological contexts. We now understand that interplay between diverse pathways regulate the nuclear organization in different cell types. While great strides have been made in the past decade, the underlying molecular mechanism that controls genome architecture remains to be fully understood. The 2023 conference on Genome Architecture in Cell Fate and Disease: “Deciphering the mechanisms of chromatin organization in eukaryotic genomes” is the fourth meeting of this series that aims to promote discussion in the field of 3D genome organization. Specific focus will be placed on epigenetic mechanisms, regulation during development, chromatin dysfunction in disease, and technology development.